TY  - JOUR
TI  - PROPIONYLCARNITINE AND FREE CARNITINE ARE NEW BIOMARKERS IN THE FOLLOW-UP PERIOD OF MUCOPOLYSACCARIDOSIS TO SCREEN OXIDATIVE STRESS
AB  - Objective There is no applicable and easy procedure to screen oxidative stress in mucopolysaccaridosis (MPS) patients. The aim herein was to show the antioxidative properties of free carnitine (FC) and propionylcarnitine (PC) with respect to oxidative markers in MPS and use a simple and easy method in patient follow-up. Material and Methods FC and PC were studied as an antioxidative marker using tandem mass spectroscopy and malondialdehyde (MDA) was studied as an oxidative marker in 27 MPS patients and 24 healthy volunteers. Results While the PC and FC levels were significantly decreased, the MDA levels were higher in the MPS patients than in the healthy volunteers.When compared between the enzyme-treated MPS patients and untreated MPS patients, there were no significant differences between the groups. MDA was found to inversely correlated with PC (r =–0.402, P=0.003).It was noteworthy that PC had a significant correlation with MDA. Conclusion The findings revealed that the affected patients had higher MDA levels and lower PC and FC levels, indicating an imbalance through the oxidative side. An applicable method of FC and PC measurement could be used to screen patients, considering them as new antioxidative markers in the patient follow-up period for the response of enzyme replacement therapy and/ or antioxidant drugs.
AU  - Inci, Aslı
AU  - Tumer, Leyla
AU  - Olgac, Asburce
AU  - Ezgu, Fatih Suheyl
AU  - Genç Derin, Betül
AU  - Biberoglu, Gursel
AU  - OKUR, ILYAS
DO  - 10.17343/sdutfd.928607
PY  - 2021
JO  - Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi
VL  - 28
IS  - 4
SN  - 1300-7416
SP  - 565
EP  - 571
DB  - TRDizin
UR  - http://search/yayin/detay/502538
ER  -