Effects of epirubicin and daunorubicin on cell proliferation and cell death in HeLa cells

ARICAN, Özcan Gül; SOY, Nazlı Nazmiye

Effects of epirubicin and daunorubicin on cell proliferation and cell death in HeLa cells

Özcan Gül ARICAN, (İstanbul Üniversitesi, Fen Fakültesi, Biyoloji Bölümü, İstanbul, Türkiye)

Nazlı Nazmiye SOY (İstanbul Üniversitesi, Fen Fakültesi, Biyoloji Bölümü, İstanbul, Türkiye)

Journal of Cell and Molecular Biology

2 0

Yıl: 2005 Cilt: 4 Sayı: 1 Sayfa Aralığı: 47 - 52 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Effects of epirubicin and daunorubicin on cell proliferation and cell death in HeLa cells

Öz:

Antrasiklin türevi epirubisin ve daunorubjsin, özellikle yaygın tümörlerde sıklıkla kullanılan antibiyotiklerdir. Bu çalışmada, epirubisin, daunorabisin ve epirubisin+daunorubisinin in vitro dozları insan serviks kanseri kökenli HeLa hücre soyuna uygulanarak, hücre çoğalması ve hücre ölümü üzerine olan etkileri MTT yöntemi ile araştırıldı. Deneylerden elde edilen sonuçlara göre, ilaç uygulama süresine bağlı olarak daunorubisinin epirubisinden daha sitotoksik bir etkiye sahip olduğu belirlendi. Tüm deney grupları içerisinde en etkili sonuç, epirubisin+daunorubisin kombinasyonunda elde edildi (p< 0.001).

Anahtar Kelime: ilaç kombinasyonları daunorubisin hücre çoğalması HeLa hücreleri antibiyotikler kemoterapi programlanmış hücre ölümü epirubisin antineoplastik ajanlar

Konular: Biyokimya ve Moleküler Biyoloji

Epirubisin ve daunorubisinin hücre çoğalması ve hücre ölümü üzerine etkilerinin HeLa hücrelerinde araştırılması

Öz:

Epirubicin and daunorubicin, antibiotics which are derivative of anthracyclines, are especially used on widespread tumors. In this study, effects on cell growth and cell death were examined by MTT method applying in vitro doses of epirubicin, daunorubicin and epirubicin+daunorubicin to human servical carcinoma derived HeLa cell line. According to the results obtained from the experiments it was determined that daunorubicin has more cytotoxic effect than epirubicin depending on the periods of drug exposure. In whole experiment groups, the most effective result was detected in epirubicin+daunorubicin combination (p< 0.001).

Anahtar Kelime: antibiotics chemotherapy apoptosis epirubicin antineoplastic agents drug combinations daunorubicin cell proliferation HeLa cells

Konular: Biyokimya ve Moleküler Biyoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ARICAN Ö, SOY N (2005). Effects of epirubicin and daunorubicin on cell proliferation and cell death in HeLa cells. , 47 - 52.
Chicago	ARICAN Özcan Gül,SOY Nazlı Nazmiye Effects of epirubicin and daunorubicin on cell proliferation and cell death in HeLa cells. (2005): 47 - 52.
MLA	ARICAN Özcan Gül,SOY Nazlı Nazmiye Effects of epirubicin and daunorubicin on cell proliferation and cell death in HeLa cells. , 2005, ss.47 - 52.
AMA	ARICAN Ö,SOY N Effects of epirubicin and daunorubicin on cell proliferation and cell death in HeLa cells. . 2005; 47 - 52.
Vancouver	ARICAN Ö,SOY N Effects of epirubicin and daunorubicin on cell proliferation and cell death in HeLa cells. . 2005; 47 - 52.
IEEE	ARICAN Ö,SOY N "Effects of epirubicin and daunorubicin on cell proliferation and cell death in HeLa cells." , ss.47 - 52, 2005.
ISNAD	ARICAN, Özcan Gül - SOY, Nazlı Nazmiye. "Effects of epirubicin and daunorubicin on cell proliferation and cell death in HeLa cells". (2005), 47-52.

APA	ARICAN Ö, SOY N (2005). Effects of epirubicin and daunorubicin on cell proliferation and cell death in HeLa cells. Journal of Cell and Molecular Biology, 4(1), 47 - 52.
Chicago	ARICAN Özcan Gül,SOY Nazlı Nazmiye Effects of epirubicin and daunorubicin on cell proliferation and cell death in HeLa cells. Journal of Cell and Molecular Biology 4, no.1 (2005): 47 - 52.
MLA	ARICAN Özcan Gül,SOY Nazlı Nazmiye Effects of epirubicin and daunorubicin on cell proliferation and cell death in HeLa cells. Journal of Cell and Molecular Biology, vol.4, no.1, 2005, ss.47 - 52.
AMA	ARICAN Ö,SOY N Effects of epirubicin and daunorubicin on cell proliferation and cell death in HeLa cells. Journal of Cell and Molecular Biology. 2005; 4(1): 47 - 52.
Vancouver	ARICAN Ö,SOY N Effects of epirubicin and daunorubicin on cell proliferation and cell death in HeLa cells. Journal of Cell and Molecular Biology. 2005; 4(1): 47 - 52.
IEEE	ARICAN Ö,SOY N "Effects of epirubicin and daunorubicin on cell proliferation and cell death in HeLa cells." Journal of Cell and Molecular Biology, 4, ss.47 - 52, 2005.
ISNAD	ARICAN, Özcan Gül - SOY, Nazlı Nazmiye. "Effects of epirubicin and daunorubicin on cell proliferation and cell death in HeLa cells". Journal of Cell and Molecular Biology 4/1 (2005), 47-52.