Yıl: 2021 Cilt: 38 Sayı: 1 Sayfa Aralığı: 28 - 32 Metin Dili: İngilizce DOI: 10.4103/nsn.nsn_7_21 İndeks Tarihi: 16-05-2022

The Effects of Melatonin Treatment on Headache and Vasomotor Reactivity in Patients with Chronic Tension‑Type Headache

Öz:
Objectives: Chronic tension‑type headache (TTH) is a serious disease that disrupts quality of life. In this study, the effect of prophylactic oral melatonin treatment on headache and cerebral vasomotor reactivity (VMR) was investigated in patients diagnosed with chronic TTH per the International Classification of Headache Disorders criteria. Subjects and Methods: Twenty patients with chronic TTH and 20 healthy individuals were included in the study. The patients were administered a melatonin treatment at 3 mg/day for 12 weeks. The number of monthly painful days and pain severity were recorded with the “Visual Analog Scale” before and after the treatment. Cerebral VMR measurements were performed at baseline in the control group and in patients before and after the treatment. Results: The median number of monthly painful days was 20 (15–27) before the treatment and 10 (4– 18) after the treatment; the median pain severity score was 70.00 (45–80) before the treatment and 42.50 (15–75) after the treatment. The difference was statistically significant (P = 0.001). No statistically significant difference between the VMR values was observed (P > 0.05). Conclusions: Melatonin treatment was effective in reducing the pain severity and decreasing the number of monthly painful days in patients with chronic TTH but demonstrated no effect on the cerebral VMR. Keywords: Chronic tension‑type headache, melatonin, treatment, vasomotor reactivity
Anahtar Kelime:

Melatonin Tedavisinin Baş Ağrısı ve Vazomotor Üzerine Etkileri Kronik Gerilim Tipi Baş Ağrısı Olan Hastalarda Reaktivite

Öz:
Amaç: Kronik gerilim tipi baş ağrısı (TTH) ciddi bir hastalıktır. yaşam kalitesi. Bu çalışmada profilaktik oral melatonin tedavisinin hastalarda baş ağrısı ve serebral vazomotor reaktivite (VMR) araştırıldı. Uluslararası Baş Ağrısı Sınıflamasına göre kronik TTH teşhisi kondu Bozukluk kriterleri. Denekler ve Yöntemler: Kronik TTH'li 20 hasta ve Çalışmaya 20 sağlıklı birey dahil edildi. Hastalar uygulandı 12 hafta boyunca günde 3 mg melatonin tedavisi. Aylık ağrılı sayısı gün ve ağrı şiddeti “Görsel Analog Skala” ile kaydedildi ve tedaviden sonra. Serebral VMR ölçümleri başlangıçta kontrol grubu ve hastalarda tedavi öncesi ve sonrası. Sonuçlar: ortanca aylık ağrılı gün sayısı tedavi öncesi 20 (15-27) ve 10 (4- 18) tedaviden sonra; medyan ağrı şiddeti skoru daha önce 70,00 (45-80) idi. tedavi ve 42.50 (15-75) tedaviden sonra. Fark istatistiksel olarak önemli (P = 0,001). VMR arasında istatistiksel olarak anlamlı bir fark yok değerler gözlendi (P > 0.05). Sonuçlar: Melatonin tedavisi etkiliydi ağrı şiddetini azaltmada ve aylık ağrılı gün sayısını azaltmada kronik TTH'si olan ancak serebral VMR üzerinde hiçbir etki göstermeyen hastalarda. Anahtar Kelimeler: Kronik gerilim tipi baş ağrısı, melatonin, tedavi, vazomotor tepkisellik
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Eroğlu E, öztürk b, Özön A, KOÇ G, karadaş ö (2021). The Effects of Melatonin Treatment on Headache and Vasomotor Reactivity in Patients with Chronic Tension‑Type Headache . , 28 - 32. 10.4103/nsn.nsn_7_21
Chicago Eroğlu Erdal,öztürk bilgin,Özön Akçay Övünç,KOÇ Güray,karadaş ömer The Effects of Melatonin Treatment on Headache and Vasomotor Reactivity in Patients with Chronic Tension‑Type Headache . (2021): 28 - 32. 10.4103/nsn.nsn_7_21
MLA Eroğlu Erdal,öztürk bilgin,Özön Akçay Övünç,KOÇ Güray,karadaş ömer The Effects of Melatonin Treatment on Headache and Vasomotor Reactivity in Patients with Chronic Tension‑Type Headache . , 2021, ss.28 - 32. 10.4103/nsn.nsn_7_21
AMA Eroğlu E,öztürk b,Özön A,KOÇ G,karadaş ö The Effects of Melatonin Treatment on Headache and Vasomotor Reactivity in Patients with Chronic Tension‑Type Headache . . 2021; 28 - 32. 10.4103/nsn.nsn_7_21
Vancouver Eroğlu E,öztürk b,Özön A,KOÇ G,karadaş ö The Effects of Melatonin Treatment on Headache and Vasomotor Reactivity in Patients with Chronic Tension‑Type Headache . . 2021; 28 - 32. 10.4103/nsn.nsn_7_21
IEEE Eroğlu E,öztürk b,Özön A,KOÇ G,karadaş ö "The Effects of Melatonin Treatment on Headache and Vasomotor Reactivity in Patients with Chronic Tension‑Type Headache ." , ss.28 - 32, 2021. 10.4103/nsn.nsn_7_21
ISNAD Eroğlu, Erdal vd. "The Effects of Melatonin Treatment on Headache and Vasomotor Reactivity in Patients with Chronic Tension‑Type Headache ". (2021), 28-32. https://doi.org/10.4103/nsn.nsn_7_21
APA Eroğlu E, öztürk b, Özön A, KOÇ G, karadaş ö (2021). The Effects of Melatonin Treatment on Headache and Vasomotor Reactivity in Patients with Chronic Tension‑Type Headache . Neurological sciences and neurophysiology (Online), 38(1), 28 - 32. 10.4103/nsn.nsn_7_21
Chicago Eroğlu Erdal,öztürk bilgin,Özön Akçay Övünç,KOÇ Güray,karadaş ömer The Effects of Melatonin Treatment on Headache and Vasomotor Reactivity in Patients with Chronic Tension‑Type Headache . Neurological sciences and neurophysiology (Online) 38, no.1 (2021): 28 - 32. 10.4103/nsn.nsn_7_21
MLA Eroğlu Erdal,öztürk bilgin,Özön Akçay Övünç,KOÇ Güray,karadaş ömer The Effects of Melatonin Treatment on Headache and Vasomotor Reactivity in Patients with Chronic Tension‑Type Headache . Neurological sciences and neurophysiology (Online), vol.38, no.1, 2021, ss.28 - 32. 10.4103/nsn.nsn_7_21
AMA Eroğlu E,öztürk b,Özön A,KOÇ G,karadaş ö The Effects of Melatonin Treatment on Headache and Vasomotor Reactivity in Patients with Chronic Tension‑Type Headache . Neurological sciences and neurophysiology (Online). 2021; 38(1): 28 - 32. 10.4103/nsn.nsn_7_21
Vancouver Eroğlu E,öztürk b,Özön A,KOÇ G,karadaş ö The Effects of Melatonin Treatment on Headache and Vasomotor Reactivity in Patients with Chronic Tension‑Type Headache . Neurological sciences and neurophysiology (Online). 2021; 38(1): 28 - 32. 10.4103/nsn.nsn_7_21
IEEE Eroğlu E,öztürk b,Özön A,KOÇ G,karadaş ö "The Effects of Melatonin Treatment on Headache and Vasomotor Reactivity in Patients with Chronic Tension‑Type Headache ." Neurological sciences and neurophysiology (Online), 38, ss.28 - 32, 2021. 10.4103/nsn.nsn_7_21
ISNAD Eroğlu, Erdal vd. "The Effects of Melatonin Treatment on Headache and Vasomotor Reactivity in Patients with Chronic Tension‑Type Headache ". Neurological sciences and neurophysiology (Online) 38/1 (2021), 28-32. https://doi.org/10.4103/nsn.nsn_7_21