Is there any contribution of bronchial washing to biopsy in the diagnosis of patients with endobronchial pathology in the era of personalized medicine?

karcıoğlu, oğuz; ONDER, SEVGEN ÇELIK; SARINC ULASLI, SEVINC; Sertçelik, Ümran; Keles, Emine; babaoglu, elif; Koksal, Deniz

doi:10.5578/tt.20219702

Is there any contribution of bronchial washing to biopsy in the diagnosis of patients with endobronchial pathology in the era of personalized medicine?

Oğuz KARCIOĞLU, (Hacettepe Üniversitesi, Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Sevinc SARİNC ULASLİ, (Hacettepe Üniversitesi, Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Elif BABAOGLU, (Hacettepe Üniversitesi, Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Emine KELEŞ, (Suşehri Devlet Hastanesi, Göğüs Hastalıkları Kliniği, Sivas, Türkiye)

Ümran ÖZDEN SERTÇELİK, (Ankara Şehir Hastanesi, Göğüs Hastalıkları Kliniği, Ankara, Türkiye)

Sevgen ÖNDER, (Hacettepe Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Ankara, Türkiye)

Deniz KÖKSAL (Hacettepe Üniversitesi, Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Tüberküloz ve Toraks

3 1

Yıl: 2021 Cilt: 69 Sayı: 3 Sayfa Aralığı: 307 - 313 Metin Dili: İngilizce DOI: 10.5578/tt.20219702 İndeks Tarihi: 14-05-2022

Is there any contribution of bronchial washing to biopsy in the diagnosis of patients with endobronchial pathology in the era of personalized medicine?

Öz:

Introduction: Bronchoscopic biopsies and bronchial washings (BW) are commonly used together for the diagnosis of centrally located tumors. This study aimed to investigate the clinical relevance of routinely collecting BWs in patients who simultaneously had biopsies for visible endobronchial lesions in the current molecular analysis-driven personalized medicine era. Materials and Methods: We retrospectively reviewed the patients who underwent fiberoptic bronchoscopy (FOB) between October 2011 and December 2016. Patients who had both BW and biopsy specimens (EBB: endobronchial forceps biopsy and/or EBNA: endobronchial needle aspiration biopsy) for visible endobronchial lesions were included in this study. Demographic and clinical data, macroscopic findings during FOB, pathology results, and final diagnoses were collected from the hospital database. Results: The study included 269 patients (220 males/49 females) with a mean age of 61.6 ± 10.6 years. While the overall diagnostic yield of FOB was 71.4%, the diagnostic yields of bronchoscopic procedures were 68.2% for EBB, 83.3% for EBNA, and 19.7% for BW. Only three patients (1.1%) with undiagnostic biopsies had positive BW cytology revealing merely malignant epithelial cells. Conclusion: BW provided a negligible diagnostic contribution in 1.1% (n= 3) of the patients. These three patients had undergone further diagnostic procedures for making a proper therapeutic management plan. In the era of personalized therapy, it is logical to obtain more biopsy in the time spent for BWs.

Anahtar Kelime:

Kişiselleştirilmiş tedavi çağında endobronşiyal patolojili hastaların tanısında bronşiyal yıkamanın biyopsiye katkısı var mı?

Öz:

Giriş: Bronkoskopik biyopsiler ve bronşiyal yıkamalar (BY) santral yerleşimli tümörlerin tanısında yaygın olarak birlikte kullanılmaktadır. Bu çalışma, kişiselleştirilmiş tıp çağında, görülebilir endobronşiyal lezyonlar için biyopsi alınan hastalarda rutin olarak BY alınmasının tanıya katkısını araştırmayı amaçlamaktadır. Materyal ve Metod: Ekim 2011 ile Aralık 2016 arasında fiberoptik bronkoskopi (FOB) yapılan hastalar geriye dönük olarak incelenmiştir. Görülebilir endobronşiyal lezyon için hem BY hem de biyopsi örnekleri (EBB: endobronşiyal forseps biyopsisi ve/veya EBNA: endobronşiyal iğne aspirasyonu) olan hastalar bu çalışmaya dahil edilmiştir. Hastane veri tabanından demografik ve klinik veriler, FOB sırasındaki makroskopik bulgular, patoloji sonuçları ve son tanılar toplanmıştır. Bulgular: Çalışmaya katılan 269 hastanın (220 erkek/49 kadın) yaş ortalaması 61,6 ± 10,6 yıl olarak bulunmuştur. FOB’nin genel tanısal katkısı %71,4 iken, bronkoskopik işlemlerin tanısal katkıları EBB için %68,2; EBNA için %83,3 ve BY için %19,7 olarak saptanmıştır. Sadece üç hastada (%1,1) biyopsi tanısal olmamasına rağmen, BY sitolojisinde malign epitel hücreler görülmüştür. Sonuç: BY’nin tanısal katkısı ihmal edilebilir düzeydedir (n= 3) (%1,1). Bu üç hastanın tanısı, uygun bir terapötik yönetim planı yapmak için daha ileri tanısal yöntemleriyle teyit edilmiştir. Kişiselleştirilmiş tıp çağında, BY’ler için harcanan zamanda daha fazla biyopsi almak uygun görünmektedir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	karcıoğlu o, SARINC ULASLI S, babaoglu e, Keles E, Sertçelik Ü, ONDER S, Koksal D (2021). Is there any contribution of bronchial washing to biopsy in the diagnosis of patients with endobronchial pathology in the era of personalized medicine?. , 307 - 313. 10.5578/tt.20219702
Chicago	karcıoğlu oğuz,SARINC ULASLI SEVINC,babaoglu elif,Keles Emine,Sertçelik Ümran,ONDER SEVGEN ÇELIK,Koksal Deniz Is there any contribution of bronchial washing to biopsy in the diagnosis of patients with endobronchial pathology in the era of personalized medicine?. (2021): 307 - 313. 10.5578/tt.20219702
MLA	karcıoğlu oğuz,SARINC ULASLI SEVINC,babaoglu elif,Keles Emine,Sertçelik Ümran,ONDER SEVGEN ÇELIK,Koksal Deniz Is there any contribution of bronchial washing to biopsy in the diagnosis of patients with endobronchial pathology in the era of personalized medicine?. , 2021, ss.307 - 313. 10.5578/tt.20219702
AMA	karcıoğlu o,SARINC ULASLI S,babaoglu e,Keles E,Sertçelik Ü,ONDER S,Koksal D Is there any contribution of bronchial washing to biopsy in the diagnosis of patients with endobronchial pathology in the era of personalized medicine?. . 2021; 307 - 313. 10.5578/tt.20219702
Vancouver	karcıoğlu o,SARINC ULASLI S,babaoglu e,Keles E,Sertçelik Ü,ONDER S,Koksal D Is there any contribution of bronchial washing to biopsy in the diagnosis of patients with endobronchial pathology in the era of personalized medicine?. . 2021; 307 - 313. 10.5578/tt.20219702
IEEE	karcıoğlu o,SARINC ULASLI S,babaoglu e,Keles E,Sertçelik Ü,ONDER S,Koksal D "Is there any contribution of bronchial washing to biopsy in the diagnosis of patients with endobronchial pathology in the era of personalized medicine?." , ss.307 - 313, 2021. 10.5578/tt.20219702
ISNAD	karcıoğlu, oğuz vd. "Is there any contribution of bronchial washing to biopsy in the diagnosis of patients with endobronchial pathology in the era of personalized medicine?". (2021), 307-313. https://doi.org/10.5578/tt.20219702

APA	karcıoğlu o, SARINC ULASLI S, babaoglu e, Keles E, Sertçelik Ü, ONDER S, Koksal D (2021). Is there any contribution of bronchial washing to biopsy in the diagnosis of patients with endobronchial pathology in the era of personalized medicine?. Tüberküloz ve Toraks, 69(3), 307 - 313. 10.5578/tt.20219702
Chicago	karcıoğlu oğuz,SARINC ULASLI SEVINC,babaoglu elif,Keles Emine,Sertçelik Ümran,ONDER SEVGEN ÇELIK,Koksal Deniz Is there any contribution of bronchial washing to biopsy in the diagnosis of patients with endobronchial pathology in the era of personalized medicine?. Tüberküloz ve Toraks 69, no.3 (2021): 307 - 313. 10.5578/tt.20219702
MLA	karcıoğlu oğuz,SARINC ULASLI SEVINC,babaoglu elif,Keles Emine,Sertçelik Ümran,ONDER SEVGEN ÇELIK,Koksal Deniz Is there any contribution of bronchial washing to biopsy in the diagnosis of patients with endobronchial pathology in the era of personalized medicine?. Tüberküloz ve Toraks, vol.69, no.3, 2021, ss.307 - 313. 10.5578/tt.20219702
AMA	karcıoğlu o,SARINC ULASLI S,babaoglu e,Keles E,Sertçelik Ü,ONDER S,Koksal D Is there any contribution of bronchial washing to biopsy in the diagnosis of patients with endobronchial pathology in the era of personalized medicine?. Tüberküloz ve Toraks. 2021; 69(3): 307 - 313. 10.5578/tt.20219702
Vancouver	karcıoğlu o,SARINC ULASLI S,babaoglu e,Keles E,Sertçelik Ü,ONDER S,Koksal D Is there any contribution of bronchial washing to biopsy in the diagnosis of patients with endobronchial pathology in the era of personalized medicine?. Tüberküloz ve Toraks. 2021; 69(3): 307 - 313. 10.5578/tt.20219702
IEEE	karcıoğlu o,SARINC ULASLI S,babaoglu e,Keles E,Sertçelik Ü,ONDER S,Koksal D "Is there any contribution of bronchial washing to biopsy in the diagnosis of patients with endobronchial pathology in the era of personalized medicine?." Tüberküloz ve Toraks, 69, ss.307 - 313, 2021. 10.5578/tt.20219702
ISNAD	karcıoğlu, oğuz vd. "Is there any contribution of bronchial washing to biopsy in the diagnosis of patients with endobronchial pathology in the era of personalized medicine?". Tüberküloz ve Toraks 69/3 (2021), 307-313. https://doi.org/10.5578/tt.20219702