TY  - JOUR
TI  - The Effect of Maternal-Pup Separation on Maternal Systolic and Diastolic Blood Pressure in Spra-gue Dawley Rats
AB  - This study investigates changes in systolic and diastolic blood pressure in Sprague Dawley rat dams exposed to postpartum stress. Eighteen pregnant dams were randomly divided into three groups: Control (C, n = 6, no-stress), Maternal Separation (MS, n = 6), and Brief Maternal Separation (BMS, n = 6). The dams and pups in group C were housed under standard conditions in their cages at the animal facility during the postpartum period. From postpartum day 2 to day 14, the dams and pups in group MS and BMS were separated from each other every day for 3-h and 15-min, respectively. Systolic and diastolic blood pressures of the dams were recorded on postpartum days 2, 8, and 14 by tail-cuff method. The findings show that the 3-h dam-pup separation caused high systolic blood pressure in dams, compared to the control dams at all time points that blood pressure was recorded (p<0.001). However, this effect is significant only on postpartum days 2 (p<0.01) and 8 (p<0.001) when compared to the dams that were subjected to 15-min separation. In addition, the 3-h and 15-min dam-pup separations lead to high diastolic blood pressure when compared to the controls throughout the experiment. The 3-h separation caused high diastolic blood pressure only on day 2, when compared to the dams that were subjected to the 15-min pup separation (p<0.01). The obtained data indicate that postpartum dam-pup separation may lead to an increase in blood pressure in Sprague-Dawley rats.
AU  - EKICI, MEHMET
DO  - 10.47027/duvetfd.839345
PY  - 2021
JO  - Dicle Üniversitesi Veteriner Fakültesi Dergisi
VL  - 14
IS  - 1
SN  - 1307-9972
SP  - 31
EP  - 34
DB  - TRDizin
UR  - http://search/yayin/detay/493721
ER  -