Association Between Prostate Biopsy Results and Serum Vitamin D Levels

AFERİN, Uğur; SIMSEKOGLU, MUHAMMED FATIH; Demirdag, Cetin; ÖZMAN, Oktay; Turegun, Fethi Ahmet

doi:10.4274/uob.galenos.2020.1695

Association Between Prostate Biopsy Results and Serum Vitamin D Levels

Oktay ÖZMAN, (Türkiye Sağlık Bilimleri Üniversitesi, Gaziosmanpaşa Eğitim ve Araştırma Hastanesi, İstanbul, Türkiye)

Fethi Ahmet TÜREGÜN, (Güney Hastanesi, Üroloji Kliniği, İstanbul, Türkiye)

Fatih ŞİMŞEKOĞLU, (İstanbul Üniversitesi-Cerrahpaşa, Cerrahpaşa Tıp Fakültesi, Üroloji Anabilim Dalı, İstanbul, Türkiye)

Uğur AFERİN, (İstanbul Üniversitesi-Cerrahpaşa, Cerrahpaşa Tıp Fakültesi, Üroloji Anabilim Dalı, İstanbul, Türkiye)

Çetin DEMIRDAG (İstanbul Üniversitesi-Cerrahpaşa, Cerrahpaşa Tıp Fakültesi, Üroloji Anabilim Dalı, İstanbul, Türkiye)

Üroonkoloji Bülteni

3 2

Yıl: 2021 Cilt: 20 Sayı: 2 Sayfa Aralığı: 83 - 86 Metin Dili: İngilizce DOI: 10.4274/uob.galenos.2020.1695 İndeks Tarihi: 21-05-2022

Association Between Prostate Biopsy Results and Serum Vitamin D Levels

Öz:

Objective: This study investigates the relationship between pathological findings of prostate biopsy and serum 25 (OH) D levels. Materials and Methods: Demographic, clinical and pathological data of 147 eligible patients were included in the study. All patients underwent transrectal ultrasound-guided prostate biopsy. Patients were divided into two groups; those with biopsy-proven prostate cancer (group 1) and those with only benign pathological findings (group 2). Later, two subgroups were formed among the patients diagnosed with prostate cancer (group 1); patients with serum 25 (OH) D levels above and below 20 ng/mL. All groups and subgroups were compared regarding clinical and pathological parameters. Finally, patients were divided according to International Society of Urological Pathology (ISUP) grade groups. Results: Serum 25 (OH) D level of patients with prostate cancer (group 1: 15.6±7.0 ng/mL) was slightly lower than the non-cancer group (group 2: 16.0±9.2 ng/mL) (p=0.38). On analysis of variance, there was a statistically significant difference between ISUP grade 1, grade 2-3 and grade 4-5 (p=0.012). Patients with clinically insignificant prostate cancer (ISUP grade 1) had significantly higher serum 25 (OH) D levels than other prostate cancer patients (p=0.023). There was a weak negative correlation between serum 25 (OH) D levels and ISUP grades (r=-0.319, p=0.01). Conclusion: There was no association between the diagnosis of prostate cancer and vitamin D deficiency. However, promising results have been obtained in favour of prostate cancer aggressiveness in vitamin D deficiency.

Anahtar Kelime:

Prostat Biyopsi Sonuçları ile Serum Arasındaki İlişki D Vitamini Düzeyleri

Öz:

Amaç: Bu çalışma prostat biyopsisinin patolojik bulguları ile serum 25 (OH) D düzeyleri arasındaki ilişkiyi araştırmaktadır. Gereç ve Yöntem: 147 uygun hastanın demografik, klinik ve patolojik verileri çalışmaya dahil edildi. Tüm hastalara transrektal ultrason eşliğinde prostat biyopsisi. Hastalar iki gruba ayrıldı; biyopsi ile kanıtlanmış prostat kanseri olanlar (grup 1) ve sadece iyi huylu olanlar patolojik bulgular (grup 2). Daha sonra prostat kanseri tanısı konulan hastalar arasında iki alt grup oluşturuldu (grup 1); serum 25 (OH) D olan hastalar 20 ng/mL'nin üzerindeki ve altındaki seviyeler. Tüm gruplar ve alt gruplar klinik ve patolojik parametreler açısından karşılaştırıldı. Son olarak, hastalar göre ayrıldı Uluslararası Ürolojik Patoloji Derneği (ISUP) dereceli gruplara. Bulgular: Prostat kanserli hastaların (grup 1: 15.6±7.0 ng/mL) serum 25 (OH) D düzeyi kanser olmayan gruba (grup 2: 16.0±9.2) göre biraz daha düşüktü. ng/mL) (p=0.38). Varyans analizinde ISUP derece 1, derece 2-3 ve derece 4-5 arasında istatistiksel olarak anlamlı bir fark vardı (p=0.012). olan hastalar klinik olarak önemsiz prostat kanseri (ISUP derece 1), diğer prostat kanseri hastalarına göre anlamlı olarak daha yüksek serum 25 (OH) D seviyelerine sahipti (p=0.023). vardı serum 25 (OH) D seviyeleri ile ISUP dereceleri arasında zayıf negatif korelasyon (r=-0.319, p=0.01). Sonuç: Prostat kanseri tanısı ile D vitamini eksikliği arasında ilişki bulunamadı. Ancak, lehte umut verici sonuçlar elde edildi D vitamini eksikliğinde prostat kanseri saldırganlığının değerlendirilmesi.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ÖZMAN O, Turegun F, SIMSEKOGLU M, AFERİN U, Demirdag C (2021). Association Between Prostate Biopsy Results and Serum Vitamin D Levels. , 83 - 86. 10.4274/uob.galenos.2020.1695
Chicago	ÖZMAN Oktay,Turegun Fethi Ahmet,SIMSEKOGLU MUHAMMED FATIH,AFERİN Uğur,Demirdag Cetin Association Between Prostate Biopsy Results and Serum Vitamin D Levels. (2021): 83 - 86. 10.4274/uob.galenos.2020.1695
MLA	ÖZMAN Oktay,Turegun Fethi Ahmet,SIMSEKOGLU MUHAMMED FATIH,AFERİN Uğur,Demirdag Cetin Association Between Prostate Biopsy Results and Serum Vitamin D Levels. , 2021, ss.83 - 86. 10.4274/uob.galenos.2020.1695
AMA	ÖZMAN O,Turegun F,SIMSEKOGLU M,AFERİN U,Demirdag C Association Between Prostate Biopsy Results and Serum Vitamin D Levels. . 2021; 83 - 86. 10.4274/uob.galenos.2020.1695
Vancouver	ÖZMAN O,Turegun F,SIMSEKOGLU M,AFERİN U,Demirdag C Association Between Prostate Biopsy Results and Serum Vitamin D Levels. . 2021; 83 - 86. 10.4274/uob.galenos.2020.1695
IEEE	ÖZMAN O,Turegun F,SIMSEKOGLU M,AFERİN U,Demirdag C "Association Between Prostate Biopsy Results and Serum Vitamin D Levels." , ss.83 - 86, 2021. 10.4274/uob.galenos.2020.1695
ISNAD	ÖZMAN, Oktay vd. "Association Between Prostate Biopsy Results and Serum Vitamin D Levels". (2021), 83-86. https://doi.org/10.4274/uob.galenos.2020.1695

APA	ÖZMAN O, Turegun F, SIMSEKOGLU M, AFERİN U, Demirdag C (2021). Association Between Prostate Biopsy Results and Serum Vitamin D Levels. Üroonkoloji Bülteni, 20(2), 83 - 86. 10.4274/uob.galenos.2020.1695
Chicago	ÖZMAN Oktay,Turegun Fethi Ahmet,SIMSEKOGLU MUHAMMED FATIH,AFERİN Uğur,Demirdag Cetin Association Between Prostate Biopsy Results and Serum Vitamin D Levels. Üroonkoloji Bülteni 20, no.2 (2021): 83 - 86. 10.4274/uob.galenos.2020.1695
MLA	ÖZMAN Oktay,Turegun Fethi Ahmet,SIMSEKOGLU MUHAMMED FATIH,AFERİN Uğur,Demirdag Cetin Association Between Prostate Biopsy Results and Serum Vitamin D Levels. Üroonkoloji Bülteni, vol.20, no.2, 2021, ss.83 - 86. 10.4274/uob.galenos.2020.1695
AMA	ÖZMAN O,Turegun F,SIMSEKOGLU M,AFERİN U,Demirdag C Association Between Prostate Biopsy Results and Serum Vitamin D Levels. Üroonkoloji Bülteni. 2021; 20(2): 83 - 86. 10.4274/uob.galenos.2020.1695
Vancouver	ÖZMAN O,Turegun F,SIMSEKOGLU M,AFERİN U,Demirdag C Association Between Prostate Biopsy Results and Serum Vitamin D Levels. Üroonkoloji Bülteni. 2021; 20(2): 83 - 86. 10.4274/uob.galenos.2020.1695
IEEE	ÖZMAN O,Turegun F,SIMSEKOGLU M,AFERİN U,Demirdag C "Association Between Prostate Biopsy Results and Serum Vitamin D Levels." Üroonkoloji Bülteni, 20, ss.83 - 86, 2021. 10.4274/uob.galenos.2020.1695
ISNAD	ÖZMAN, Oktay vd. "Association Between Prostate Biopsy Results and Serum Vitamin D Levels". Üroonkoloji Bülteni 20/2 (2021), 83-86. https://doi.org/10.4274/uob.galenos.2020.1695