Objective: Intoxications are among preventable causes of morbidity and mortality among childhood and adolescent emergency diseases. In this study, we aimed to retrospectively investigate the demographic and clinical data of adolescent patients followed up in the intensive care unit for acute drug intoxication. Material and Method: In this retrospective study, demographic characteristics of adolescent patients treated with acute drug intoxication in Malatya Training and Research Hospital Intensive Care Unit (ICU); presence of pre-existing psychiatric illness; length of stay in the intensive care unit; received toxic substance; the reason for ingestion of toxic substances; if the type of toxic substance was a drug; form of the drug (tablets, suspensions); single drug or multiple drug; month of poisoning and their comorbidities were recorded. Results: A total of 60 patients (36 girls (60%) and 24 boys (40%)) were included in the study. The mean age of the patients was 16,6 years. 52 (86,6%) of the intoxications were caused by suicide, 3 (5%) by accident and 5 (8,3) by drug overdose. Drug intoxication was detected in 91,6% of the patients. Antidepressant (25%), analgesic (18,3%), antiepileptic (5%), narcotic (5%), antipsychotic (6,6%), antigribal (5%), antibiotic (5%) uptake were determined. 65% of patients had multiple drug intake and 35% had single drug intake. 26 patients (41,6%) were accompanied by at least one psychiatric disease and 4 patients with systemic disease (asthma, hypothyroidism, psoriasis). The mean duration of ICU stay was 2,3 days, and it was determined that intoxications occurred most frequently in winter (35%). One patient received mechanical ventilation support for two days and one patient underwent hemodiafiltration. In our study, no mortality was seen in any patient. Conclusion: In our study, it was found that most of the patients were girls, antidepressants and analgesics were the most common drugs in intoxication and history of psychiatric disorders were found significantly.