Isotretinoin, which is commonly used for the treatment of severe and treatment-resistant acne vulgaris, is associated with many adverse effects including musculoskeletal pain and arthralgia, and rarely sacroiliitis. Isotretinoin-induced sacroiliitis is typically limited with the discontinuation of isotretinoin and usually reduces with non-steroidal anti-inflammatory drugs. In this article, we present a patient using isotretinoin for her facial acne, lived inflammatory pain in her lower back and right hip region after 8 weeks of isotiretionin treatment and diagnosed sacroiliitis. As a result we want to draw attention to the fact that this drug can cause low back pain and sacroiliitis as a side effect.