Yıl: 2021 Cilt: 30 Sayı: 2 Sayfa Aralığı: 173 - 181 Metin Dili: İngilizce DOI: 10.37845/ret.vit.2021.30.30 İndeks Tarihi: 18-05-2022

Evaluation of Retinal Vessel Diameter Measurement in Coronary Artery Disease

Öz:
Purpose: To examine the relationship between the stage of coronary artery disease (CAD) and retinal vessel diameters in patients with s table angina pectoris (SAP) and diagnosed with CAD. Material and Methods: Patients with a diagnosis of CAD are divided into 3 stages according to the results of coronary angiography. Stage 1) Normal coronary artery; stage 2) Non-critical narrowing of coronary arteries (<70% stenosis); stage 3) 70% and above critica l narrowing in coronary arteries. The diameters of retinal vascular structures were measured by Optical Coherence Tomography. The relationship between retinal arteriole, venule diameters and arterio-venous ratio (AVR) with CAD stage was evaluated. Results: One hundred six eyes of 106 CAD patients (36 patients in stage 1, 40 patients in stage 2, and 30 patients in stage 3) were stud ied (P = 0.539). Demographic characteristics of the groups were similar (P> 0.05). In stage 1, the mean diameter of the retinal arteri oles was 119.77 ± 7.24, and the venules were 142.44 ± 7.10; 118.77 ± 6.69 um and 143.01 ± 6.67 in stage 2, 104.60 ± 5.17 and 144.73 ± 12.45 um in stage 3, respectively. There was a significant difference between stage 1-3 and stage 2-3 (P = 0.730; P <0.001; P <0.001, respectively). There was no significant difference in venule diameter between the groups (P>0.05). The mean AVR was 0.84 ± 0.04 in stage 1, 0.83 ± 0.02 in stage 2, 0.72 ± 0.01 in stage 3, and there was a signi ficant difference between stage 1-3 and stage 2-3 (P = 0.301; P<0.001; P <0.001, respectively). It was found that there was a negative and signi ficant correlation between arteriolar diameter and AVR with CAD stage (r = -0.665, P <0.001, r = -0.717, P <0.001, respectively). Conclusions: It was found that as the CAD stage increased, there was a significant decrease in arteriole diameter and AVR value and a tendency to increase in venule diameter.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Bibliyografik
  • 1. Álvarez-Álvarez MM, Zanetti D, Carreras-Torres R, et al. A survey of sub-Saharan gene flow into the Mediterranean at risk loci for coronary artery disease. Eur J Hum Genet. 2017;25:472-6.
  • 2. Flammer J, Konieczka K, Bruno RM, et al. The eye and the heart. Eur Heart J. 2013;34:1270-8.
  • 3. Hogan MJ, Feeney L. THE ULTRASTRUCTURE OF THE RETINAL VESSELS. II. THE SMALL VESSELS. J Ultrastruct Res. 1963;49:29-46.
  • 4. Wang JJ, Taylor B, Wong TY, et al. Retinal vessel diameters and obesity: a population-based study in older persons. Obesity (Silver Spring). 2006;14:206-14.
  • 5. Roy MS, Klein R, Janal MN. Relationship of retinal vessel caliber to cardiovascular disease and mortality in African Americans with type 1 diabetes mellitus. Arch Ophthalmol. 2012;130:561-7.
  • 6. Leung H, Wang JJ, Rochtchina E, et al. Relationships between age, blood pressure, and retinal vessel diameters in an older population. Invest Ophthalmol Vis Sci. 2003;44:2900-4.
  • 7. Tedeschi-Reiner E, Strozzi M, Skoric B, et al. Relation of atherosclerotic changes in retinal arteries to the extent of coronary artery disease. Am J Cardiol. 2005;96:1107-9.
  • 8. Wong TY, Cheung N, Islam FM, et al. Relation of retinopathy to coronary artery calci fication: the multi-ethnic study of atherosclerosis. Am J Epidemiol. 2008;167:51-8.
  • 9. Wojtkowski M, Bajraszewski T, Gorczyńska I, et al. Ophthalmic imaging by spectral optical coherence tomography. Am J Ophthalmol. 2004;138:412-9.
  • 10. Fabritius T, Makita S, Hong Y, Myllyla R, Yasuno Y. Automated retinal shadow compensation of optical coherence tomography images. J Biomed Opt. 2009;14:010503.
  • 11. Fondi K, Aschinger GC, Bata AM, et al. Measurement of Retinal Vascular Caliber From Optical Coherence Tomography Phase Images. Invest Ophthalmol Vis Sci. 2016;57:Oct121-9.
  • 12. Miller RG, Prince CT, Klein R, et al. Retinal vessel diameter and the incidence of coronary artery disease in type 1 diabetes. Am J Ophthalmol. 2009;147:653-60.
  • 13. Kromer R, Tigges E, Rashed N, et al. Association between optical coherence tomography based retinal microvasculature characteristics and myocardial infarction in young men. Sci Rep. 2018;8:5615.
  • 14. Task Force Members, Montalescot G, Sechtem U, et al. 2013 ESC guidelines on the management of stable coronary artery disease: the Task Force on the management of stable coronary artery disease of the European Society of Cardiology [published correction appears in Eur Heart J. 2014 Sep 1;35(33):2260- 1]. Eur Heart J. 2013;34:2949-3003.
  • 15. Wilson, PW, et. al. Prediction of Coronary Heart Disease Using Risk Factor Categories. Circulation 1998 97: 1837-47
  • 16. Goldenberg D, Shahar J, Loewenstein A, Goldstein M Diameters of retinal blood vessels in a healthy cohort as measured by spectral domain optical coherence tomography. Retina, 2013;33:1888-94
  • 17. Terai N, Haustein M, Siegel A, Stodtmeister R, Pillunat LE, Sandner D Diameter of retinal vessels in patients with diabetic macular edema is not altered by intravitreal ranibizumab (lucentis). Retina, 2014; 34:1466-72
  • 18. Jiang Y, Li XY, Hu N, Huang ZJ, Wu F. Zhonghua Yu Fang Yi Xue Za Zhi. 2010;44:293-7
  • 19. Halcox JP, Schenke WH, Zalos G, et al. Prognostic value of coronary vascular endothelial dysfunction. Circulation. 2002;106:653-8.
  • 20. Wong TY, Islam FM, Klein R, et al. Retinal vascular caliber, cardiovascular risk factors, and in flammation: the multi-ethnic study of atherosclerosis (MESA). Invest Ophthalmol Vis Sci . 2006;47:2341-50.
  • 21. Huang Kezhen, L. I. et al. Correlation between coronary artery and fundus atherosclerosis. Journal of Clinical Medicine 20, 137-9 (2005).
  • 22. Parr JC, Spears GF. Mathematic relationships between the width of a retinal artery and the widths of its branches. Am J Ophthalmol. 1974;77:478-83.
  • 23. Sun C, Wang JJ, Mackey DA, Wong TY. Retinal vascular caliber: systemic, environmental, and genetic associations. Surv Ophthalmol. 2009;54:74-95.
  • 24. Xianliang, W., Jingyuan, M. & Henghe, W. Progress in Cardiac Syndrome and Related Cytokines. Chinese Journal of Cardiovascular Disease Research. 2007;5:372-4.
  • 25. Kaski JC, Elliott PM, Salomone O, et al. Concentration of circulating plasma endothelin in patients with angina and normal coronary angiograms. Br Heart J. 1995;74:620-4.
  • 26. Ye XD, Laties AM, Stone RA. Peptidergic innervation of the retinal vasculature and optic nerve head. Invest Ophthalmol Vis Sci. 1990;31:1731-7.
  • 27. Ross R. Atherosclerosis--an in flammatory disease. N Engl J Med. 1999;340:115-26.
  • 28. Klein R, Klein BE, Knudtson MD, Wong TY, Tsai MY. Are inflammatory factors related to retinal vessel caliber? The Beaver Dam Eye Study. Arch Ophthalmol. 2006;124:87-94.
  • 29. Ikram MK, de Jong FJ, Vingerling JR, et al. Are retinal arteriolar or venular diameters associated with markers for cardiovascular disorders? The Rotterdam Study. Invest Ophthalmol Vis Sci . 2004;45:2129-34
  • 30. Wong TY, Klein R, Couper DJ, et al. Retinal microvascular abnormalities and incident stroke: the Atherosclerosis Risk in Communities Study. Lancet. 2001;358(9288):1134-1140.
APA ÖZSAYGILI C, YILDIRIM Y, Kelesoglu S (2021). Evaluation of Retinal Vessel Diameter Measurement in Coronary Artery Disease. , 173 - 181. 10.37845/ret.vit.2021.30.30
Chicago ÖZSAYGILI CEMAL,YILDIRIM Yener,Kelesoglu Saban Evaluation of Retinal Vessel Diameter Measurement in Coronary Artery Disease. (2021): 173 - 181. 10.37845/ret.vit.2021.30.30
MLA ÖZSAYGILI CEMAL,YILDIRIM Yener,Kelesoglu Saban Evaluation of Retinal Vessel Diameter Measurement in Coronary Artery Disease. , 2021, ss.173 - 181. 10.37845/ret.vit.2021.30.30
AMA ÖZSAYGILI C,YILDIRIM Y,Kelesoglu S Evaluation of Retinal Vessel Diameter Measurement in Coronary Artery Disease. . 2021; 173 - 181. 10.37845/ret.vit.2021.30.30
Vancouver ÖZSAYGILI C,YILDIRIM Y,Kelesoglu S Evaluation of Retinal Vessel Diameter Measurement in Coronary Artery Disease. . 2021; 173 - 181. 10.37845/ret.vit.2021.30.30
IEEE ÖZSAYGILI C,YILDIRIM Y,Kelesoglu S "Evaluation of Retinal Vessel Diameter Measurement in Coronary Artery Disease." , ss.173 - 181, 2021. 10.37845/ret.vit.2021.30.30
ISNAD ÖZSAYGILI, CEMAL vd. "Evaluation of Retinal Vessel Diameter Measurement in Coronary Artery Disease". (2021), 173-181. https://doi.org/10.37845/ret.vit.2021.30.30
APA ÖZSAYGILI C, YILDIRIM Y, Kelesoglu S (2021). Evaluation of Retinal Vessel Diameter Measurement in Coronary Artery Disease. Retina-Vitreus, 30(2), 173 - 181. 10.37845/ret.vit.2021.30.30
Chicago ÖZSAYGILI CEMAL,YILDIRIM Yener,Kelesoglu Saban Evaluation of Retinal Vessel Diameter Measurement in Coronary Artery Disease. Retina-Vitreus 30, no.2 (2021): 173 - 181. 10.37845/ret.vit.2021.30.30
MLA ÖZSAYGILI CEMAL,YILDIRIM Yener,Kelesoglu Saban Evaluation of Retinal Vessel Diameter Measurement in Coronary Artery Disease. Retina-Vitreus, vol.30, no.2, 2021, ss.173 - 181. 10.37845/ret.vit.2021.30.30
AMA ÖZSAYGILI C,YILDIRIM Y,Kelesoglu S Evaluation of Retinal Vessel Diameter Measurement in Coronary Artery Disease. Retina-Vitreus. 2021; 30(2): 173 - 181. 10.37845/ret.vit.2021.30.30
Vancouver ÖZSAYGILI C,YILDIRIM Y,Kelesoglu S Evaluation of Retinal Vessel Diameter Measurement in Coronary Artery Disease. Retina-Vitreus. 2021; 30(2): 173 - 181. 10.37845/ret.vit.2021.30.30
IEEE ÖZSAYGILI C,YILDIRIM Y,Kelesoglu S "Evaluation of Retinal Vessel Diameter Measurement in Coronary Artery Disease." Retina-Vitreus, 30, ss.173 - 181, 2021. 10.37845/ret.vit.2021.30.30
ISNAD ÖZSAYGILI, CEMAL vd. "Evaluation of Retinal Vessel Diameter Measurement in Coronary Artery Disease". Retina-Vitreus 30/2 (2021), 173-181. https://doi.org/10.37845/ret.vit.2021.30.30