Keep in Mind: Pulmonary Embolism Due to the Use of Clomiphene Citrate
Yıl: 2021 Cilt: 10 Sayı: 2 Sayfa Aralığı: 126 - 129 Metin Dili: İngilizce DOI: 10.5505/respircase.2021.18291 İndeks Tarihi: 18-05-2022
Keep in Mind: Pulmonary Embolism Due to the Use of Clomiphene Citrate
Öz: A 28-year-old female patient was admitted with on- going chest pain for one day, having started treat- ment for ovulatory dysfunction with clomiphene cit- rate 20 days prior. The patient's pulse rate was 120 bpm and blood pressure was 100/60 mmHg. Sinus tachycardia was detected on electrocardiography. Both hypoxia and hypocapnia were detected on an arterial blood gas test. The patient’s d-dimer level was measured as 5.2 μg/ml. A computed tomogra- phy angiography revealed filling defects in the right lower lobe pulmonary artery and lower lobe segment branches, consistent with pulmonary embolism. The ejection fraction was 65% on the transthoracic echo- cardiography and no thrombus was observed. The patient was diagnosed with pulmonary embolism due to clomiphene citrate use, and started on anticoagu- lation therapy with bemiparin sodium, and was sub- sequently discharged. Acute pulmonary embolism due to the use of clomiphene citrate is an uncommon but life-threatening complication when encountered. Physicians should be aware of the potential risk of pulmonary embolism.
Anahtar Kelime: Aklınızda Bulunsun: Klomifen Sitrat Kullanımına Bağlı Pulmoner Emboli
Öz: Yirmi sekiz yaşındaki bayan hasta bir gündür devam eden göğüs ağrısı nedeniyle başvurdu. Ovulatuar disfonksiyonun klomifen sitrat ile tedavisi 20 gün önce başlatılmıştı. Hastanın nabız hızı 120 vuru / dakika ve kan basıncı 100/60 mmHg idi. Elektrokar- diyografide sinüs taşikardisi saptandı. Arteriyel kan gazı testi sonucunda hem hipoksi hem de hipokapni tespit edildi. D-dimer seviyesi 5.2 μg / ml olarak ölçüldü. Bilgisayarlı tomografi anjiyografisinde sağ alt lob pulmoner arter ve alt lob segment dallarında pulmoner emboli ile uyumlu dolum defektleri görül- dü. Transtorasik ekokardiyografide ejeksiyon fraksi- yonu %65 idi ve trombüs izlenmedi. Hastaya klomifen sitrat kullanımına bağlı pulmoner emboli tanısı kon- du. Bemiparin sodyum ile antikoagülan tedavi baş- landı ve hasta taburcu edildi. Klomifen sitrat kullanı- mına bağlı akut pulmoner emboli, nadir görülen ancak karşılaşıldığında yaşamı tehdit eden bir komp- likasyon olabilir. Doktorlar olası pulmoner emboli riskinin farkında olmalıdır.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık
- 1. Konstantinides SV, Meyer G, Becattini C, Bueno H, Geer- sing GJ, Harjola VP, et al. 2019 ESC Guidelines for the diagnosis and managementof acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS). Eur Heart J 2019; 21:543-603. [CrossRef]
- 2. Practice Committee of the American Society for Repro- ductive Medicine. Use of clomiphene citrate in women. Fertil Steril 2006; 86:187-93. [CrossRef]
- 3. Juan A Garcia-Velasco, Manish Banker; Infertility Mana- gement Series, Polycystic Ovarian Syndrome Diagnosis and Management, First Edition: 2017.
- 4. National Colloborating Centre for Women's and Child- ren's Health or National Institute for Health and Care Excellance. Fertility: assesment and treatment for people with fertility problems. London: RCOG Press; 2013.
- 5. Ekpo G, Moy I, Pavone ME, Milad MP. The use of clomi- phene citrate for ovulation induction: When, why, and how? Contemporary Ob/Gyn 2011: 56;42-52.
- 6. Yilmaz S, Unal F, Yilmaz E, Yuzbasıoglu D, Erkal-Ilhan S. Evaluation of the genotoxicity of clomiphene citrate. Mutat Res Genet Toxicol Environ Mutagen 2014; 759:21-7. [CrossRef]
- 7. Asmatullah SN, Ara C. Teratogenic and embryotoxic ef- fects of clomiphene citrate in developing mice. Asian Australas J Anim Sci 2011; 24:1053-9. [CrossRef]
- 8. Study of possible correlation between myocardial infarc- tion and clomiphene citrate. Acailable at: http://factmed.com/ study-clomiphene%20citrate- causing myocardial%20infarction. php. Accessed Apr 24, 2018.
- 9. Chamberlain RA, Cumming DC. Pulmonary embolism during clomiphene therapy for infertility in a male: a case report. Int J Fertil 1986; 31:198-9.
- 10. Benshushan A, Shushan A, Paltiel O, Mordel N, Laufer N. Ovulation induction with clomiphene citrate complicated by deep vein thrombosis. Eur J Obstet Gynecol Reprod Biol 1995; 62:261-2. [CrossRef]
- 11. Inbar OJ, Levran D, Mashiach S, Dor J. Ischemic stroke due to induction of ovulation with clomiphene citrate and menotropins without evidence of ovarian hyperstimulation syndrome. Fertil Steril 1994; 62:1075-6. [CrossRef]
- 12. Girolami A, Scandellari R, Tezza F, Paternoster D, Girolami B. Arterial thrombosis in young women after ovarian stimulation: case report and review of the litera- ture. J Thromb Thrombolysis 2007; 24:169-74. [CrossRef]
- 13. Arseven O, Ekim N, Müsellim B ve ark. Türk Toraks Derneği, Pulmoner Tromboembolizm Tanı ve Tedavi Uzlaşı Raporu - 2015. http://www.toraks.org.tr.
| APA | Mermi̇t B, YILDIZ H, Sunnetcioglu A (2021). Keep in Mind: Pulmonary Embolism Due to the Use of Clomiphene Citrate. , 126 - 129. 10.5505/respircase.2021.18291 |
| Chicago | Mermi̇t Buket,YILDIZ Hanifi,Sunnetcioglu Aysel Keep in Mind: Pulmonary Embolism Due to the Use of Clomiphene Citrate. (2021): 126 - 129. 10.5505/respircase.2021.18291 |
| MLA | Mermi̇t Buket,YILDIZ Hanifi,Sunnetcioglu Aysel Keep in Mind: Pulmonary Embolism Due to the Use of Clomiphene Citrate. , 2021, ss.126 - 129. 10.5505/respircase.2021.18291 |
| AMA | Mermi̇t B,YILDIZ H,Sunnetcioglu A Keep in Mind: Pulmonary Embolism Due to the Use of Clomiphene Citrate. . 2021; 126 - 129. 10.5505/respircase.2021.18291 |
| Vancouver | Mermi̇t B,YILDIZ H,Sunnetcioglu A Keep in Mind: Pulmonary Embolism Due to the Use of Clomiphene Citrate. . 2021; 126 - 129. 10.5505/respircase.2021.18291 |
| IEEE | Mermi̇t B,YILDIZ H,Sunnetcioglu A "Keep in Mind: Pulmonary Embolism Due to the Use of Clomiphene Citrate." , ss.126 - 129, 2021. 10.5505/respircase.2021.18291 |
| ISNAD | Mermi̇t, Buket vd. "Keep in Mind: Pulmonary Embolism Due to the Use of Clomiphene Citrate". (2021), 126-129. https://doi.org/10.5505/respircase.2021.18291 |
| APA | Mermi̇t B, YILDIZ H, Sunnetcioglu A (2021). Keep in Mind: Pulmonary Embolism Due to the Use of Clomiphene Citrate. Respiratory Case Reports, 10(2), 126 - 129. 10.5505/respircase.2021.18291 |
| Chicago | Mermi̇t Buket,YILDIZ Hanifi,Sunnetcioglu Aysel Keep in Mind: Pulmonary Embolism Due to the Use of Clomiphene Citrate. Respiratory Case Reports 10, no.2 (2021): 126 - 129. 10.5505/respircase.2021.18291 |
| MLA | Mermi̇t Buket,YILDIZ Hanifi,Sunnetcioglu Aysel Keep in Mind: Pulmonary Embolism Due to the Use of Clomiphene Citrate. Respiratory Case Reports, vol.10, no.2, 2021, ss.126 - 129. 10.5505/respircase.2021.18291 |
| AMA | Mermi̇t B,YILDIZ H,Sunnetcioglu A Keep in Mind: Pulmonary Embolism Due to the Use of Clomiphene Citrate. Respiratory Case Reports. 2021; 10(2): 126 - 129. 10.5505/respircase.2021.18291 |
| Vancouver | Mermi̇t B,YILDIZ H,Sunnetcioglu A Keep in Mind: Pulmonary Embolism Due to the Use of Clomiphene Citrate. Respiratory Case Reports. 2021; 10(2): 126 - 129. 10.5505/respircase.2021.18291 |
| IEEE | Mermi̇t B,YILDIZ H,Sunnetcioglu A "Keep in Mind: Pulmonary Embolism Due to the Use of Clomiphene Citrate." Respiratory Case Reports, 10, ss.126 - 129, 2021. 10.5505/respircase.2021.18291 |
| ISNAD | Mermi̇t, Buket vd. "Keep in Mind: Pulmonary Embolism Due to the Use of Clomiphene Citrate". Respiratory Case Reports 10/2 (2021), 126-129. https://doi.org/10.5505/respircase.2021.18291 |
