TY  - JOUR
TI  - Characteristics of Newly Diagnosed Hepatocellular Carcinoma Patients Across Turkey: Prospective Multicenter Observational 3K Registry Study
AB  - Aims: To evaluate patient profile for epidemiological and clinicopathological characteristics and potential risk/prognostic factors in newly diagnosed hepatocellular carcinoma (HCC) patients across Turkey. Methods: A total of 547 patients (mean (SD) age 62.6 (10.3) years, 81.9% were males) were included in this registry study. Data on patient characteristics, etiologies of HCC, laboratory values, and tumor characteristics and stages were recorded at study enrollment. Results: HBV infection (68.2%) was the leading etiology, followed by HCV infection (17.2%), HDV infection (5.5%), alcohol (6.4%), and NAFLD (3.5%), as the major etiologies. Considering that 51.6% of the patients had >5 cm HCC, 44% were Child–Pugh B/C and 57% were BCLC B-D, it appears that a significant group of HCC patients were diagnosed at advanced stages. Of 540 patients, 271 (50.2%) were referred or applied with the diagnosis of HCC. Patients with HCC at presentation had larger tumor size (median (min-max) 6.6 (0-30) vs. 4.8 (0-90) cm, P < .001) and more advanced BCLC stage (Stage C-D in 40.8% vs. 26.4%, respectively, P = .005), compared to patients who were diagnosed during follow-up. Conclusions: Our findings revealed that HBV infection was the leading etiology and a moderate-to-advanced disease was evident in more than half of patients at the time of diagnosis. HCC patients diagnosed at follow-up had smaller tumor size and earlier BCLC stage.
AU  - Alkim, Canan
AU  - Akarca, Ulus Salih
AU  - Akbulut, Hakan
AU  - Tekin, Salim Basol
AU  - Dilber, Feyza
AU  - Ozenirler, Seren
AU  - Yucel, Idris
AU  - IDİLMAN, Ramazan
AU  - Sonsuz, Abdullah
AU  - Ozyilkan, Ozgur
AU  - Akdogan, Meral
AU  - Ünsal, Belkıs
AU  - Dincer, Dinc
AU  - Gönen, Can
AU  - Cevik, Zeynep Merve
AU  - Yalçın, Kendal
AU  - Sezgin, Orhan
DO  - 10.5152/tjg.2021.201171
PY  - 2021
JO  - Turkish Journal of Gastroenterology
VL  - 32
IS  - 12
SN  - 1300-4948
SP  - 1019
EP  - 1028
DB  - TRDizin
UR  - http://search/yayin/detay/506348
ER  -