TY  - JOUR
TI  - Antibacterial Resistance in Healthcare-AssociatedGram-negative Infections: What Changed in thePast Two Decades?
AB  - Introduction: Antimicrobial resistance in healthcare-associated gram-negative microorganisms is rising. Monitoring antimicrobial resis tance is crucial for determining infection control programs and planning empirical treatment of patients. In this study, it was aimed todetermine the distribution of the causative gram-negative bacteria and monitor the antibiotic susceptibility changes of Pseudomonasaeruginosa, Acinetobacter baumanni, Klebsiella spp. and Escherichia coli. Materials and Methods: An active and targeted surveillance of healthcare-associated infections is conducted by the Infection ControlCommittee in high-risk and intensive care units of our hospital. In this study, these surveillance data were used to compare the distri bution and antimicrobial susceptibility patterns of gram-negative microorganisms causing healthcare-associated infection in followingperiods: January-July 1998, January-December 2008 and January-December 2019. Results: A total of 1635 gram-negative isolates were analyzed, of which 251 were in 1998, 888 in 2008 and 496 in 2019. The mostfrequent gram-negative bacteria were Acinetobacter baumanni, E. coli, Pseudomonas spp. and Klebsiella spp.. Prevalence of E. coliand Pseudomonas spp. decreased while the prevalence of Klebsiella spp. and Stenotrophomonas maltophilia increased over years.Antimicrobial susceptibilities of beta-lactams, quinolones and aminoglycosides among P. aeruginosa increased over years, only the sus ceptibility of piperacillin-tazobactam decreased. Among Klebsiella spp., beta-lactams and quinolones had a significant susceptibility lossduring the study period. While all Klebsiella isolates were susceptible to meropenem in 1998, only 60% were susceptible in 2019. Therewas a significant decrease in susceptibility of ceftazidime, ciprofloxacin and meropenem among E. coli isolates. All tested antibiotics lostsignificant susceptibility for A. baumanii isolates, especially from 1998 to 2008.Conclusion: Antimicrobial resistance has had an increasing trend for healthcare-associated isolates of Klebsiella spp., E. coli andAcinetobacter spp. during the last 20 years. Rising carbapenem resistance in Klebsiella spp. has become a major threat to patients inhealthcare setting.
AU  - AYSERT-YILDIZ, PINAR
AU  - Dizbay, Murat
AU  - GUZEL TUNCCAN, OZLEM
DO  - 10.5578/flora.20219616
PY  - 2021
JO  - Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi
VL  - 26
IS  - 4
SN  - 1300-932X
SP  - 704
EP  - 712
DB  - TRDizin
UR  - http://search/yayin/detay/505148
ER  -