Abstract In this descriptive study, we aimed to present lipoma cases diagnosed in the gastrointestinal tract and to evaluate the clinicopathological features of these tumors based on literature review. In this study, patient files of 19 cases diagnosed with lipoma of the gastrointestinal tract between 2006 and 2018 were retrospectively reviewed from the archives of the Department of Pathology of Faculty of Medicine. Seventeen cases with lipoma of the gastrointestinal tract were diagnosed between 2006 and 2018. Eleven of the cases were female (%57,9), and eight (42,1%) were male. The mean age of the patients was 62,3 years (range: 36-78 years). Of the 17 cases, 14 were located in the colon, 3 in the small intestine and 1 in the stomach. The classical morphology of lipoma was seen in all cases except one case that was diagnosed with angiolipoma located in the descending colon. Generally, incidentally detected lipomas, which can be accompanied by adenocarcinomas, are tumors that can lead to gastrointestinal symptoms such as obstruction, intussusception and bleeding, and differential diagnosis of malignancies is required. All cases should be examined by appropriate radiological and endoscopic methods before operation and the most appropriate treatment option should be evaluated for each case.