Association of CDH1 -160 C → A and -347 G→ GA polymorphisms and expression of E-cadherin and gastric cancer: A case-control study
Yıl: 2021 Cilt: 1 Sayı: 37 Sayfa Aralığı: 41 - 48 Metin Dili: İngilizce DOI: 10.47717/turkjsurg.2021.5097 İndeks Tarihi: 13-05-2022
Association of CDH1 -160 C → A and -347 G→ GA polymorphisms and expression of E-cadherin and gastric cancer: A case-control study
Öz: Objective: The loss of function of the E-cadherin (CDH1) gene with -160 C→A and -347 G→GA polymorphisms is regarded as a critical step for gastric cancer. It was aimed to investigate possible association of these polymorphisms and immunoexpression of E-cadherin with gastric cancer. Material and Methods: Gastric adenocarcinoma patients and individuals with benign gastric pathologies were included in this case-control study. Demographic data and pathological findings were recorded. Immunohistochemical staining of E-cadherin expression and analysis of -160 C→A and -347 G→GA polymorphisms were done. Differences between allele frequencies of -160 C→A and -347 G→GA polymorphisms and expression of E-cadherin were the primary outcomes. Results: There were 78 gastric cancer patients (Group A) and 113 individuals with benign gastric pathologies (Group B). The number of male patients and mean age were higher in Group A (p< 0.001). -160 C→A and 347 G→GA polymorphisms and their allelic distributions showed no difference between the groups (p> 0.05 for all). There was a significant association between -160 C→A polymorphism and grade of E-cadherin expression (p= 0.013). There were no significant differences between survival rates with -160 C→A, 347 G→GA and intensity of E-cadherin expression (p> 0.05 for all). There was no significant association between -160 C→A and -347 G→GA polymorphisms and gastric cancer. Conclusion: There was no impact of E-cadherin expression on tumoral features and survival in gastric cancer. -160 C→A polymorphism may influence the expression of E-cadherin in gastric cancer.
Anahtar Kelime: CDH1 -160 C → A ve -347 G → GA polimorfizmleri ve E-kaderin ekspresyonunun mide kanseri ile ilişkisi: Bir vaka-kontrol çalışması
Öz: Giriş ve Amaç: E-kaderin (CDH1) geninin -160 C → A ve -347 G → GA polimorfizmleri ile fonksiyon kaybı, mide kanseri için kritik bir adım olarak kabul edilmektedir. Bu polimorfizmlerin ve E-kaderin immünekspresyonunun mide kanseri ile olası ilişkisinin araştırılması amaçlandı. Gereç ve Yöntem: Mide adenokarsinomu olan hastalar ve benign mide patolojileri olan bireyler bu vaka kontrol çalışmasına dahil edildi. Demografik veriler ve patolojik bulgular kaydedildi. E-kaderin ekspresyonunun immünohistokimyasal boyaması ve -160 C → A ve -347 G → GA polimorfizmlerinin analizi yapıldı. -160 C → A ve -347 G → GA polimorfizmlerinin allel frekansları ve E-kaderin ekspresyonu arasındaki farklar birincil sonuçlardı. Bulgular: 78 mide kanseri hastası (Grup A) ve benign mide patolojisi olan 113 birey (Grup B) vardı. Erkek hasta sayısı ve ortalama yaş grup A’da daha yüksekti (p< 0,001). -160 C → A ve 347 G → GA polimorfizmleri ve allelik dağılımları gruplar arasında fark göstermedi (tümü için p> 0,05). -160 C → A polimorfizmi ile E-kaderin ekspresyonunun derecesi arasında anlamlı bir ilişki vardı (p = 0,013). -160 C → A, 347 G → GA ile hayatta kalma oranları ve E-kaderin ekspresyonunun yoğunluğu arasında anlamlı fark yoktu (tümü için p> 0,05). -160 C → A ve -347 G → GA polimorfizmleri ve mide kanseri arasında anlamlı bir ilişki yoktu. Sonuç: E-kaderin ekspresyonunun tümör özellikleri ve mide kanserinin sağkalımı üzerine etkisi yoktu. -160 C → A polimorfizmi, mide kanserinde E-kaderin ekspresyonunu etkileyebilir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Akcakaya A, ünver n, Kiriş Aydoğan T, Güzel M, Akcakaya F, Cakmakoglu B, hasbahceci m (2021). Association of CDH1 -160 C → A and -347 G→ GA polymorphisms and expression of E-cadherin and gastric cancer: A case-control study. , 41 - 48. 10.47717/turkjsurg.2021.5097 |
| Chicago | Akcakaya Adem,ünver nurcan,Kiriş Aydoğan Tuğba,Güzel Mehmet,Akcakaya Fatma Betul,Cakmakoglu Bedia,hasbahceci mustafa Association of CDH1 -160 C → A and -347 G→ GA polymorphisms and expression of E-cadherin and gastric cancer: A case-control study. (2021): 41 - 48. 10.47717/turkjsurg.2021.5097 |
| MLA | Akcakaya Adem,ünver nurcan,Kiriş Aydoğan Tuğba,Güzel Mehmet,Akcakaya Fatma Betul,Cakmakoglu Bedia,hasbahceci mustafa Association of CDH1 -160 C → A and -347 G→ GA polymorphisms and expression of E-cadherin and gastric cancer: A case-control study. , 2021, ss.41 - 48. 10.47717/turkjsurg.2021.5097 |
| AMA | Akcakaya A,ünver n,Kiriş Aydoğan T,Güzel M,Akcakaya F,Cakmakoglu B,hasbahceci m Association of CDH1 -160 C → A and -347 G→ GA polymorphisms and expression of E-cadherin and gastric cancer: A case-control study. . 2021; 41 - 48. 10.47717/turkjsurg.2021.5097 |
| Vancouver | Akcakaya A,ünver n,Kiriş Aydoğan T,Güzel M,Akcakaya F,Cakmakoglu B,hasbahceci m Association of CDH1 -160 C → A and -347 G→ GA polymorphisms and expression of E-cadherin and gastric cancer: A case-control study. . 2021; 41 - 48. 10.47717/turkjsurg.2021.5097 |
| IEEE | Akcakaya A,ünver n,Kiriş Aydoğan T,Güzel M,Akcakaya F,Cakmakoglu B,hasbahceci m "Association of CDH1 -160 C → A and -347 G→ GA polymorphisms and expression of E-cadherin and gastric cancer: A case-control study." , ss.41 - 48, 2021. 10.47717/turkjsurg.2021.5097 |
| ISNAD | Akcakaya, Adem vd. "Association of CDH1 -160 C → A and -347 G→ GA polymorphisms and expression of E-cadherin and gastric cancer: A case-control study". (2021), 41-48. https://doi.org/10.47717/turkjsurg.2021.5097 |
| APA | Akcakaya A, ünver n, Kiriş Aydoğan T, Güzel M, Akcakaya F, Cakmakoglu B, hasbahceci m (2021). Association of CDH1 -160 C → A and -347 G→ GA polymorphisms and expression of E-cadherin and gastric cancer: A case-control study. Turkish Journal of Surgery, 1(37), 41 - 48. 10.47717/turkjsurg.2021.5097 |
| Chicago | Akcakaya Adem,ünver nurcan,Kiriş Aydoğan Tuğba,Güzel Mehmet,Akcakaya Fatma Betul,Cakmakoglu Bedia,hasbahceci mustafa Association of CDH1 -160 C → A and -347 G→ GA polymorphisms and expression of E-cadherin and gastric cancer: A case-control study. Turkish Journal of Surgery 1, no.37 (2021): 41 - 48. 10.47717/turkjsurg.2021.5097 |
| MLA | Akcakaya Adem,ünver nurcan,Kiriş Aydoğan Tuğba,Güzel Mehmet,Akcakaya Fatma Betul,Cakmakoglu Bedia,hasbahceci mustafa Association of CDH1 -160 C → A and -347 G→ GA polymorphisms and expression of E-cadherin and gastric cancer: A case-control study. Turkish Journal of Surgery, vol.1, no.37, 2021, ss.41 - 48. 10.47717/turkjsurg.2021.5097 |
| AMA | Akcakaya A,ünver n,Kiriş Aydoğan T,Güzel M,Akcakaya F,Cakmakoglu B,hasbahceci m Association of CDH1 -160 C → A and -347 G→ GA polymorphisms and expression of E-cadherin and gastric cancer: A case-control study. Turkish Journal of Surgery. 2021; 1(37): 41 - 48. 10.47717/turkjsurg.2021.5097 |
| Vancouver | Akcakaya A,ünver n,Kiriş Aydoğan T,Güzel M,Akcakaya F,Cakmakoglu B,hasbahceci m Association of CDH1 -160 C → A and -347 G→ GA polymorphisms and expression of E-cadherin and gastric cancer: A case-control study. Turkish Journal of Surgery. 2021; 1(37): 41 - 48. 10.47717/turkjsurg.2021.5097 |
| IEEE | Akcakaya A,ünver n,Kiriş Aydoğan T,Güzel M,Akcakaya F,Cakmakoglu B,hasbahceci m "Association of CDH1 -160 C → A and -347 G→ GA polymorphisms and expression of E-cadherin and gastric cancer: A case-control study." Turkish Journal of Surgery, 1, ss.41 - 48, 2021. 10.47717/turkjsurg.2021.5097 |
| ISNAD | Akcakaya, Adem vd. "Association of CDH1 -160 C → A and -347 G→ GA polymorphisms and expression of E-cadherin and gastric cancer: A case-control study". Turkish Journal of Surgery 1/37 (2021), 41-48. https://doi.org/10.47717/turkjsurg.2021.5097 |
