Yıl: 2021 Cilt: 24 Sayı: 1 Sayfa Aralığı: 93 - 101 Metin Dili: İngilizce DOI: 10.9739/tjvs.2021.986 İndeks Tarihi: 15-05-2022

The effects of dexmedetomidine against ruptured abdominal aortic aneurysm injury to myocardial tissue induced by abdominal aorta clamping

Öz:
Objectives: This study aims to examine the potential protective effect of the selective alpha-2 adrenergic receptor agonist dexmedetomidine (DEX) against aortic occlusion-induced myocardial injury. Patients and methods: A total of 30 rats were randomly assigned into three groups of 10 animals each as control, ischemia+reperfusion (I/Rep), and I/Rep+DEX. In the I/Rep and I/Rep+DEX groups, after the completion of the shock stage, 60-min lower torso ischemia was induced with the application of cross-clamps to the abdominal aorta, followed by 120-min reperfusion. The I/Rep+DEX group received intraperitoneal 100 μg/kg DEX 30 min before the ischemia period. Results: Malondialdehyde (MDA) levels in myocardial tissue increased with the application of I/Rep, while glutathione (GSH) levels decreased. We also observed swollen, degenerative, apoptotic cardiac myofibrils exhibiting caspase-3 positivity, widespread edematous areas, vascular congestion, and an increase in the heart damage scores. The MDA levels decreased with DEX administration, while the GSH levels increased. Degenerative, apoptotic cardiac myofibrils exhibiting loss of cytoplasm content, and vascular congestion also decreased. Conclusion: Our study results suggest that DEX may have a future role in the treatment of myocardial damage occurring due to reperfusion, following ruptured abdominal aortic aneurysm surgery.
Anahtar Kelime:

Performance of mondial gala apple cultivars grafted on m9 apple rootstock in the Mediterranean region of Turkey

Öz:
Aims: This research was carried out on eight-year-old trees of the Mondial Gala (Malus domestica Borkh) cultivars grafted on the M9 rootstock in order to determine its performance in the Mediterranean region with subtropical climatic conditions in Mersin, Turkey. Methods and Results: In the study, the experiment was conducted in the orchard of private sector at Erdemli/Mersin. Mondial Gala which eight years, planted with planting spaces of 1x3 m flowering times, yield and fruit quality parameters were investigated. Conclusions: According to the results, first flowering was observed on April 1, full flowering on April 10 and end of flowering on April 17, and fruits were harvested at the end of July. The fruit weight (average 223.2 g), the yield per tree (average 22.6 kg), and yield per trunk cross-sectional area was observed as 0.56 kg/cm2 at the end of the eighth year. Observed values indicated that Mondial Gala summer apple cultivars were found to be promising for early apple growing in the higher parts of subtropical ecological conditions of Turkey. Significance and Impact of the Study: Phenological and pomological features of ‘Mondial Gala’ apple cultivar were evaluated at high altitudes of Mersin with subtropical climates of Turkey.
Anahtar Kelime:

M9 anacı üzerine aşılı mondial gala elma çeşidinin Akdeniz bölgesindeki performansı

Öz:
Amaç: M9 üzerine aşılı 3x1m aralıklarla dikilmiş 8 yaşlıMondial Gala (Malus domestica Borkh) çeşidinin Mersin(Türkiye) ilinde, subtropik iklim şartlarındakiperformansının saptanması amacıyla yürütülmüştür.Yöntem ve Bulgular: Mersin/erdemli ilçesinde özelsektöre ait bahçede çalışma yürütülmüştür. 1x3 m dikimmesafesiyle dikilmiş 8 yaşındaki Mondial Gala elmaçeşidinin çiçeklenme zamanı, verim ve meyve kaliteözellikleri araştırılmıştır.Genel Yorum: Mondial Gala çeşidinin ilk çiçeklenme 1Nisan, tam çiçeklenme 10 Nisan ve çiçeklenme sonu 17Nisan olarak gözlemlenmiştir. Meyveler Haziran’ınsonunda hasat edilmiştir. Ağaç başına verim 22.6 kg vegövde kesit alanına düşen verim 0.56 kg/cm2 olarakbelirlenmiştir. Ortalama meyve ağırlığı ise 223.2 g olaraksaptanmıştır. Elde edilen sonuçlar Mondial Gala elmaçeşidinin Akdeniz Bölgesinin yüksek kısımlarındaekonomik olarak yetiştirilebileceği göstermiştir.Çalışmanın Önemi ve Etkisi: Türkiye’nin subtropik iklimkuşağında bulunan Mersin ilçesinde yüksek rakımdabulunan Mondial Gala elma çeşidinin fenolojik ve pomolojik özelliklerinin belirlemek.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Karakişi O, bayazit s, Hemşinli D, Kilic D, Tumkaya L, Gunduz K, Ergene S, mercantepe t, yılmaz a (2021). The effects of dexmedetomidine against ruptured abdominal aortic aneurysm injury to myocardial tissue induced by abdominal aorta clamping. , 93 - 101. 10.9739/tjvs.2021.986
Chicago Karakişi Ozan,bayazit safder,Hemşinli Doğuş,Kilic Derya,Tumkaya Levent,Gunduz Kazim,Ergene Saban,mercantepe tolga,yılmaz adnan The effects of dexmedetomidine against ruptured abdominal aortic aneurysm injury to myocardial tissue induced by abdominal aorta clamping. (2021): 93 - 101. 10.9739/tjvs.2021.986
MLA Karakişi Ozan,bayazit safder,Hemşinli Doğuş,Kilic Derya,Tumkaya Levent,Gunduz Kazim,Ergene Saban,mercantepe tolga,yılmaz adnan The effects of dexmedetomidine against ruptured abdominal aortic aneurysm injury to myocardial tissue induced by abdominal aorta clamping. , 2021, ss.93 - 101. 10.9739/tjvs.2021.986
AMA Karakişi O,bayazit s,Hemşinli D,Kilic D,Tumkaya L,Gunduz K,Ergene S,mercantepe t,yılmaz a The effects of dexmedetomidine against ruptured abdominal aortic aneurysm injury to myocardial tissue induced by abdominal aorta clamping. . 2021; 93 - 101. 10.9739/tjvs.2021.986
Vancouver Karakişi O,bayazit s,Hemşinli D,Kilic D,Tumkaya L,Gunduz K,Ergene S,mercantepe t,yılmaz a The effects of dexmedetomidine against ruptured abdominal aortic aneurysm injury to myocardial tissue induced by abdominal aorta clamping. . 2021; 93 - 101. 10.9739/tjvs.2021.986
IEEE Karakişi O,bayazit s,Hemşinli D,Kilic D,Tumkaya L,Gunduz K,Ergene S,mercantepe t,yılmaz a "The effects of dexmedetomidine against ruptured abdominal aortic aneurysm injury to myocardial tissue induced by abdominal aorta clamping." , ss.93 - 101, 2021. 10.9739/tjvs.2021.986
ISNAD Karakişi, Ozan vd. "The effects of dexmedetomidine against ruptured abdominal aortic aneurysm injury to myocardial tissue induced by abdominal aorta clamping". (2021), 93-101. https://doi.org/10.9739/tjvs.2021.986
APA Karakişi O, bayazit s, Hemşinli D, Kilic D, Tumkaya L, Gunduz K, Ergene S, mercantepe t, yılmaz a (2021). The effects of dexmedetomidine against ruptured abdominal aortic aneurysm injury to myocardial tissue induced by abdominal aorta clamping. Turkish journal of vascular surgery, 24(1), 93 - 101. 10.9739/tjvs.2021.986
Chicago Karakişi Ozan,bayazit safder,Hemşinli Doğuş,Kilic Derya,Tumkaya Levent,Gunduz Kazim,Ergene Saban,mercantepe tolga,yılmaz adnan The effects of dexmedetomidine against ruptured abdominal aortic aneurysm injury to myocardial tissue induced by abdominal aorta clamping. Turkish journal of vascular surgery 24, no.1 (2021): 93 - 101. 10.9739/tjvs.2021.986
MLA Karakişi Ozan,bayazit safder,Hemşinli Doğuş,Kilic Derya,Tumkaya Levent,Gunduz Kazim,Ergene Saban,mercantepe tolga,yılmaz adnan The effects of dexmedetomidine against ruptured abdominal aortic aneurysm injury to myocardial tissue induced by abdominal aorta clamping. Turkish journal of vascular surgery, vol.24, no.1, 2021, ss.93 - 101. 10.9739/tjvs.2021.986
AMA Karakişi O,bayazit s,Hemşinli D,Kilic D,Tumkaya L,Gunduz K,Ergene S,mercantepe t,yılmaz a The effects of dexmedetomidine against ruptured abdominal aortic aneurysm injury to myocardial tissue induced by abdominal aorta clamping. Turkish journal of vascular surgery. 2021; 24(1): 93 - 101. 10.9739/tjvs.2021.986
Vancouver Karakişi O,bayazit s,Hemşinli D,Kilic D,Tumkaya L,Gunduz K,Ergene S,mercantepe t,yılmaz a The effects of dexmedetomidine against ruptured abdominal aortic aneurysm injury to myocardial tissue induced by abdominal aorta clamping. Turkish journal of vascular surgery. 2021; 24(1): 93 - 101. 10.9739/tjvs.2021.986
IEEE Karakişi O,bayazit s,Hemşinli D,Kilic D,Tumkaya L,Gunduz K,Ergene S,mercantepe t,yılmaz a "The effects of dexmedetomidine against ruptured abdominal aortic aneurysm injury to myocardial tissue induced by abdominal aorta clamping." Turkish journal of vascular surgery, 24, ss.93 - 101, 2021. 10.9739/tjvs.2021.986
ISNAD Karakişi, Ozan vd. "The effects of dexmedetomidine against ruptured abdominal aortic aneurysm injury to myocardial tissue induced by abdominal aorta clamping". Turkish journal of vascular surgery 24/1 (2021), 93-101. https://doi.org/10.9739/tjvs.2021.986