Bağırsak Mikrobiyotası ve İmmünogenetik

Oncul, Oral; Aktas, Zerrin; SAVRAN OGUZ, FATMA; GURER, EKIN ECE

doi:10.5578/flora.20219602

Bağırsak Mikrobiyotası ve İmmünogenetik

Ekin Ece GÜRER, (İstanbul Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, İstanbul, Türkiye)

Zerrin AKTAŞ, (İstanbul Üniversitesi, Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, İstanbul, Türkiye)

Fatma SAVRAN OĞUZ, (İstanbul Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, İstanbul, Türkiye)

Oral ÖNCÜ (İstanbul Üniversitesi, Tıp Fakültesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, İstanbul, Türkiye)

Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi

31 8

Yıl: 2021 Cilt: 26 Sayı: 4 Sayfa Aralığı: 573 - 583 Metin Dili: Türkçe DOI: 10.5578/flora.20219602 İndeks Tarihi: 16-05-2022

Bağırsak Mikrobiyotası ve İmmünogenetik

Öz:

İnsan mikrobiyotası, konakçının belirli yüzeylerinde (barsak, deri, ağız vb.) konumlanmıştır ve 1013 ile 1014 kadar mikroorganizmayaev sahipliği yapmaktadır. Bağırsak mikrobiyotası ürettikleri SCFA (“Short-Chain Fatty Acid”= SCFA)’lar ile insan fizyolojisinde, bağırsakmukozal bariyerinin yapısal bütünlüğünü koruyarak patojenlerin kolonizasyonunu engellemek, barsak-beyin ekseni iletişimine katılmak,bağışıklık sistemini hazırlamak ve besin sindirimine katkıda bulunmak gibi rollere sahiptir. Bağırsak mikrobiyotasının immün sistemleolan yakın ilişkisinin yanı sıra genetik faktörlerle de ilişkisi bulunur. MUC2, MyD88, IgA, NOD2, NLRP6 ve TLR5 gibi konakçı genlerdekimutasyonlar, bağırsak mikrobiyal kompozisyonu üzerinde önemli bir etkiye sahiptir ve bağırsak homeostazını veya disbiyozisi belirle yebilir. Konakçının bağışıklık sistemi bir ekosistem yöneticisi gibi çalışır ve mikrobiyal bileşimin çeşitliliğini kontrol etmede kritik bir roloynar. MHC (Major Histocompatibility Complex) genleri de dahil olmak üzere konağın immün sistemi ile ilgili genetik faktörler, bağırsakmikrobiyal kompozisyonu üzerinde güçlü bir etkiye sahiptir.

Anahtar Kelime:

Intestinal Microbiota and Immunogenetic

Öz:

Human microbiota is located on specific surfaces of the host (gut, skin, mouth, etc.), and includes 1013-1014 number of microorgan isms. Intestinal microbiota has roles such as preventing the colonization of pathogens by protecting the structural integrity of the intes tinal mucosal barrier, participating in the intestinal-brain axis communication, preparing the immune system for necessary situationsand contributing to food digestion in human physiology with the short-chain fatty acid (SCFA) they produce. Intestinal microbiota hasassociation with genetic factors in addition to its close relationship with the immune system. Mutations in host genes such as MUC2,MyD88, IgA, NOD2, NLRP6, and TLR5 have significant impact on gut microbial composition and can determine gut homeostasis ordysbiosis. The host’s immune system functions like an ecosystem manager and plays a critical role in controlling the diversity of microbial composition. Genetic factors related to the host’s immune system, including major histocompatibility complex (MHC) genes, have astrong effect on the gut microbial composition.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	GURER E, Aktas Z, SAVRAN OGUZ F, Oncul O (2021). Bağırsak Mikrobiyotası ve İmmünogenetik. , 573 - 583. 10.5578/flora.20219602
Chicago	GURER EKIN ECE,Aktas Zerrin,SAVRAN OGUZ FATMA,Oncul Oral Bağırsak Mikrobiyotası ve İmmünogenetik. (2021): 573 - 583. 10.5578/flora.20219602
MLA	GURER EKIN ECE,Aktas Zerrin,SAVRAN OGUZ FATMA,Oncul Oral Bağırsak Mikrobiyotası ve İmmünogenetik. , 2021, ss.573 - 583. 10.5578/flora.20219602
AMA	GURER E,Aktas Z,SAVRAN OGUZ F,Oncul O Bağırsak Mikrobiyotası ve İmmünogenetik. . 2021; 573 - 583. 10.5578/flora.20219602
Vancouver	GURER E,Aktas Z,SAVRAN OGUZ F,Oncul O Bağırsak Mikrobiyotası ve İmmünogenetik. . 2021; 573 - 583. 10.5578/flora.20219602
IEEE	GURER E,Aktas Z,SAVRAN OGUZ F,Oncul O "Bağırsak Mikrobiyotası ve İmmünogenetik." , ss.573 - 583, 2021. 10.5578/flora.20219602
ISNAD	GURER, EKIN ECE vd. "Bağırsak Mikrobiyotası ve İmmünogenetik". (2021), 573-583. https://doi.org/10.5578/flora.20219602

APA	GURER E, Aktas Z, SAVRAN OGUZ F, Oncul O (2021). Bağırsak Mikrobiyotası ve İmmünogenetik. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, 26(4), 573 - 583. 10.5578/flora.20219602
Chicago	GURER EKIN ECE,Aktas Zerrin,SAVRAN OGUZ FATMA,Oncul Oral Bağırsak Mikrobiyotası ve İmmünogenetik. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi 26, no.4 (2021): 573 - 583. 10.5578/flora.20219602
MLA	GURER EKIN ECE,Aktas Zerrin,SAVRAN OGUZ FATMA,Oncul Oral Bağırsak Mikrobiyotası ve İmmünogenetik. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, vol.26, no.4, 2021, ss.573 - 583. 10.5578/flora.20219602
AMA	GURER E,Aktas Z,SAVRAN OGUZ F,Oncul O Bağırsak Mikrobiyotası ve İmmünogenetik. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi. 2021; 26(4): 573 - 583. 10.5578/flora.20219602
Vancouver	GURER E,Aktas Z,SAVRAN OGUZ F,Oncul O Bağırsak Mikrobiyotası ve İmmünogenetik. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi. 2021; 26(4): 573 - 583. 10.5578/flora.20219602
IEEE	GURER E,Aktas Z,SAVRAN OGUZ F,Oncul O "Bağırsak Mikrobiyotası ve İmmünogenetik." Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, 26, ss.573 - 583, 2021. 10.5578/flora.20219602
ISNAD	GURER, EKIN ECE vd. "Bağırsak Mikrobiyotası ve İmmünogenetik". Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi 26/4 (2021), 573-583. https://doi.org/10.5578/flora.20219602