Yıl: 2021 Cilt: 10 Sayı: 2 Sayfa Aralığı: 143 - 147 Metin Dili: İngilizce DOI: 10.5505/respircase.2021.57689 İndeks Tarihi: 18-05-2022

Spurious Hypoxemia in an Intensive Care Patient with Hyperleukocytosis Secondary to Acute Leukem

Öz:
A rare phenomenon that can occur in intensive care patients with hyperleukocytosis has been identified that is known as “spurious hypoxemia” in arterial blood gas analyses. Hyperleukocytosis is a common cause of spurious hypoxemia. A 53-year-old male patient who was newly diagnosed with acute myeloid leukemia, and who had no known chronic disease or drug use, presented with complaints of weakness, swelling of the hands and blood spitting, and is re- ported on here in the light of the literature due to the inconsistency between the peripheral oxygen satura- tion and arterial blood gas values. The aim in pre- senting this case report is to emphasize the im- portance of spurious hypoxemia in patients in which hypoxemia may be expected, but who are not actual- ly hypoxemic, for the determination of a treatment procedure.
Anahtar Kelime:

Akut Lösemiye Sekonder Hiperlökositozlu Bir Yoğun Bakım Hastasında Sahte Hipoksemi

Öz:
Hiperlökositozlu yoğun bakım hastalarında ortaya çıkabilen ve arteriyel kan gazı analizlerinde "sahte hipoksemi" olarak adlandırılılan nadir bir fenomen tanımlanmıştır. Hiperlökositoz, sahte hipokseminin yaygın bir nedenidir. Bilinen kronik hastalığı ve ilaç kullanımı olmayan, halsizlik, ellerde şişme, kan tü- kürme şikayetiyle başvuran 53 yaşında, yeni tanı akut myeloid lösemili erkek hasta, periferik oksijen satü- rasyonu ile arteriyel kan gazı değerleri arasındaki uyumsuzluk nedeniyle literatür ışığında sunulmuştur. Bu olgu sunumunun amacı, hipokseminin gerçekten beklenebileceği ancak gerçekte hipoksemik olmayan hastalarda tedavi prosedürünü belirlemede, sahte hipokseminin önemini vurgulamaktır.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık
  • 1. Würthner JU, Köhler G, Behringer D, Lindemann A, Mer- telsmann R, Lübbert M. Leukostasis followed by hemorr- hage complicating the initiation of chemotherapy in pati- ents with acute myeloid leukemia and hyperleukocytosis: a clinicopathologic report of four cases. Cancer 1999; 85:368-74. [CrossRef]
  • 2. Khoo SM, Lee KH, Notley M. Spurious hypoxaemia in a patient with leukaemia and extreme leucocytosis. Singa- pore Med J 2003; 44:208-10.
  • 3. Gorski TF, Ajemian M, Hussain E, Talhouk A, Ruskin G, Hanna A, et al. Correlation of pseudohypoxemia and leukocytosis in chronic lymphocytic leukemia. South Med J 1999; 92:817-9. [CrossRef]
  • 4. Mizock BA, Franklin C, Lindesmith P, Shah PC. Confir- mation of spurious hypoxemia using continuous blood gas analysis in a patient with chronic myelogenous leu- kemia. Leuk Res 1995; 19:1001-4. [CrossRef]
  • 5. Chillar RK, Belman MJ, Farbstein M. Explanation for ap- parent hypoxemia associated with extreme leukocytosis: leukocytic oxygen consumption. Blood 1980; 55: 922-4. [CrossRef]
  • 6. Aygencel G. Interpretation of arterial blood gases Arch Turk Soc Cardiol 2014; 42:194-202. [CrossRef] 7. Gartrell K, Rosenstrauch W. Hypoxaemia in patients with hyperleukocytosis: true or spurious, and clinical implica- tions. Leuk Res 1993; 17:915-9. [CrossRef]
  • 8. Angulo M, Machado D, Larrosa L, Biestro A. Real and spurious hypoxemia in a patient with extreme hyperleu- kocytosis. Med Intensiva 2019; 43:435-6. [CrossRef]
  • 9. Lele AV, Marek A Mirski, Robert D Stevens. Spurious hy- poxemia Crit Care Med 2005; 33:1854-6. [CrossRef]
  • 10. Porcu P, Cripe LD, Ng EW, Bhatia S, Danielson CM, Orazi A, et al. Hyperleukocytic leukemias and leukostasis: a review of pathophysiology, clinical presentation and management. Leuk Lymphoma 2000; 39:1-18. [CrossRef]
  • 11. Lester TJ, Johnson JW, Cuttner J. Pulmonary leukostasis as the single worst prognostic factor in patients with acute myelocytic leukemia and hyperleukocytosis. Am J Med 1985; 79:43-8. [CrossRef]
APA HEKİMOĞLU M, Ayaydın Mürtezaoğlu S, PEHLİVANLAR KÜÇÜK M (2021). Spurious Hypoxemia in an Intensive Care Patient with Hyperleukocytosis Secondary to Acute Leukem. , 143 - 147. 10.5505/respircase.2021.57689
Chicago HEKİMOĞLU Muhammet Faruk,Ayaydın Mürtezaoğlu Sevil,PEHLİVANLAR KÜÇÜK Mehtap Spurious Hypoxemia in an Intensive Care Patient with Hyperleukocytosis Secondary to Acute Leukem. (2021): 143 - 147. 10.5505/respircase.2021.57689
MLA HEKİMOĞLU Muhammet Faruk,Ayaydın Mürtezaoğlu Sevil,PEHLİVANLAR KÜÇÜK Mehtap Spurious Hypoxemia in an Intensive Care Patient with Hyperleukocytosis Secondary to Acute Leukem. , 2021, ss.143 - 147. 10.5505/respircase.2021.57689
AMA HEKİMOĞLU M,Ayaydın Mürtezaoğlu S,PEHLİVANLAR KÜÇÜK M Spurious Hypoxemia in an Intensive Care Patient with Hyperleukocytosis Secondary to Acute Leukem. . 2021; 143 - 147. 10.5505/respircase.2021.57689
Vancouver HEKİMOĞLU M,Ayaydın Mürtezaoğlu S,PEHLİVANLAR KÜÇÜK M Spurious Hypoxemia in an Intensive Care Patient with Hyperleukocytosis Secondary to Acute Leukem. . 2021; 143 - 147. 10.5505/respircase.2021.57689
IEEE HEKİMOĞLU M,Ayaydın Mürtezaoğlu S,PEHLİVANLAR KÜÇÜK M "Spurious Hypoxemia in an Intensive Care Patient with Hyperleukocytosis Secondary to Acute Leukem." , ss.143 - 147, 2021. 10.5505/respircase.2021.57689
ISNAD HEKİMOĞLU, Muhammet Faruk vd. "Spurious Hypoxemia in an Intensive Care Patient with Hyperleukocytosis Secondary to Acute Leukem". (2021), 143-147. https://doi.org/10.5505/respircase.2021.57689
APA HEKİMOĞLU M, Ayaydın Mürtezaoğlu S, PEHLİVANLAR KÜÇÜK M (2021). Spurious Hypoxemia in an Intensive Care Patient with Hyperleukocytosis Secondary to Acute Leukem. Respiratory Case Reports, 10(2), 143 - 147. 10.5505/respircase.2021.57689
Chicago HEKİMOĞLU Muhammet Faruk,Ayaydın Mürtezaoğlu Sevil,PEHLİVANLAR KÜÇÜK Mehtap Spurious Hypoxemia in an Intensive Care Patient with Hyperleukocytosis Secondary to Acute Leukem. Respiratory Case Reports 10, no.2 (2021): 143 - 147. 10.5505/respircase.2021.57689
MLA HEKİMOĞLU Muhammet Faruk,Ayaydın Mürtezaoğlu Sevil,PEHLİVANLAR KÜÇÜK Mehtap Spurious Hypoxemia in an Intensive Care Patient with Hyperleukocytosis Secondary to Acute Leukem. Respiratory Case Reports, vol.10, no.2, 2021, ss.143 - 147. 10.5505/respircase.2021.57689
AMA HEKİMOĞLU M,Ayaydın Mürtezaoğlu S,PEHLİVANLAR KÜÇÜK M Spurious Hypoxemia in an Intensive Care Patient with Hyperleukocytosis Secondary to Acute Leukem. Respiratory Case Reports. 2021; 10(2): 143 - 147. 10.5505/respircase.2021.57689
Vancouver HEKİMOĞLU M,Ayaydın Mürtezaoğlu S,PEHLİVANLAR KÜÇÜK M Spurious Hypoxemia in an Intensive Care Patient with Hyperleukocytosis Secondary to Acute Leukem. Respiratory Case Reports. 2021; 10(2): 143 - 147. 10.5505/respircase.2021.57689
IEEE HEKİMOĞLU M,Ayaydın Mürtezaoğlu S,PEHLİVANLAR KÜÇÜK M "Spurious Hypoxemia in an Intensive Care Patient with Hyperleukocytosis Secondary to Acute Leukem." Respiratory Case Reports, 10, ss.143 - 147, 2021. 10.5505/respircase.2021.57689
ISNAD HEKİMOĞLU, Muhammet Faruk vd. "Spurious Hypoxemia in an Intensive Care Patient with Hyperleukocytosis Secondary to Acute Leukem". Respiratory Case Reports 10/2 (2021), 143-147. https://doi.org/10.5505/respircase.2021.57689