THE VALIDITY OF THE SPESI SCORE IN MORTALITY PREDICTION AT FOUR-YEAR FOLLOW-UP OF PATIENTS WITH PULMONARY EMBOLISM AND AGED OVER 65 YEARS

Tuncay, Esin; Kanmaz, Dilek; mandal, tugba; Yentürk, Esin; DOGU, ELIF; Aras, Gülfidan; Boyuk, Ferit

doi:10.31086/tjgeri.2021.256

THE VALIDITY OF THE SPESI SCORE IN MORTALITY PREDICTION AT FOUR-YEAR FOLLOW-UP OF PATIENTS WITH PULMONARY EMBOLISM AND AGED OVER 65 YEARS

Esin TUNCAY, (Yedikule Göğüs Hastalıkları Eğitim ve Araştırma Hastanesi, Göğüs Hastalıkları, İstanbul, Türkiye)

Zehra Dilek KANMAZ, (Yedikule Göğüs Hastalıkları Eğitim ve Araştırma Hastanesi, Göğüs Hastalıkları, İstanbul, Türkiye)

Gülfidan ARAS, (Yedikule Göğüs Hastalıkları Eğitim ve Araştırma Hastanesi, Göğüs Hastalıkları, İstanbul, Türkiye)

Elif DOĞU, (Galatasaray Üniversitesi, Endüstri Mühendisliği Bölümü, İstanbul, Türkiye)

Tuğba MANDAL, (Yedikule Göğüs Hastalıkları Eğitim ve Araştırma Hastanesi, Göğüs Hastalıkları, İstanbul, Türkiye)

Esin YENTÜRK, (Yedikule Göğüs Hastalıkları Eğitim ve Araştırma Hastanesi, Göğüs Hastalıkları, İstanbul, Türkiye)

Ferit BÖYÜK (Yedikule Göğüs Hastalıkları Eğitim ve Araştırma Hastanesi, Göğüs Hastalıkları, İstanbul, Türkiye)

Türk Geriatri Dergisi

1 0

Yıl: 2021 Cilt: 24 Sayı: 4 Sayfa Aralığı: 585 - 598 Metin Dili: İngilizce DOI: 10.31086/tjgeri.2021.256 İndeks Tarihi: 18-05-2022

THE VALIDITY OF THE SPESI SCORE IN MORTALITY PREDICTION AT FOUR-YEAR FOLLOW-UP OF PATIENTS WITH PULMONARY EMBOLISM AND AGED OVER 65 YEARS

Öz:

Introduction: This study investigates the values of the simplified pulmonary embolism severity index score, its individual criteria, the size of the pulmonary artery in which thrombus was detected by computed tomographic angiography, and systolic pulmonary artery pressure in predicting 30-day, 90- day, and longer-term mortality for patients in two age groups (over and under 65 years of age). Materials and Method: This study evaluated the data of 303 patients. It was designed as a retrospective cohort study and was conducted between January 1, 2019 and March 9, 2019, with a four-year follow up (2011–2015). Results: The mean age of the patients is 57.42 ±17.02. Among the patients who died, the simplified pulmonary embolism severity index score was higher than those who survived (p < 0.005), and a correlation was detected between 30-day and 90-day mortality and the score. It was found that pulmonary artery localization with thrombus and pulmonary artery pressure measurement do not have a significant correlation with mortality. While the score is correlated with 30-day and 90-day mortality in the under-65 age group, there was no correlation between 30-day mortality and the score in the over-65 age group. However, 90- day mortality was correlated with the score in the over-65 age group. Conclusion: Although this study validates the score in estimating 30-day and 90-day mortality, it was not sensitive in predicting 30-day mortality in patients over 65 years of age. Moreover, it was not sensitive in the estimation of late mortality after 90 days for this age group.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Puurunen MK, Gona PN, Larson MG, Murabito JM, Magnani JW, O’Donnell CJ. Epidemiology of venous thromboembolism in the Framingham Heart Study. Thromb Res. 2016;145:27-33. (PMID: 27442716)
2. Kurkciyan I, Meron G, Sterz F et al. Pulmonary embolism as a cause of cardiac arrest: presentation and outcome. Arch Intern Med. 2000;160(10):1529-35. (PMID: 10826469)
3. Buller HR, Davidson BL, Decousus H et al. Subcutaneous fondaparinux versus intravenous unfractionated heparin in the initial treatment of pulmonary embolism. New England Journal of Medicine. 2003;349(18):1695-702. (PMID: 14585937)
4. Jiménez D, Aujesky D, Moores L et al. Simplification of the pulmonary embolism severity index for prognostication in patients with acute symptomatic pulmonary embolism. Archives of internal medicine. 2010;170(15):1383-9. (PMID: 20696966)
5. Klok FA, Mos IC, Nijkeuter M et al. Simplification of the revised Geneva score for assessing clinical probability of pulmonary embolism. Archives of internal medicine. 2008;168(19):2131-6. (PMID: 18955643)
6. Jiménez D, Lobo JL, Monreal M et al. Prognostic significance of multidetector CT in normotensive patients with pulmonary embolism: results of the protect study. Thorax. 2014;69(2):109-15. (PMID: 23525079)
7. Zwierzina D, Limacher A, Méan M et al. Prospective comparison of clinical prognostic scores in elder patients with a pulmonary embolism. Journal of thrombosis and haemostasis. 2012;10(11):2270-6. (PMID: 22985129)
8. Aujesky D, Obrosky DS, Stone RA et al. Derivation and validation of a prognostic model for pulmonary embolism. American journal of respiratory and critical care medicine. 2005;172(8):1041-6. (PMID: 16020800)
9. Giordano NJ, Jansson PS, Young MN, Hagan KA, Kabrhel C. Epidemiology, pathophysiology, stratification, and natural history of pulmonary embolism. Techniques in vascular and interventional radiology. 2017;20(3):135-40. (PMID: 29029707)
10. Barco S, Mahmoudpour SH, Valerio L et al. Trends in mortality related to pulmonary embolism in the European Region, 2000–15: analysis of vital registration data from the WHO Mortality Database. The Lancet Respiratory Medicine. 2020;8(3):277-87. (PMID: 31615719)
11. Jiménez D, de Miguel-Díez J, Guijarro R et al. Trends in the management and outcomes of acute pulmonary embolism: analysis from the RIETE registry. Journal of the American College of Cardiology. 2016;67(2):162-70. (PMID: 26791063)
12. Friz HP, Orenti A, Gelfi E et al. Predictors of medium- and long-term mortality in elderly patients with acute pulmonary embolism. Heliyon. 2020;6(9):e04857. (PMID: 32984589)
13. Ceylan N, Tasbakan S, Bayraktaroglu S et al. Predictors of clinical outcome in acute pulmonary embolism: Correlation of CT pulmonary angiography with clinical, echocardiography and laboratory findings. Academic radiology. 2011;18(1):47-53. (PMID: 21036631)
14. D’Alto M, Romeo E, Argiento P et al. Accuracy and precision of echocardiography versus right heart catheterization for the assessment of pulmonary hypertension. International journal of cardiology. 2013;168(4):4058-62. (PMID: 23890907)
15. Konstantinides SV, Meyer G, Becattini C et al. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS) The Task Force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC). European heart journal. 2020;41(4):543-603. (PMID: 31504429)
16. Mizuno A, Yamamoto T, Tanabe Y et al. Pulmonary embolism severity index and simplified pulmonary embolism severity index risk scores are useful to predict mortality in Japanese patients with pulmonary embolism. Circulation Journal. 2015:CJ-14-1433. (PMID: 25739720)
17. Alotaibi G, Wu C, Senthilselvan A, McMurtry MS. Short-and long-term mortality after pulmonary embolism in patients with and without cancer. Vascular Medicine. 2018;23(3):261-6. (PMID: 29521183)
18. Barco S, Valerio L, Ageno W et al. Age-sex specific pulmonary embolism-related mortality in the USA and Canada, 2000–18: an analysis of the WHO Mortality Database and of the CDC Multiple Cause of Death database. The Lancet Respiratory Medicine. 2021;9(1):33-42. (PMID: 33058771)
19. Gök G, Karadağ M, Çinar T, Nurkalem Z, Duman D. In-hospital and short-term predictors of mortality in patients with intermediate-high risk pulmonary embolism. Journal of cardiovascular and thoracic research. 2020;12(4):321. (PMID: 33510882)
20. Bach AG, Taute B-M, Baasai N et al. 30-day mortality in acute pulmonary embolism: prognostic value of clinical scores and anamnestic features. PloS one. 2016;11(2):e0148728. (PMID: 26866472)
21. Becattini C, Vedovati M, Pruszczyk P et al. Oxygen saturation or respiratory rate to improve risk stratification in hemodynamically stable patients with acute pulmonary embolism. Journal of Thrombosis and Haemostasis. 2018;16(12):2397-402. (PMID: 30251461)
22. Hariharan P, Dudzinski DM, Rosovsky R et al. Relation among clot burden, right-sided heart strain, and adverse events after acute pulmonary embolism. The American journal of cardiology. 2016;118(10):1568- 73. (PMID: 27742425)
23. Furlan A, Aghayev A, Chang C-CH et al. Short-term mortality in acute pulmonary embolism: clot burden and signs of right heart dysfunction at CT pulmonary angiography. Radiology. 2012;265(1):283-93. (PMID: 22993221)
24. Çalik Kütükçü E, Arikan H, Sağlam M et al. A comparison of activities of daily living in geriatric and non-geriatric patients with chronic obstructive pulmonary disease. Turkish Journal of Geriatrics. 2015;18(1):68-74 (WOS:000352641100012)
25. Dülger D, Albuz, Ö. Risk indices that predict in-hospital mortality of elderly patients. Turkish Journal of Medical Sciences, 2020;50(4): 969-977. (PMID: 32490649)
26. Duru S, Yüce GD, Kaplan T et al. Follow up results of 65 years of age or older patients with pulmonary embolism: retrospective evaluation of 127 patients. Turkish Journal of Geriatrics. 2013;16(3):292-298 (WOS:000326136800010)
27. Jara-Palomares L, Alfonso M, Maestre A et al. Comparison of seven prognostic tools to identify low-risk pulmonary embolism in patients aged< 50 years. Scientific reports. 2019;9(1):1-10. (PMID: 31882805)
28. Sandal A, Korkmaz ET, Aksu F et al. Performance of pulmonary embolism severity index in predicting long-term mortality after acute pulmonary embolism. Anatolian Journal of Cardiology. 2021;25:544- 54 (PMID: 34369882)

APA	Tuncay E, Kanmaz D, Aras G, DOGU E, mandal t, Yentürk E, Boyuk F (2021). THE VALIDITY OF THE SPESI SCORE IN MORTALITY PREDICTION AT FOUR-YEAR FOLLOW-UP OF PATIENTS WITH PULMONARY EMBOLISM AND AGED OVER 65 YEARS. , 585 - 598. 10.31086/tjgeri.2021.256
Chicago	Tuncay Esin,Kanmaz Dilek,Aras Gülfidan,DOGU ELIF,mandal tugba,Yentürk Esin,Boyuk Ferit THE VALIDITY OF THE SPESI SCORE IN MORTALITY PREDICTION AT FOUR-YEAR FOLLOW-UP OF PATIENTS WITH PULMONARY EMBOLISM AND AGED OVER 65 YEARS. (2021): 585 - 598. 10.31086/tjgeri.2021.256
MLA	Tuncay Esin,Kanmaz Dilek,Aras Gülfidan,DOGU ELIF,mandal tugba,Yentürk Esin,Boyuk Ferit THE VALIDITY OF THE SPESI SCORE IN MORTALITY PREDICTION AT FOUR-YEAR FOLLOW-UP OF PATIENTS WITH PULMONARY EMBOLISM AND AGED OVER 65 YEARS. , 2021, ss.585 - 598. 10.31086/tjgeri.2021.256
AMA	Tuncay E,Kanmaz D,Aras G,DOGU E,mandal t,Yentürk E,Boyuk F THE VALIDITY OF THE SPESI SCORE IN MORTALITY PREDICTION AT FOUR-YEAR FOLLOW-UP OF PATIENTS WITH PULMONARY EMBOLISM AND AGED OVER 65 YEARS. . 2021; 585 - 598. 10.31086/tjgeri.2021.256
Vancouver	Tuncay E,Kanmaz D,Aras G,DOGU E,mandal t,Yentürk E,Boyuk F THE VALIDITY OF THE SPESI SCORE IN MORTALITY PREDICTION AT FOUR-YEAR FOLLOW-UP OF PATIENTS WITH PULMONARY EMBOLISM AND AGED OVER 65 YEARS. . 2021; 585 - 598. 10.31086/tjgeri.2021.256
IEEE	Tuncay E,Kanmaz D,Aras G,DOGU E,mandal t,Yentürk E,Boyuk F "THE VALIDITY OF THE SPESI SCORE IN MORTALITY PREDICTION AT FOUR-YEAR FOLLOW-UP OF PATIENTS WITH PULMONARY EMBOLISM AND AGED OVER 65 YEARS." , ss.585 - 598, 2021. 10.31086/tjgeri.2021.256
ISNAD	Tuncay, Esin vd. "THE VALIDITY OF THE SPESI SCORE IN MORTALITY PREDICTION AT FOUR-YEAR FOLLOW-UP OF PATIENTS WITH PULMONARY EMBOLISM AND AGED OVER 65 YEARS". (2021), 585-598. https://doi.org/10.31086/tjgeri.2021.256

APA	Tuncay E, Kanmaz D, Aras G, DOGU E, mandal t, Yentürk E, Boyuk F (2021). THE VALIDITY OF THE SPESI SCORE IN MORTALITY PREDICTION AT FOUR-YEAR FOLLOW-UP OF PATIENTS WITH PULMONARY EMBOLISM AND AGED OVER 65 YEARS. Türk Geriatri Dergisi, 24(4), 585 - 598. 10.31086/tjgeri.2021.256
Chicago	Tuncay Esin,Kanmaz Dilek,Aras Gülfidan,DOGU ELIF,mandal tugba,Yentürk Esin,Boyuk Ferit THE VALIDITY OF THE SPESI SCORE IN MORTALITY PREDICTION AT FOUR-YEAR FOLLOW-UP OF PATIENTS WITH PULMONARY EMBOLISM AND AGED OVER 65 YEARS. Türk Geriatri Dergisi 24, no.4 (2021): 585 - 598. 10.31086/tjgeri.2021.256
MLA	Tuncay Esin,Kanmaz Dilek,Aras Gülfidan,DOGU ELIF,mandal tugba,Yentürk Esin,Boyuk Ferit THE VALIDITY OF THE SPESI SCORE IN MORTALITY PREDICTION AT FOUR-YEAR FOLLOW-UP OF PATIENTS WITH PULMONARY EMBOLISM AND AGED OVER 65 YEARS. Türk Geriatri Dergisi, vol.24, no.4, 2021, ss.585 - 598. 10.31086/tjgeri.2021.256
AMA	Tuncay E,Kanmaz D,Aras G,DOGU E,mandal t,Yentürk E,Boyuk F THE VALIDITY OF THE SPESI SCORE IN MORTALITY PREDICTION AT FOUR-YEAR FOLLOW-UP OF PATIENTS WITH PULMONARY EMBOLISM AND AGED OVER 65 YEARS. Türk Geriatri Dergisi. 2021; 24(4): 585 - 598. 10.31086/tjgeri.2021.256
Vancouver	Tuncay E,Kanmaz D,Aras G,DOGU E,mandal t,Yentürk E,Boyuk F THE VALIDITY OF THE SPESI SCORE IN MORTALITY PREDICTION AT FOUR-YEAR FOLLOW-UP OF PATIENTS WITH PULMONARY EMBOLISM AND AGED OVER 65 YEARS. Türk Geriatri Dergisi. 2021; 24(4): 585 - 598. 10.31086/tjgeri.2021.256
IEEE	Tuncay E,Kanmaz D,Aras G,DOGU E,mandal t,Yentürk E,Boyuk F "THE VALIDITY OF THE SPESI SCORE IN MORTALITY PREDICTION AT FOUR-YEAR FOLLOW-UP OF PATIENTS WITH PULMONARY EMBOLISM AND AGED OVER 65 YEARS." Türk Geriatri Dergisi, 24, ss.585 - 598, 2021. 10.31086/tjgeri.2021.256
ISNAD	Tuncay, Esin vd. "THE VALIDITY OF THE SPESI SCORE IN MORTALITY PREDICTION AT FOUR-YEAR FOLLOW-UP OF PATIENTS WITH PULMONARY EMBOLISM AND AGED OVER 65 YEARS". Türk Geriatri Dergisi 24/4 (2021), 585-598. https://doi.org/10.31086/tjgeri.2021.256