Television series, which have a wide range of audience, have the ability to connect the audience to the screen with the imagination of the screenwriters and shooting techniques of the director whether they are inspired by real life stories or not. New TV series starting with a spot “adapted from real life stories” have recently been added especially to dramas which are fed from such areas as social events and cultural diversity. The aim of this study is to reveal how ‘reality’ is presented and how it is perceived by the viewer in these series which are described as tele-clinicalby drawing a general framework for dramatic series productions which are adaptations of real life stories and which have been appearing on TV channels in recent years. In this context, the study has been carried out in the light of qualitative research methods such as mise-en-scene analysis and semi-structured interview. The study focuses on the problematic through which codes the perception of 'reality' is created in the series “Kırmızı Oda/Red Room” which is called as a tele-clinical series and which is based on real life stories. As a result of the mise-en-scene analysis; it has been observed that, in addition to the scenario inspired by real life, ‘reality’ is manipulated through supportive elements such as close-up shooting, casting, ‘naturalness’ (make-up, costume, speech, etc.) and psychological emphasis. Meanwhile; as a result of the audience interviews, it has been observed that the story, mostly, and acting, partly are the factors that affect the perception of ‘reality’.