Role of Radiotherapy in Kaposi’s Sarcoma: Review of the Literature

Tekin, Selcan; Arslan, Alaettin; Tezcan, Yilmaz; Altınışık İnan, Gonca; aral, ipek pinar; GÖÇER GÜROK, Neşe; aytac arslan, suheyla

doi:10.5505/tjo.2021.2563

Role of Radiotherapy in Kaposi’s Sarcoma: Review of the Literature

İpek ARAL, (Department of Radiation Oncology, Nevşehir State Hospital, Nevşehir-Turkey)

Gonca ALTINIŞIK İNAN, (Department of Radiation Oncology, Ankara Yıldırım Beyazıt University Faculty of Medicine, Ankara-Turkey)

Süheyla ARSLAN, (Department of Radiation Oncology, Ankara Yıldırım Beyazıt University Faculty of Medicine, Ankara-Turkey)

Selcan TEKİN, (Department of Radiation Oncology, Ankara Sanatoryum Hospital, Ankara-Turkey)

Nese GOCER GUROK, (Department of Dermatology, Elazığ Fethi Sekin City Hospital, Elazığ-Turkey)

Alaettin ARSLAN, (Department of Radiation Oncology, Kayseri City Hospital, Kayseri-Turkey)

Yılmaz TEZCAN (Department of Radiation Oncology, Ankara Yıldırım Beyazıt University Faculty of Medicine, Ankara-Turkey)

Türk Onkoloji Dergisi

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Yıl: 2021 Cilt: 36 Sayı: 3 Sayfa Aralığı: 389 - 400 Metin Dili: İngilizce DOI: 10.5505/tjo.2021.2563 İndeks Tarihi: 17-05-2022

Role of Radiotherapy in Kaposi’s Sarcoma: Review of the Literature

Öz:

Radiotherapy (RT) is an effective treatment for local palliation of Kaposi’s sarcoma. However, there is no standardized RT dose and technique. Usually, electrons or low-energy photons are used, and various bolus materials are utilized for better dose distribution. High treatment response rates have been reported in all RT schemes. When the literature is examined in terms of dose and schema, for cutaneous lesions, single fraction treatments <8 Gy are less effective in terms of complete response (CR), and more effective results were obtained in total doses of 20 Gy and above. A total of 15 Gy for oral lesions, 20 Gy in eyelid conjunctival and scrotal lesions, and 30 Gy for cutaneous lesions are recommended. Planning target volume margins are defined as 2 mm–5 mm for orthovoltage devices and 0.5–2 cm for other treatments. In this study, we aimed to review the RT studies presented in the literature.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

1. Becker G, Bottke D. Radiotherapy in the management of Kaposi’s sarcoma. Onkologie 2006;29(7):329–33.
2. GLOBOCAN 2018: Estimated Cancer Incidence, Mortality and Prevalence Worldwide; 2018. Available at: https://www.gco.iarc.fr/today/data/factsheets/populations/ 900-world-fact-sheets.pdf.
3. Dalla Pria A, Pinato DJ, Bracchi M, Bower M. Recent advances in HIV-associated Kaposi sarcoma. F1000Res 2019;8: F1000 Faculty Rev–970.
4. El-Mallawany NK, Villiera J, Kamiyango W, Peckham- Gregory EC, Scheurer ME, Allen CE, et al. Endemic Kaposi sarcoma in HIV-negative children and adolescents: An evaluation of overlapping and distinct clinical features in comparison with HIV-related disease. Infect Agent Cancer 2018;13:33.
5. Orem J. Cancer prevention and control: Kaposi’s sarcoma. Ecancermedicalscience 2019;13:951.
6. Lebbe C, Garbe C, Stratigos AJ, Harwood C, Peris K, Marmol VD, et al. Diagnosis and treatment of Kaposi’s sarcoma: European consensus-based interdisciplinary guideline (EDF/EADO/EORTC). Eur J Cancer 2019;114:117–27.
7. Cheng ST, Ke CL, Lee CH, Wu CS, Chen GS, Hu SC. Dermoscopic rainbow pattern in non-Kaposi sarcoma lesions reply. Br J Dermatol 2010;162(2):458–9.
8. Tsao MN, Sinclair E, Assaad D, Fialkov J, Antonyshyn O, Barnes E. Radiation therapy for the treatment of skin Kaposi sarcoma. Ann Palliat Med 2016;5(4):298– 302.
9. Fatahzadeh M. Kaposi sarcoma: Review and medical management update. Oral Surg Oral Med Oral Pathol Oral Radiol 2012;113(1):2–16.
10. Karakas Y, Aksoy S, Gullu HI. Kaposi’s sarcoma epidemiology, risk factors, staging and treatment: An overview. Acta Oncol Turc 2017;20:148–59.
11. Ruocco E, Ruocco V, Tornesello ML, Gambardella A, Wolf R, Buonaguro FM. Kaposi’s sarcoma: Etiology and pathogenesis, inducing factors, causal associations, and treatments: Facts and controversies. Clin Dermatol 2013;31(4):413–22.
12. Régnier-Rosencher E, Guillot B, Dupin N. Treatments for classic Kaposi sarcoma: A systematic review of the literature. J Am Acad Dermatol 2013;68(2):313–311.
13. Vangipuram R, Tyring SK. Epidemiology of Kaposi sarcoma: Review and description of the nonepidemic variant. Int J Dermatol 2019;58(5):538–42.
14. Dutz W, Stout AP. Kaposi’s sarcoma in infants and children. Cancer 1960;13:684–94.
15. Davies JN, Lothe F. Kaposi’s sarcoma in African children. Acta Unio Int Contra Cancrum 1962;18:394–9.
16. Slavin G, Cameron HM, Forbes C, Mitchell RM. Kaposi’s sarcoma in East African children: A report of 51 cases. J Pathol 1970;100(3):187–99.
17. Curtiss P, Strazzulla LC, Friedman-Kien AE. An update on Kaposi’s sarcoma: Epidemiology, pathogenesis and treatment. Dermatol Ther (Heidelb) 2016;6(4):465– 70.
18. Nicolini G, Abraham S, Fogliata A, Jordaan A, Clivio A, Vanetti E, et al. Critical appraisal of volumetric- modulated arc therapy compared with electrons for the radiotherapy of cutaneous Kaposi’s sarcoma of lower extremities with bone sparing. Br J Radiol 2013;86(1023):20120543.
19. Rabate C. Prise en charge du sarcome de Kaposi posttransplantation re´nale en ıˆle de France: Analyse re´trospective de 89 patients. Ann Dermatol Venereol 2013;140:404.
20. Hoffmann C, Sabranski M, Esser S. HIV-associated Kaposi’s sarcoma. Oncol Res Treat 2017;40(3):94–8.
21. Brambilla L, Bellinvia M, Tourlaki A, Scoppio B, Gaiani F, Boneschi V. Intralesional vincristine as first-line therapy for nodular lesions in classic Kaposi sarcoma: A prospective study in 151 patients. Br J Dermatol 2010;162(4):854–9.
22. Di Monta G, Caracò C, Benedetto L, La Padula S, Marone U, Tornesello ML, et al. Electrochemotherapy as “new standard of care” treatment for cutaneous Kaposi’s sarcoma. Eur J Surg Oncol 2014;40(1):61–6.
23. Latini A, Bonadies A, Trento E, Bultrini S, Cota C, Solivetti FM, et al. Effective treatment of Kaposi’s sarcoma by electrochemotherapy and intravenous bleomycin administration. Dermatol Ther 2012;25(2):214–8.
24. Curatolo P, Quaglino P, Marenco F, Mancini M, Nardò T, Mortera C, et al. Electrochemotherapy in the treatment of Kaposi sarcoma cutaneous lesions: A twocenter prospective phase II trial. Ann Surg Oncol 2012;19(1):192–8.
25. Di Lorenzo G. Update on classic Kaposi sarcoma therapy: New look at an old disease. Crit Rev Oncol Hematol 2008;68(3):242–9.
26. Kirova YM, Belembaogo E, Frikha H, Haddad E, Calitchi E, Levy E, et al. Radiotherapy in the management of epidemic Kaposi’s sarcoma: A retrospective study of 643 cases. Radiother Oncol 1998;46(1):19–22.
27. Caccialanza M, Marca S, Piccinno R, Eulisse G. Radiotherapy of classic and human immunodeficiency virus-related Kaposi’s sarcoma: Results in 1482 lesions. J Eur Acad Dermatol Venereol 2008;22(3):297–302.
28. Donato V, Guarnaccia R, Dognini J, de Pascalis G, Caruso C, Bellagamba R, et al. Radiation therapy in the treatment of HIV-related Kaposi’s sarcoma. Anticancer Res 2013;33(5):2153–7.
29. Akmansu M, Göksel F, Erpolat OP, Unsal D, Karahacıoğlu E, Bora H. The palliative radiotherapy of classic Kaposi’s sarcoma of foot region: Retrospective evaluation. UHOD 2011;3:147–52.
30. Teke F, Akkurt ZM, Yıldırım O, Teke M, Zincircioğlu SB. Evaluation of 14 patients performed radiotherapy due to Kaposi sarcoma. Dicle Med J 2015;42:326–30.
31. Kasper ME, Richter S, Warren N, Benda R, Shang C, Ouhib Z. Complete response of endemic Kaposi sarcoma lesions with high-dose-rate brachytherapy: Treatment method, results, and toxicity using skin surface applicators. Brachytherapy 2013;12(5):495–9.
32. Chang JH, Kim IH. Role of radiotherapy in local control of non-AIDS associated Kaposi’s sarcoma patients in Korea: A single institution experience. Radiat Oncol J 2012;30(4):153–7.
33. Park JM, Kim IH, Ye SJ, Kim K. Evaluation of treatment plans using various treatment techniques for the radiotherapy of cutaneous Kaposi’s sarcoma developed on the skin of feet. J Appl Clin Med Phys 2014;15(6):4970.
34. Niewald M, Rübe C. Kaposi’s sarcoma--radiotherapeutic aspects. Front Radiat Ther Oncol 2006;39:50–8.
35. Harrison M, Harrington KJ, Tomlinson DR, Stewart JS. Response and cosmetic outcome of two fractionation regimens for AIDS-related Kaposi’s sarcoma. Radiother Oncol 1998;46(1):23–8.
36. Stelzer KJ, Griffin TW. A randomized prospective trial of radiation therapy for AIDS-associated Kaposi’s sarcoma. Int J Radiat Oncol Biol Phys 1993;27(5):1057– 61.
37. Ruiz MÁ, Rivero JQ, García JL, Rodríguez JJ, Kavadoy YR, Carmona MF, et al. High-dose-rate brachytherapy in the treatment of skin Kaposi sarcoma. J Contemp Brachytherapy 2017;9(6):561–5.
38. Evans MD, Yassa M, Podgorsak EB, Roman TN, Schreiner LJ, Souhami L. Surface applicators for high dose rate brachytherapy in AIDS-related Kaposi’s sarcoma. Int J Radiat Oncol Biol Phys 1997;39(3):769-74.
39. Syndikus I, Vinall A, Rogers P, Spittle M. High dose rate microselectron moulds for Kaposi sarcoma of the palate. Radiother Oncol 1997;42(2):167–70.
40. Saw CB, Wen BC, Anderson K, Pennington E, Hussey DH. Dosimetric considerations of water-based bolus for irradiation of extremities. Med Dosim 1998;23(4):292–5.
41. Available at: http://www.londoncancer.org/media/ 76382/london-cancer-skin-radiotherapy-guidelines- 2013-v1.0.pdf.
42. Kandaz M, Bahat Z, Guler OC, Canyilmaz E, Melikoglu M, Yoney A. Radiotherapy in the management of classic Kaposi’s sarcoma: A single institution experience from Northeast Turkey. Dermatol Ther 2018;31(4):e12605.
43. Yildiz F, Genc M, Akyurek S, Cengiz M, Ozyar E, Selek U, et al. Radiotherapy in the management of Kaposi’s sarcoma: Comparison of 8 Gy versus 6 Gy. J Natl Med Assoc 2006;98(7):1136–9.
44. Singh NB, Lakier RH, Donde B. Hypofractionated radiation therapy in the treatment of epidemic Kaposi sarcoma--a prospective randomized trial. Radiother Oncol 2008;88(2):211–6.
45. Geara F, Le Bourgeois JP, Piedbois P, Pavlovitch JM, Mazeron JJ. Radiotherapy in the management of cutaneous epidemic Kaposi’s sarcoma. Int J Radiat Oncol Biol Phys 1991;21(6):1517–22.
46. Oysul K, Beyzadeoglu M, Surenkok S, Ozyigit G, Dirican B. A dose-response analysis for classical Kaposi’s sarcoma management by radiotherapy. Saudi Med J 2008;29(6):837-40.
47. Le Bourgeois JP, Frikha H, Piedbois P, Le Péchoux C, Martin L, Haddad E. Radiotherapy in the management of epidemic Kaposi’s sarcoma of the oral cavity, the eyelid and the genitals. Radiother Oncol 1994;30(3):263–6.
48. Piedbois P, Frikha H, Martin L, Levy E, Haddad E, Le Bourgeois JP. Radiotherapy in the management of epidemic Kaposi’s sarcoma. Int J Radiat Oncol Biol Phys 1994;30(5):1207–11.
49. Berson AM, Quivey JM, Harris JW, Wara WM. Radiation therapy for AIDS-related Kaposi’s Sarcoma. Int J Radiat Oncol Biol Phys 1990;19(3):569–75.
50. de Wit R, Smit WG, Veenhof KH, Bakker PJ, Oldenburger F, González DG. Palliative radiation therapy for AIDS-associated Kaposi’s sarcoma by using a single fraction of 800 cGy. Radiother Oncol 1990;19(2):131– 6.
51. Westermann VA, Müller RP, Adler M, Bendick C, Rasokat H. The radiotherapy of epidemic Kaposi’s sarcomas in AIDS patients. Strahlenther Onkol1990;166(11):705–9.
52. Cooper JS, Steinfeld AD, Lerch I. Intentions and outcomes in the radiotherapeutic management of epidemic Kaposi’s sarcoma. Int J Radiat Oncol Biol Phys 1991;20(3):419–22.
53. Plettenberg A, Janik I, Kolb H, Meigel W. Local therapy measures in HIV-associated Kaposi’s sarcoma with special reference to fractionation radiotherapy. Strahlenther Onkol 1991;167(4):208-13.
54. Chang LF, Reddy S, Shidnia H. Comparison of radiation therapy of classic and epidemic Kaposi’s sarcoma. Am J Clin Oncol 1992;15(3):200–6.
55. Ghabrial R, Quivey JM, Dunn JP Jr., Char DH. Radiation therapy of acquired immunodeficiency syndrome- related Kaposi’s sarcoma of the eyelids and conjunctiva. Arch Ophthalmol 1992;110(10):1423–6.
56. Piccinno R, Caccialanza M, Cusini M. Role of radiotherapy in the treatment of epidemic Kaposi’s sarcoma: Experience with sixty-five cases. J Am Acad Dermatol 1995;32:1000–3.
57. Stein ME, Lakier R, Spencer D, Dale J, Kuten A, MacPhail P, et al. Radiation therapy for non-AIDS associated (classic and endemic African) and epidemic Kaposi’s sarcoma. Int J Radiat Oncol Biol Phys 1994;28(3):613–9.
58. Metzmann U, Rösler HP, Kutzner J. The palliative radiotherapy of Kaposi’s sarcomas in AIDS patients. Strahlenther Onkol 1995;171(4):238–40.
59. Saran FH, Adamietz IA, Thilmann C, Mose S, Böttcher HD. HIV-associated cutaneous Kaposi’s sarcoma-- palliative local treatment by radiotherapy. Acta Oncol 1997;36(1):55–8.
60. Conill C, Alsina M, Verger E, Henríquez I. Radiation therapy in AIDS-related cutaneous Kaposi’s sarcoma. Dermatology 1997;195(1):40–2.
61. Caccialanza M, Piccinno R, Gnecchi L, Beretta M, Cusini M. Intracavitary contact X-ray therapy of oral HIV-associated Kaposi’s sarcoma. Int J STD AIDS 1997;8(9):581–4.
62. Gressen EL, Rosenstock JG, Xie Y, Corn BW. Palliative treatment of epidemic Kaposi sarcoma of the feet. Am J Clin Oncol 1999;22(3):286–90.
63. Huang KM, Hsu CH, Cheng JC, Lai MK, Jeng SC, Ting LL, et al. Radiotherapy of classic Kaposi’s sarcoma in Taiwan, an area where classic Kaposi’s sarcoma is not prevalent. Anticancer Res 2006;26(6C):4659–63.
64. Hauerstock D, Gerstein W, Vuong T. Results of radiation therapy for treatment of classic Kaposi sarcoma. J Cutan Med Surg 2009;13(1):18–21.

APA	aral i, Altınışık İnan G, aytac arslan s, Tekin S, GÖÇER GÜROK N, Arslan A, Tezcan Y (2021). Role of Radiotherapy in Kaposi’s Sarcoma: Review of the Literature. , 389 - 400. 10.5505/tjo.2021.2563
Chicago	aral ipek pinar,Altınışık İnan Gonca,aytac arslan suheyla,Tekin Selcan,GÖÇER GÜROK Neşe,Arslan Alaettin,Tezcan Yilmaz Role of Radiotherapy in Kaposi’s Sarcoma: Review of the Literature. (2021): 389 - 400. 10.5505/tjo.2021.2563
MLA	aral ipek pinar,Altınışık İnan Gonca,aytac arslan suheyla,Tekin Selcan,GÖÇER GÜROK Neşe,Arslan Alaettin,Tezcan Yilmaz Role of Radiotherapy in Kaposi’s Sarcoma: Review of the Literature. , 2021, ss.389 - 400. 10.5505/tjo.2021.2563
AMA	aral i,Altınışık İnan G,aytac arslan s,Tekin S,GÖÇER GÜROK N,Arslan A,Tezcan Y Role of Radiotherapy in Kaposi’s Sarcoma: Review of the Literature. . 2021; 389 - 400. 10.5505/tjo.2021.2563
Vancouver	aral i,Altınışık İnan G,aytac arslan s,Tekin S,GÖÇER GÜROK N,Arslan A,Tezcan Y Role of Radiotherapy in Kaposi’s Sarcoma: Review of the Literature. . 2021; 389 - 400. 10.5505/tjo.2021.2563
IEEE	aral i,Altınışık İnan G,aytac arslan s,Tekin S,GÖÇER GÜROK N,Arslan A,Tezcan Y "Role of Radiotherapy in Kaposi’s Sarcoma: Review of the Literature." , ss.389 - 400, 2021. 10.5505/tjo.2021.2563
ISNAD	aral, ipek pinar vd. "Role of Radiotherapy in Kaposi’s Sarcoma: Review of the Literature". (2021), 389-400. https://doi.org/10.5505/tjo.2021.2563

APA	aral i, Altınışık İnan G, aytac arslan s, Tekin S, GÖÇER GÜROK N, Arslan A, Tezcan Y (2021). Role of Radiotherapy in Kaposi’s Sarcoma: Review of the Literature. Türk Onkoloji Dergisi, 36(3), 389 - 400. 10.5505/tjo.2021.2563
Chicago	aral ipek pinar,Altınışık İnan Gonca,aytac arslan suheyla,Tekin Selcan,GÖÇER GÜROK Neşe,Arslan Alaettin,Tezcan Yilmaz Role of Radiotherapy in Kaposi’s Sarcoma: Review of the Literature. Türk Onkoloji Dergisi 36, no.3 (2021): 389 - 400. 10.5505/tjo.2021.2563
MLA	aral ipek pinar,Altınışık İnan Gonca,aytac arslan suheyla,Tekin Selcan,GÖÇER GÜROK Neşe,Arslan Alaettin,Tezcan Yilmaz Role of Radiotherapy in Kaposi’s Sarcoma: Review of the Literature. Türk Onkoloji Dergisi, vol.36, no.3, 2021, ss.389 - 400. 10.5505/tjo.2021.2563
AMA	aral i,Altınışık İnan G,aytac arslan s,Tekin S,GÖÇER GÜROK N,Arslan A,Tezcan Y Role of Radiotherapy in Kaposi’s Sarcoma: Review of the Literature. Türk Onkoloji Dergisi. 2021; 36(3): 389 - 400. 10.5505/tjo.2021.2563
Vancouver	aral i,Altınışık İnan G,aytac arslan s,Tekin S,GÖÇER GÜROK N,Arslan A,Tezcan Y Role of Radiotherapy in Kaposi’s Sarcoma: Review of the Literature. Türk Onkoloji Dergisi. 2021; 36(3): 389 - 400. 10.5505/tjo.2021.2563
IEEE	aral i,Altınışık İnan G,aytac arslan s,Tekin S,GÖÇER GÜROK N,Arslan A,Tezcan Y "Role of Radiotherapy in Kaposi’s Sarcoma: Review of the Literature." Türk Onkoloji Dergisi, 36, ss.389 - 400, 2021. 10.5505/tjo.2021.2563
ISNAD	aral, ipek pinar vd. "Role of Radiotherapy in Kaposi’s Sarcoma: Review of the Literature". Türk Onkoloji Dergisi 36/3 (2021), 389-400. https://doi.org/10.5505/tjo.2021.2563