Do midkine levels in serum and follicular fluid affect IVFICSI outcome?

Ayşe Zehra ÖZDEMİR, (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Tüp Bebek Merkezi, Samsun, Türkiye)
Pervin Karlı, (Amasya Üniversitesi Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Amasya, Türkiye)
Bahattin Avcı (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Samsun, Türkiye)
Journal of health sciences and medicine (Online)
1 0
Yıl: 2020 Cilt: 3 Sayı: 3 Sayfa Aralığı: 301 - 306 Metin Dili: İngilizce DOI: 10.32322/jhsm.735162 İndeks Tarihi: 27-04-2022

Do midkine levels in serum and follicular fluid affect IVFICSI outcome?

Öz:
Objective: Current studies have demonstrated that midkine (MK) inhibits the apoptosis in granulosa cells and is responsible for follicular angiogenesis. The aim of this study was to investigate the relation of MK levels and ART outcome. Material and Method: The study included a total of 99 patients who underwent IVF-ICSI at Ondokuz Mayis University between February 2019 and April 2019. Of 99 patients, no embryo development was formed in 1 patient, no oocytes were obtained by oocyte pick up (OPU) in 14 patients and the oocyte cryopreservation was established in 17 patients. In total, 67 patients underwent fresh embryo transfer after IVF-ICSI. On the day of OPU, the level of midkine in serum and follicular fluids were examined. The primary outcome was determined as pregnancy and secondary outcome was determined as blastocyst‐ stage embryos. Results: The level of midkine in serum and follicular fluid was found to be higher in pregnant women compared with non-pregnant women (p=0.042 and p=0.01 respectively). Midkine levels in follicular fluid and serum lead to an increase in blastocyst development. Conclusion: Midkine levels in follicular fluid and serum may lead to an increase in blastocyst development. The level of midkine is higher in pregnant subjects than in non-pregnant subjects.
Anahtar Kelime:

Serum ve foliküler sıvıdaki midkin düzeyleri IVF-ICSI sonuçlarını etkiler mi?

Öz:
Amaç: Güncel çalışmalar, midkinin (MK) granüloza hücrelerinde apoptozu inhibe ettiğini ve foliküler anjiyogenezden sorumlu olduğunu göstermiştir. Bu çalışmanın amacı, midkin seviyeleri ile ART sonuçları arasındaki ilişkiyi araştırmaktır. Gereç ve Yöntem: Çalışmaya Şubat 2019 ve Nisan 2019 tarihleri arasında Ondokuz Mayıs Üniversitesi’nde IVF-ICSI uygulanan toplam 99 hasta dahil edildi. Çalışmadaki 99 hastanın birinde embriyo gelişimi sağlanamadı ve 14 hastada oosit toplanmasıyla (OPU) oosit elde edilmedi. ve oosit kriyoprezervasyon 17 hastada oluşturuldu. Toplam 67 hastaya IVF-ICSI sonrası taze embriyo transferi yapıldı. OPU gününde serum ve foliküler sıvılardaki midkin seviyesi incelendi. Primer sonuç gebelik, sekonder sonuç blastosist-aşamalı embriyolar olarak belirlendi. Bulgular: Serum ve foliküler sıvıdaki midkin düzeyi gebelerde gebe olmayanlara göre daha yüksek bulundu (p=0,042, p=0,01). Foliküler sıvı ve serumdaki midkin seviyeleri blastokist gelişiminde artışa neden olduğu görülmüştür. Sonuç: Foliküler sıvı ve serumdaki midkin seviyeleri blastokist gelişiminde artışa neden olabilir. Midkin seviyesi gebelerde gebe olmayanlara göre daha yüksek bulunmuştur.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA ozdemir a, Karlı P, AVCI B (2020). Do midkine levels in serum and follicular fluid affect IVFICSI outcome?. , 301 - 306. 10.32322/jhsm.735162
Chicago ozdemir ayse zehra,Karlı Pervin,AVCI BAHATTIN Do midkine levels in serum and follicular fluid affect IVFICSI outcome?. (2020): 301 - 306. 10.32322/jhsm.735162
MLA ozdemir ayse zehra,Karlı Pervin,AVCI BAHATTIN Do midkine levels in serum and follicular fluid affect IVFICSI outcome?. , 2020, ss.301 - 306. 10.32322/jhsm.735162
AMA ozdemir a,Karlı P,AVCI B Do midkine levels in serum and follicular fluid affect IVFICSI outcome?. . 2020; 301 - 306. 10.32322/jhsm.735162
Vancouver ozdemir a,Karlı P,AVCI B Do midkine levels in serum and follicular fluid affect IVFICSI outcome?. . 2020; 301 - 306. 10.32322/jhsm.735162
IEEE ozdemir a,Karlı P,AVCI B "Do midkine levels in serum and follicular fluid affect IVFICSI outcome?." , ss.301 - 306, 2020. 10.32322/jhsm.735162
ISNAD ozdemir, ayse zehra vd. "Do midkine levels in serum and follicular fluid affect IVFICSI outcome?". (2020), 301-306. https://doi.org/10.32322/jhsm.735162
APA ozdemir a, Karlı P, AVCI B (2020). Do midkine levels in serum and follicular fluid affect IVFICSI outcome?. Journal of health sciences and medicine (Online), 3(3), 301 - 306. 10.32322/jhsm.735162
Chicago ozdemir ayse zehra,Karlı Pervin,AVCI BAHATTIN Do midkine levels in serum and follicular fluid affect IVFICSI outcome?. Journal of health sciences and medicine (Online) 3, no.3 (2020): 301 - 306. 10.32322/jhsm.735162
MLA ozdemir ayse zehra,Karlı Pervin,AVCI BAHATTIN Do midkine levels in serum and follicular fluid affect IVFICSI outcome?. Journal of health sciences and medicine (Online), vol.3, no.3, 2020, ss.301 - 306. 10.32322/jhsm.735162
AMA ozdemir a,Karlı P,AVCI B Do midkine levels in serum and follicular fluid affect IVFICSI outcome?. Journal of health sciences and medicine (Online). 2020; 3(3): 301 - 306. 10.32322/jhsm.735162
Vancouver ozdemir a,Karlı P,AVCI B Do midkine levels in serum and follicular fluid affect IVFICSI outcome?. Journal of health sciences and medicine (Online). 2020; 3(3): 301 - 306. 10.32322/jhsm.735162
IEEE ozdemir a,Karlı P,AVCI B "Do midkine levels in serum and follicular fluid affect IVFICSI outcome?." Journal of health sciences and medicine (Online), 3, ss.301 - 306, 2020. 10.32322/jhsm.735162
ISNAD ozdemir, ayse zehra vd. "Do midkine levels in serum and follicular fluid affect IVFICSI outcome?". Journal of health sciences and medicine (Online) 3/3 (2020), 301-306. https://doi.org/10.32322/jhsm.735162
Sayfa Oluşturulma Tarihi
23-04-2024 22:1

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