TY  - JOUR
TI  - Mucormycosis in a pediatric population: a review of 20cases from southern Turkey
AB  - Background. Mucormycosis is a fatal invasive fungal infection seen most often in patients with compromiseddefense mechanisms. The aim of this article was to review the data of pediatric mucor in the South of Turkey. Methods. Twenty pediatric cases with biopsy proven mucormycosis were reported, between January 2007through January 2017. Data were extracted from the medical charts of patients retrospectively.Results. Underlying conditions were hematological malignancy (75%), in whom 93% had acute leukemia,aplastic anemia (15%), diabetes mellitus (5%) and other malignancies (5%). The main sites of infection weresinus (85%); alone (29.4%) or with cerebral (17.6%), and orbital involvement (17.6%). Pulmonary involvementwas reported in 11 patients (55%), two of them had the alone form and nine cases were associated with nasalsinus involvement. Disseminated mucormycosis was documented in 45%. Fever and pain/swelling of organswere the most commonly encountered signs and symptoms. Treatment compromised of am-photericin Bmonotherapy in five patients. All patients except one received liposomal formu-lations (LAmB). A combinationof surgery and antifungal therapy was performed in 75%. Crude survival was 55%; among 15 cases treated witha combination of surgery and antifun-gal therapy, survival rate was 8/15 (53%). The overall mortality rate washigh in patients diagnosed with disseminated infection (100%). Conclusions. Mucormycosis in pediatric cases requires a high index of suspicion and urgent evaluation ofclinical samples. Surgical debridement should be considered when feasible. Initial medical therapy shouldinclude an amphotericin preparation with or step-down to posaconazole
AU  - OZDEMIR, SULEYMAN
AU  - Bayram, İbrahim
AU  - Alabaz, Derya
AU  - UGUZ, AYSUN HATICE
AU  - sonmez, gulsum
AU  - Sasmaz, Hatice Ilgen
DO  - 10.24953/turkjped.2021.01.002
PY  - 2021
JO  - Turkish Journal of Pediatrics
VL  - 63
IS  - 1
SN  - 0041-4301
SP  - 11
EP  - 22
DB  - TRDizin
UR  - http://search/yayin/detay/506764
ER  -