Prognostic Importance of DUSP22 (Dual Specificity Phosphatase 22) Gene Expression in Low-Grade Lymphomas
Yıl: 2021 Cilt: 5 Sayı: 4 Sayfa Aralığı: 327 - 331 Metin Dili: İngilizce DOI: 10.14744/ejmo.2021.59080 İndeks Tarihi: 17-05-2022
Prognostic Importance of DUSP22 (Dual Specificity Phosphatase 22) Gene Expression in Low-Grade Lymphomas
Öz: Objectives: Dual specificity phosphatase 22 (DUSP22) is a novel phosphatase and has been demonstrated to be a cancer suppressor gene associated with various biological and pathological processes. The aim of this study is to evaluate the prognostic importance of DUSP22 expression in low-grade lymphomas. Methods: Fluorescence in situ hybridization (FISH) was used to detect DUSP22 and 76 cases with indolent lymphoma were evaluated for DUSP22 expression. Thirty-nine had follicular lymphoma (FL), 30 had marginal zone lymphoma (MZL) and 7 had chronic lymphocytic leukemia (CLL). Results: DUSP22 expression was detected in 17 cases (22.3%). The mean overall survival (OS) was found to be longer in cases without DUSP22 compared to cases with DUSP22 expression while event-free survival (EFS) was not different between the cases according to the DUSP22 expression. In univariate analysis, stage (early-stage disease p=0.0001), gender (female p=0.009) and DUSP22 expression (p=0.018) were found to be independent prognostic factors according to Cox regression analysis. . Conclusion: There is no sufficient data about the clinical and/or prognostic significance of DUSP22 rearrangement in lymphomas except ALK (-) anaplastic large cell lymphoma. We found that DUSP22 is poor prognostic indicator in cases with low grade lymphomas.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Paydas S, kilic bagir e, Ergin M, Seydaoglu G, buyuksimsek m (2021). Prognostic Importance of DUSP22 (Dual Specificity Phosphatase 22) Gene Expression in Low-Grade Lymphomas. , 327 - 331. 10.14744/ejmo.2021.59080 |
| Chicago | Paydas Semra,kilic bagir emine,Ergin Melek,Seydaoglu Gulsah,buyuksimsek mahmut Prognostic Importance of DUSP22 (Dual Specificity Phosphatase 22) Gene Expression in Low-Grade Lymphomas. (2021): 327 - 331. 10.14744/ejmo.2021.59080 |
| MLA | Paydas Semra,kilic bagir emine,Ergin Melek,Seydaoglu Gulsah,buyuksimsek mahmut Prognostic Importance of DUSP22 (Dual Specificity Phosphatase 22) Gene Expression in Low-Grade Lymphomas. , 2021, ss.327 - 331. 10.14744/ejmo.2021.59080 |
| AMA | Paydas S,kilic bagir e,Ergin M,Seydaoglu G,buyuksimsek m Prognostic Importance of DUSP22 (Dual Specificity Phosphatase 22) Gene Expression in Low-Grade Lymphomas. . 2021; 327 - 331. 10.14744/ejmo.2021.59080 |
| Vancouver | Paydas S,kilic bagir e,Ergin M,Seydaoglu G,buyuksimsek m Prognostic Importance of DUSP22 (Dual Specificity Phosphatase 22) Gene Expression in Low-Grade Lymphomas. . 2021; 327 - 331. 10.14744/ejmo.2021.59080 |
| IEEE | Paydas S,kilic bagir e,Ergin M,Seydaoglu G,buyuksimsek m "Prognostic Importance of DUSP22 (Dual Specificity Phosphatase 22) Gene Expression in Low-Grade Lymphomas." , ss.327 - 331, 2021. 10.14744/ejmo.2021.59080 |
| ISNAD | Paydas, Semra vd. "Prognostic Importance of DUSP22 (Dual Specificity Phosphatase 22) Gene Expression in Low-Grade Lymphomas". (2021), 327-331. https://doi.org/10.14744/ejmo.2021.59080 |
| APA | Paydas S, kilic bagir e, Ergin M, Seydaoglu G, buyuksimsek m (2021). Prognostic Importance of DUSP22 (Dual Specificity Phosphatase 22) Gene Expression in Low-Grade Lymphomas. Eurasian Journal of Medicine and Oncology, 5(4), 327 - 331. 10.14744/ejmo.2021.59080 |
| Chicago | Paydas Semra,kilic bagir emine,Ergin Melek,Seydaoglu Gulsah,buyuksimsek mahmut Prognostic Importance of DUSP22 (Dual Specificity Phosphatase 22) Gene Expression in Low-Grade Lymphomas. Eurasian Journal of Medicine and Oncology 5, no.4 (2021): 327 - 331. 10.14744/ejmo.2021.59080 |
| MLA | Paydas Semra,kilic bagir emine,Ergin Melek,Seydaoglu Gulsah,buyuksimsek mahmut Prognostic Importance of DUSP22 (Dual Specificity Phosphatase 22) Gene Expression in Low-Grade Lymphomas. Eurasian Journal of Medicine and Oncology, vol.5, no.4, 2021, ss.327 - 331. 10.14744/ejmo.2021.59080 |
| AMA | Paydas S,kilic bagir e,Ergin M,Seydaoglu G,buyuksimsek m Prognostic Importance of DUSP22 (Dual Specificity Phosphatase 22) Gene Expression in Low-Grade Lymphomas. Eurasian Journal of Medicine and Oncology. 2021; 5(4): 327 - 331. 10.14744/ejmo.2021.59080 |
| Vancouver | Paydas S,kilic bagir e,Ergin M,Seydaoglu G,buyuksimsek m Prognostic Importance of DUSP22 (Dual Specificity Phosphatase 22) Gene Expression in Low-Grade Lymphomas. Eurasian Journal of Medicine and Oncology. 2021; 5(4): 327 - 331. 10.14744/ejmo.2021.59080 |
| IEEE | Paydas S,kilic bagir e,Ergin M,Seydaoglu G,buyuksimsek m "Prognostic Importance of DUSP22 (Dual Specificity Phosphatase 22) Gene Expression in Low-Grade Lymphomas." Eurasian Journal of Medicine and Oncology, 5, ss.327 - 331, 2021. 10.14744/ejmo.2021.59080 |
| ISNAD | Paydas, Semra vd. "Prognostic Importance of DUSP22 (Dual Specificity Phosphatase 22) Gene Expression in Low-Grade Lymphomas". Eurasian Journal of Medicine and Oncology 5/4 (2021), 327-331. https://doi.org/10.14744/ejmo.2021.59080 |
