Yıl: 2022 Cilt: 8 Sayı: 1 Sayfa Aralığı: 9 - 15 Metin Dili: İngilizce DOI: 10.18621/eurj.869966 İndeks Tarihi: 29-07-2022

The paraoxonase 1 activity and lipid levels in umbilical cord blood and maternal venous blood, and their relations according to birth weight

Öz:
Objectives: Aim of this study is to find out the clinical relevance of estimating paraoxonase activity of PON1 enzyme, triglyceride (TG), total cholesterol, HDL, and LDL levels in maternal serum and umbilical cord blood according to birth weight. Methods: Venous blood samples were taken from mothers just before birth. Babies were divided into four groups: normal-weight babies, premature babies, low birth weight babies, and postmature babies. The weight of the newborns was measured and cord blood was taken. The samples were looked at HDL, LDL, total cholesterol, triglyceride levels and PON1 activities. We have investigated the paraoxonase activity of the PON1 enzyme. Enzyme activity assay was obtained spectrophotometrically measurement of p‐nitrophenol at 412 nm. Results: Maternal PON1 paraoxonase activity levels in Pre-Term show a significant decrease in cases as compared to other groups. Baby PON1 paraoxonase activity levels are also found to be significantly decreased in cases concerning the Term and Post-Term groups. There was a significant difference in all values the such as baby's weight, TG, Total cholesterol, HDL, LDL and PON1.belonging to babies (p < 0.05).Conclusions: Decreased paraoxonase activity in maternal serum may be considered as an additional risk factor for the development of low birth weight. It appears that PON1 activity plays an important role in infant development and affects birth weight. We think that the paraoxonase activity of the PON1 enzyme in mothers may be a marker in predicting the babies who are at risk in terms of birth weight.
Anahtar Kelime: Birth weight Baby cord blood Maternal serum Paraoxonase1 enzyme lipid levels

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
0
0
0
  • 1. Sharma D, Sharma P, Shastri S. Genetic, metabolic and endocrine aspect of intrauterine growth restriction: an update. J Matern Fetal Neonatal Med 2017;30:2263-75.
  • 2. Gupta S, Agarwal A, Banerjee J, Alvarez JG. The role of oxidative stress in spontaneous abortion and recurrent pregnancy loss: a systematic review. Obstet Gynecol Surv 2007;62:335-47.
  • 3. Negi R, Pande D, Kumar A, Khanna RS, Khanna HD. In vivo oxidative DNA damage and lipid peroxidation as a biomarker of oxidative stress in preterm low-birthweight infants. J Trop Pediatr 2012;58:326-8.
  • 4. World Health Organization. International statistical classification of diseases and related health problems. Tenth revision. Geneva: World Health Organization; 1992.
  • 5. Halliwell B, Gutteridge JMC. Lipid peroxidation oxygen radicals. cell damage and antioxidant therapy. Lancet 1984;23:1396- 97.
  • 6. Islam MdO, Bacchetti T, Ferretti G. Alterations of antioxidant enzymes and biomarkers of nitro-oxidative stress in tissues of bladder cancer. Oxid Med Cell Longev 2019;2019:2730896.
  • 7. Hegele RA. Paraoxonase genes and disease. Ann Med 1999;31:217-24.
  • 8. Mackness MI, Halton SD, Pend T, Warner S, Walken CN. The seperation of sheep and human serum A-esterase activity with the lipoprotein fraction by ultracentrifugation. Biochem Physiol 1985;82:675-77.
  • 9. Rodrigo L, Hernández AF, López-Caballero JJ, Gil F, Pla A. Immunohistochemical evidence for the expression and induction of paraoxonase in rat liver. kidney. lung and brain tissue. Implications for its physiological role. Chem Biol Interact 2001;137:123-37.
  • 10. Yilmaz A, Dilek E. Antibiotics used in patients after surgery and effects of human serum paraoxonase-I (PON1) enzyme activity. Protein Pept Lett 2019;26:215-20.
  • 11. Yildiz A, Sezen Y, Gur M, Yilmaz R, Demirbag R, Erel O. Association of paraoxonase activity and coronary collateral flow. Coron Artery Dis 2008;19:441-7.
  • 12. Renault F, Chabrière E, Andrieu JP, Dublet B, Masson P, Rochu DJ. Tandem purification of two HDL-associated partner proteins in human plasma. paraoxonase (PON1) and phosphate binding protein (HPBP) using hydroxyapatite chromatography. J Chromatogr B 2006;836:15-21.
  • 13. Mackness B, Durrington PN, Mackness M. Human serum paraoxonase. Gen Pharmac 1998;31:329-36.
  • 14. Ferretti G, Cester AM, Bacchetti T, Raffaelli F, Vignini A, Orici F, et al. Leptin and paraoxonase activity in cord blood from obese mothers. J Matern Fetal Neonatal Med 2014;27:1353-6.
  • 15. Chen D, Hu Y, Chen C, Yang F, Fang Z, Wang L, et al. Polymorphisms of the paraoxonase gene and risk of preterm delivery. Epidemiology 2004;15:466-70.
  • 16. Rotshenker-Olshinka K, Michaeli J, Srebnik N, Terlezky S, Schreiber L, Farkash R, et al. Recurrent intrauterine growth restriction: characteristic placental histopathological features and association with prenatal vascular Doppler. Arch Gynecol Obstet 2019;300:1583-9.
  • 17. Dilek E, Çağlar S, Cardak S, Karakoc B, Çağlar B, Şahin O. Synthesis, characterization, and in vitro effect of the Cu (II) complex with niflumic acid and 3-picoline on paraoxanase-I. Archiv Der Pharmazie 2019;352:e1900007.
  • 18. Ouidir M, Mendola P, Workalemahu T, Grewal J, Grantz KL, Zhang C, et al. Race-ethnic differences in the associations of maternal lipid trait genetic risk scores with longitudinal fetal growth. J Clin Lipidol 2019;13:821-31.
  • 19. Brittos T, de Souza WB, Anschau F, Pellanda L. Lipids and leukocytes in newborn umbilical vein blood. birth weight and maternal body mass index. J Dev Orig Health Dis 2016;7:672-7.
  • 20. Kim YJ, Hong YC, Lee KH, Park HJ, Park EA, Moon HS, et al. Oxidative stress in pregnant women and birth weight reduction. Reprod Toxicol 2005;19:487-92.
  • 21. Negi R, Pande D, Kumar A, Khanna RS, Khanna HD. Evaluation of biomarkers of oxidative stress and antioxidant capacity in the cord blood of preterm low birth weight neonates. J Matern Fetal Neonatal Med 2012;25:1338-41.
  • 22. Senti M, Tomas M, Fito M. Antioxidant paraoxonase 1 activity in the metabolic syndrome. J Clin Endocrinol Metab 2003;88:5422-6.
  • 23. Mogarekar MR, Dhabe MG, Gujrathi CC. The Paraoxonase 1 arylesterase activity. Total oxidative stress. Nitric oxide and vitamin C levels in maternal serum, and their relation to birth weight of newborn. J Obstet Gynaecol India 2016;66:327-32.
  • 24. Lawlor DA, Gaunt TR, Hinks LJ, Smith GD, Timpson N, Day INM, et al. The association of the PON-1 Q192R polymorphism with complications and outcomes of pregnancy: findings from the British Women’s Heart and Health cohort study. Paediatr Perinat Epidemiol 2006;20:244-50.
  • 25. Kumru S, Aydin S, Gursu MF, Ozcan Z. Changes of serum paraoxonase (an HDL-cholesterol-associated lipophilic antioxidant) and arylesterase activities in severe preeclamptic women. Eur J Obstet Gynecol Reprod Biol 2004;114:177-81.
APA Kadıoğlu B, Nalçakan A, Dilek E (2022). The paraoxonase 1 activity and lipid levels in umbilical cord blood and maternal venous blood, and their relations according to birth weight. , 9 - 15. 10.18621/eurj.869966
Chicago Kadıoğlu Berrin Göktuğ,Nalçakan Aysel,Dilek Esra The paraoxonase 1 activity and lipid levels in umbilical cord blood and maternal venous blood, and their relations according to birth weight. (2022): 9 - 15. 10.18621/eurj.869966
MLA Kadıoğlu Berrin Göktuğ,Nalçakan Aysel,Dilek Esra The paraoxonase 1 activity and lipid levels in umbilical cord blood and maternal venous blood, and their relations according to birth weight. , 2022, ss.9 - 15. 10.18621/eurj.869966
AMA Kadıoğlu B,Nalçakan A,Dilek E The paraoxonase 1 activity and lipid levels in umbilical cord blood and maternal venous blood, and their relations according to birth weight. . 2022; 9 - 15. 10.18621/eurj.869966
Vancouver Kadıoğlu B,Nalçakan A,Dilek E The paraoxonase 1 activity and lipid levels in umbilical cord blood and maternal venous blood, and their relations according to birth weight. . 2022; 9 - 15. 10.18621/eurj.869966
IEEE Kadıoğlu B,Nalçakan A,Dilek E "The paraoxonase 1 activity and lipid levels in umbilical cord blood and maternal venous blood, and their relations according to birth weight." , ss.9 - 15, 2022. 10.18621/eurj.869966
ISNAD Kadıoğlu, Berrin Göktuğ vd. "The paraoxonase 1 activity and lipid levels in umbilical cord blood and maternal venous blood, and their relations according to birth weight". (2022), 9-15. https://doi.org/10.18621/eurj.869966
APA Kadıoğlu B, Nalçakan A, Dilek E (2022). The paraoxonase 1 activity and lipid levels in umbilical cord blood and maternal venous blood, and their relations according to birth weight. The European Research Journal, 8(1), 9 - 15. 10.18621/eurj.869966
Chicago Kadıoğlu Berrin Göktuğ,Nalçakan Aysel,Dilek Esra The paraoxonase 1 activity and lipid levels in umbilical cord blood and maternal venous blood, and their relations according to birth weight. The European Research Journal 8, no.1 (2022): 9 - 15. 10.18621/eurj.869966
MLA Kadıoğlu Berrin Göktuğ,Nalçakan Aysel,Dilek Esra The paraoxonase 1 activity and lipid levels in umbilical cord blood and maternal venous blood, and their relations according to birth weight. The European Research Journal, vol.8, no.1, 2022, ss.9 - 15. 10.18621/eurj.869966
AMA Kadıoğlu B,Nalçakan A,Dilek E The paraoxonase 1 activity and lipid levels in umbilical cord blood and maternal venous blood, and their relations according to birth weight. The European Research Journal. 2022; 8(1): 9 - 15. 10.18621/eurj.869966
Vancouver Kadıoğlu B,Nalçakan A,Dilek E The paraoxonase 1 activity and lipid levels in umbilical cord blood and maternal venous blood, and their relations according to birth weight. The European Research Journal. 2022; 8(1): 9 - 15. 10.18621/eurj.869966
IEEE Kadıoğlu B,Nalçakan A,Dilek E "The paraoxonase 1 activity and lipid levels in umbilical cord blood and maternal venous blood, and their relations according to birth weight." The European Research Journal, 8, ss.9 - 15, 2022. 10.18621/eurj.869966
ISNAD Kadıoğlu, Berrin Göktuğ vd. "The paraoxonase 1 activity and lipid levels in umbilical cord blood and maternal venous blood, and their relations according to birth weight". The European Research Journal 8/1 (2022), 9-15. https://doi.org/10.18621/eurj.869966