Yıl: 2020 Cilt: 5 Sayı: 3 Sayfa Aralığı: 125 - 130 Metin Dili: İngilizce DOI: 10.26663/cts.2020.00025 İndeks Tarihi: 13-05-2022

The relationship of platelet lymphocyte ratio with prognosis in patients with chronic obstructive pulmonary disease

Öz:
Background: The aim of this study is to analyze prognostic biomarkers, and determine the biomarkers which are more sensitive in the patients that were presented with acute chronic obstructive pulmonary disease (COPD) exacerbation to the emergency department. Materials and Methods: The data of 243 patients presented with acute COPD exacerbation and 122 COPD patients with stable status as control group were analyzed retrospectively. The patients, whose arterial blood gas (ABG) studied, with Acute COPD exacerbation were identified as Group I. The patients whose venous blood gas (VBG) studied were identified as Group II and stable COPD patients whose ABG studied were identified as Control Group. The prognostic biomarker values were compared in the patients of Group I, Group II and Control Group Results: The mean age of the patients was 68.61 ± 11.02 and the mean age of the control group was 68.25 ± 11.07. It was found that platelet lymphocyte ratio (PLR) values were very high in both Group I and Group II compared to the control Group (P < 0.001). There was a significant difference related with mean erythrocyte distribution width (RDW) in Group I, mean erythrocyte volume (MCV)’ in group II, MPV and platelet count (PLT) in both Group I and Group II (P < 0.001). Conclusions: Especially in acute COPD exacerbation, PLR may be a useful inflammatory biomarker to reflect the severity and activity of inflammation in COPD patients.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Steiropoulos P, Papanas N, Nena E, Xanthoudaki M, Goula T, Froudarakis M et al. Mean platelet volume and platelet distribution width in patients with chronic obstructive pulmonary disease: the role of comorbidities. Angiology 2013;64:535-9.
  • 2. Van den Berg ME, Stricker BH, Brusselle GG, Lahousse L. Chronic obstructive pulmonary disease and sudden cardiac death: A systematic review. Trends Cardiovasc Med 2016;26:606-13.
  • 3. Malerba M, Radaeli A, Nardin M, Clini E, Carpagnano GE, Sciatti E et al. Endothelial dysfunction assessment by noninvasive peripheral arterial tonometry in patients with chronic obstructive pulmonary disease compared with healthy subjects. Clin Respir J 2018;12:1466-72.
  • 4. Decramer M, Janssens W, Miravitlles M. Chronic obstructive pulmonary disease. Lancet 2012;379:1341-51.
  • 5. Singh S, Verma SK, Kumar S, Ahmad MK, Nischal A, Singh SK et al. Correlation of severity of chronic obstructive pulmonary disease with potential biomarkers. Immunol Lett 2018;196:1-10.
  • 6. Barnes P. J. Inflammatory mechanisms in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol 2016;138:16-27.
  • 7. Günay E, Ulaşlı S.S, Akar O, Ahsen A, Günay S, Koyuncu T et al. Neutrophil-to-Lymphocyte Ratio in Chronic Obstructive Pulmonary Disease: A Retrospective Study. Inflammation 2014; 37:374-80.
  • 8. Wang M, Zhang J, Ji Q, Yang Q, Zhao F, Li W et al. Evaluation of platelet distribution width in chronic obstructive pulmonary disease patients with pulmonary embolism. Biomark Med 2016;10:587-96.
  • 9. Kıvanc T, Kulaksızoglu S, Lakadamyalı H, Eyuboglu F. Importance of laboratory parameters in patients with obstructive sleep apnea and their relationship with cardiovascular diseases. J Clin Lab Anal 2018;32:1-6.
  • 10. Kalemci S, Akin F, Sarihan A, Sahin C, Zeybek A, Yilmaz N. The relationship between hematological parameters and the severity level of chronic obstructive lung disease. Pol Arch Intern Med 2018;128:171-7.
  • 11. Villa E, Patrucco F, Malerba M. Potential role of hematological parameters in patients with chronic obstructive pulmonary disease: current point of view. Pol Arch Intern Med 2018;128:143-4.
  • 12. Kurtipek E, Bekci TT, Kesli R, Sami SS, Terzi Y. The role of neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in exacerbation of chronic obstructive pulmonary disease. J Pak Med Assoc 2015;65:1283-7.
  • 13. Kumar P, Law S, Sriram KB. Evaluation of platelet lymphocyte ratio and 90-day mortality in patients with acute exacerbation of chronic obstructive pulmonarydisease. J Thorac Dis 2017;9:1509-16.
  • 14. Tertemiz KC, Ozgen Alpaydin A, Sevinc C, Ellidokuz H, Acara AC, Cimrin A. Could “red cell distribution width” predict COPD severity? Rev Port Pneumol 2016;22:196-201.
  • 15. Seyhan EC, Özgül MA, Tutar N, Ömür I, Uysal A, Altin S. Red blood cell distribution and survival in patients with chronic obstructive pulmonary disease. COPD 2013;10:416-24.
  • 16. Ozgul G, Seyhan EC, Özgül MA, Günlüoğlu MZ. Red Blood Cell Distribution Width in Patients With Chronic Obstructive Pulmonary Disease and Healthy Subjects. Arch Bronconeumol 2017;53:107-13.
  • 17. Ulasli SS, Ozyurek BA, Yilmaz EB, Ulubay G. Mean platelet volume as an inflammatory marker in acute exacerbation of chronic obstructive pulmonary disease. Pol Arch Med Wewn 2012;122:284-90.
  • 18. Makhlouf HA, Sadek SH, Nafady AAH. Platelet function in diabetic and nondiabetic patients with chronic obstructive pulmonary disease: a case control study. Clin Respir J 2018;12:48-56.
  • 19. Karadeniz G, Aktoğu S, Erer OF, Kır SB, Doruk S, Demir M et al. Predictive value of platelet-to-lymphocyte ratio in exacerbation of chronic obstructive pulmonary disease. Biomark Med 2016;10:701-10.
  • 20. Harrison MT, Short P, Williamson PA, Singanayagam A, Chalmers JD, Schembri S. Thrombocytosis is associated with increased short and long term mortality after exacerbation of chronic obstructive pulmonary disease: a role for antiplatelet therapy? Thorax 2014;69:609-15.
  • 21. Chen G, Wu C, Luo Z, Teng Y, Mao S. Platelet-lymphocyte ratios: a potential marker for pulmonary tuberculosis diagnosis in COPD patients. Int J Chron Obstruct Pulmon Dis 2016;11:2737-40.
APA ÖNCÜ M, cobanoglu u (2020). The relationship of platelet lymphocyte ratio with prognosis in patients with chronic obstructive pulmonary disease. , 125 - 130. 10.26663/cts.2020.00025
Chicago ÖNCÜ MEHMET REŞİT,cobanoglu ufuk The relationship of platelet lymphocyte ratio with prognosis in patients with chronic obstructive pulmonary disease. (2020): 125 - 130. 10.26663/cts.2020.00025
MLA ÖNCÜ MEHMET REŞİT,cobanoglu ufuk The relationship of platelet lymphocyte ratio with prognosis in patients with chronic obstructive pulmonary disease. , 2020, ss.125 - 130. 10.26663/cts.2020.00025
AMA ÖNCÜ M,cobanoglu u The relationship of platelet lymphocyte ratio with prognosis in patients with chronic obstructive pulmonary disease. . 2020; 125 - 130. 10.26663/cts.2020.00025
Vancouver ÖNCÜ M,cobanoglu u The relationship of platelet lymphocyte ratio with prognosis in patients with chronic obstructive pulmonary disease. . 2020; 125 - 130. 10.26663/cts.2020.00025
IEEE ÖNCÜ M,cobanoglu u "The relationship of platelet lymphocyte ratio with prognosis in patients with chronic obstructive pulmonary disease." , ss.125 - 130, 2020. 10.26663/cts.2020.00025
ISNAD ÖNCÜ, MEHMET REŞİT - cobanoglu, ufuk. "The relationship of platelet lymphocyte ratio with prognosis in patients with chronic obstructive pulmonary disease". (2020), 125-130. https://doi.org/10.26663/cts.2020.00025
APA ÖNCÜ M, cobanoglu u (2020). The relationship of platelet lymphocyte ratio with prognosis in patients with chronic obstructive pulmonary disease. Current Thoracic Surgery, 5(3), 125 - 130. 10.26663/cts.2020.00025
Chicago ÖNCÜ MEHMET REŞİT,cobanoglu ufuk The relationship of platelet lymphocyte ratio with prognosis in patients with chronic obstructive pulmonary disease. Current Thoracic Surgery 5, no.3 (2020): 125 - 130. 10.26663/cts.2020.00025
MLA ÖNCÜ MEHMET REŞİT,cobanoglu ufuk The relationship of platelet lymphocyte ratio with prognosis in patients with chronic obstructive pulmonary disease. Current Thoracic Surgery, vol.5, no.3, 2020, ss.125 - 130. 10.26663/cts.2020.00025
AMA ÖNCÜ M,cobanoglu u The relationship of platelet lymphocyte ratio with prognosis in patients with chronic obstructive pulmonary disease. Current Thoracic Surgery. 2020; 5(3): 125 - 130. 10.26663/cts.2020.00025
Vancouver ÖNCÜ M,cobanoglu u The relationship of platelet lymphocyte ratio with prognosis in patients with chronic obstructive pulmonary disease. Current Thoracic Surgery. 2020; 5(3): 125 - 130. 10.26663/cts.2020.00025
IEEE ÖNCÜ M,cobanoglu u "The relationship of platelet lymphocyte ratio with prognosis in patients with chronic obstructive pulmonary disease." Current Thoracic Surgery, 5, ss.125 - 130, 2020. 10.26663/cts.2020.00025
ISNAD ÖNCÜ, MEHMET REŞİT - cobanoglu, ufuk. "The relationship of platelet lymphocyte ratio with prognosis in patients with chronic obstructive pulmonary disease". Current Thoracic Surgery 5/3 (2020), 125-130. https://doi.org/10.26663/cts.2020.00025