Treatment of open wounds secondary to trauma using polyurethane foams with boric acid particles

Ciloglu, Osman; Külahcı, Özgür; Yörükoğlu, Abdulkerim; oğur, hasan ulaş; Tekbaş, Volkan Tolga; KAPUKAYA, RANA

doi:10.14744/tjtes.2020.38613

Treatment of open wounds secondary to trauma using polyurethane foams with boric acid particles

Hasan Ulaş Oğur, (Adana Şehir Eğitim ve Araştırma Hastanesi, Ortopedi ve Travmatoloji Anabilim Dalı, Adana, Türkiye)

Rana Kapukaya, (Adana Şehir Eğitim ve Araştırma Hastanesi, Plastik ve Rekonstrüktif Cerrahi Anabilim Dalı, Adana, Türkiye)

Osman ÇİLOĞLU, (Adana Şehir Eğitim ve Araştırma Hastanesi, Ortopedi ve Travmatoloji Anabilim Dalı, Adana, Türkiye)

Özgür KÜLAHÇI, (Adana Şehir Eğitim ve Araştırma Hastanesi, Tıbbi Patoloji Anabilim Dalı, Adana, Türkiye)

Volkan Tolga Tekbaş, (Adana Şehir Eğitim ve Araştırma Hastanesi, Ortopedi ve Travmatoloji Anabilim Dalı, Adana, Türkiye)

Abdülkerim YÖRÜKOĞLU (Ulusal Bor Enstitüsü, Ankara, Türkiye)

Ulusal Travma ve Acil Cerrahi Dergisi

8 2

Yıl: 2021 Cilt: 27 Sayı: 6 Sayfa Aralığı: 624 - 630 Metin Dili: İngilizce DOI: 10.14744/tjtes.2020.38613 İndeks Tarihi: 21-05-2022

Treatment of open wounds secondary to trauma using polyurethane foams with boric acid particles

Öz:

BACKGROUND: To investigate the efficacy of new foams with boric acid particles combined with a negative pressure wound treatment (NPWT) system in open fractures with tissue defects secondary to trauma. METHODS: Forty-nine patients with open fractures secondary to trauma with soft tissue defects who were admitted between 2016 and 2018 were included in the study. Patients were examined in two groups. In Group 1, boric acid-impregnated foams combined with the NPWT system were used in 27 patients, and in Group 2, silver nitrate-impregnated foams combined with NPWT systems were used in 22 patients. In addition to evaluating the broad-spectrum antibacterial feature of silver nitrate, the antimicrobial, angiogenetic, and epithelializing effects of boric acid were investigated macroscopically and histopathologically. RESULTS: A reduction in wound size and granulation was observed in each group. Macroscopically, the reduction in wound size, epithelialization and granulation were pronounced in Group 1 and in Group 2. Microscopically, the number of fibroblasts, collagen synthesis, and angiogenesis were significantly increased in Group 1 compared with Group 2. CONCLUSION: In this clinical trial, both the broad spectrum antimicrobial feature of boric acid and its positive effect on the cells responsible for wound healing were found to be an alternative compared with silver nitrate. The use of new foams with boric acid particles combined with the NPWT system may be a good alternative method in the treatment of open wounds due to trauma.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Huang C, Leavitt T, Bayer LR, Orgil DP. Effect of negative pressure wound therapy on wound healing. Currn Probl Surg 2014;51:301–31.
2. Putnis S, Khan WS, Wong JML. Negative pressure wound therapy-a review of its uses in orthopaedic trauma. Open Orthop J 2014;8:142–7.
3. Orgill DP, Manders EK, Sumpio BE, Lee RC, Attinger CE, Gurtner GC, et al. The mechanisms of action of vacuum assisted closure: More to learn. Surgery 2009;146:40–51.
4. Gaisford S, Beezer AE, Bishop AH, Walker M, Parsons D. An in vitro method for the quantitative determination of the antimicrobial efficacy of silver-containing wound dressings. Int J Pharm 2009;336:111–6.
5. Sigel HJ, Herrera DF, Gay J. Silver negative pressure dressing with vacuum-assisted closure of massive pelvic and extremity wounds. Clin Orthop Relat Res 2014;472:830–5.
6. McDonnell G, Russell AD. Antiseptics and disinfectants: Activity, action, and resistance. Clin Microbiol Rev 1999;12:147–79.
7. Borrelly J, Blech M, Grosdidier G, Martin-Thomas C, Hartemann P. Contribution of a 3% solution of boric acid in the treatment of deep wounds with loss of substance. Ann Chir Plast Esthet 1991;36:65–9.
8. Tepedelen BE, Soya E, Korkmaz M. Boric acid reduces the formation of DNA double-strand breaks and accelerates wound healing process. Biol Trace Elem Res 2016;174:309–18.
9. Nzietchueng RM, Dousset B, Franck P, Benderdour M, Nabet P, Hess K. Mechanisms implicated in the effects of boron on wound healing. J Trace Elem Med Biol 2002;16:239–44.
10. Gupta A, Kumar P. Assessment of the histological state of the healing wound. Plast Aesthet Res 2015;2:239–42.
11. Scherer S, Pietramaggiori G, Mathews J, Prsa MJ, Huang S, Orgill DP. The mechanism of action of the vacuum assisted closure device. Plast Reconstr Surg 2008;122:786–97.
12. Ingber DE. The mechanochemical basis of cell and tissue regulation. Mech Chem Biosyst 2004;1:53–68.
13. Osterhoff G, Zwolak P, Kruger C, Wilzeck V, Simmen HP, Jukema GN. Risk factors for prolonged treatment and hospital readmission in 280 cases of negative-pressure wound therapy. J Plastic Reconstr Aesth Surg 2014;67:629–33.
14. Liu X, Zhang H, Cen S, Huang F. Negative pressure wound therapy versus conventional wound dressings in treatment of open fractures: A systematic review and meta-analysis. Int J Surg 2018;53:72–9.
15. Sudmann E, Vik H, Rait M, Todnem K, Andersen KJ, Julsham K, et al. Systemic and local silver accumulation after total hip replacement using silver-impregnated bone cement. Med Prog Technol 1994;20:179–84.
16. Trop M. Silver-coated dressing acticoat caused raised liver enzymes and argyria-like symptoms in burn patient. J Trauma 2006;61:1024.
17. Chung IS, Lee MY, Shin DH, Jung HR. Three systemic argyria cases after ingestion of colloidal silver solution. Int J Dermatol 2010;49:1175–7.
18. Tomi NS, Kränke B, Aberer W. A silver man. Lancet 2004;363:532.
19. Hazelwood KJ. Exposure-related health effects of silver and silver compounds: A review. Ann Occup Hyg 2005;49:575–85.
20. Naghii MR Samman S. The role of boron in nutrition and metabolism. Prog Food Nutr Sci 1993;17:331–49.
21. Chebassier N, Ouijja EH, Viegas I, Dreno B. Stimulatory effect of boron and manganese salts on keratinocyte migration. Acta Derm Venereol 2004;84:191–4.
22. Dogan A, Demirci S, Caglayan AB, Kılıc¸ E, Günal MY, Uslu U, et al. Sodium pentaborate pentahydrate and pluronic containing hydrogel increases cutaneous wound healing in vitro and in vivo. Biol Trace Elem Res 2014;162:72–9.
23. Demirci S, Dogan A, Karakus E, Halıcı Z, Topcu A, Demirci E, et al. Boron and poloxamer (F68 and F127) containing hydrogel formulation for burn wound healing. Biol Trace Elem Res 2015;168:169–80.
24. Yılmaz MT. Minimum inhibitory and minimum bactericidal concentrations of boron compounds against several bacterial strains. Turk J Med Sci 2012;42:1423–9.
25. Kumara DU, Fernando SS, Kottahachchi J, Dissanayake DM, Athukorala GI, Chandrasiri NS, et al. Evaluation of bactericidal effect of three antiseptics on bacteria isolated from wounds. J Wound Care 2015;24:5–10.
26. Jacobs S, Simhaee DA, Marsano A, Fomovsky GM, Niedt G, Wu JK. Efficacy and mechanisms of vacuum-assisted closure (VAC) therapy in promoting wound healing: A rodent model. J Plast Reconstr Aesthet Surg 2009;62:1331–8.
27. Eginton MT, Brown KR, Seabrook GR, Towne JB, Cambria RA. A prospective randomized evaluation of negative-pressure wound dressings for diabetic foot wounds. Ann Vasc Surg 2003;17:645–9.
28. Yusuf E, Jordan X, Clauss M, Borens O, Mader M, Trampuz A. High bacterial load in negative pressure wound therapy (NPWT) foams used in the treatment of chronic wounds. Wound Repair Regen 2013;21:677–81.
29. Evans D, Land L. Topical negative pressure for treating chronic wounds: A systematic review. Br J Plast Surg 2001;54:238–42.
30. Demirci S, Doğan A, Aydın S Dülger EC Şahin F. Boron promotes streptozotocin-induced diabetic wound healing: Roles in cell proliferation and migration, growth factor expression, and inflammation. Mol Cell Biochem 2016;417:119–33.

APA	oğur h, KAPUKAYA R, Ciloglu O, Külahcı Ö, Tekbaş V, Yörükoğlu A (2021). Treatment of open wounds secondary to trauma using polyurethane foams with boric acid particles. , 624 - 630. 10.14744/tjtes.2020.38613
Chicago	oğur hasan ulaş,KAPUKAYA RANA,Ciloglu Osman,Külahcı Özgür,Tekbaş Volkan Tolga,Yörükoğlu Abdulkerim Treatment of open wounds secondary to trauma using polyurethane foams with boric acid particles. (2021): 624 - 630. 10.14744/tjtes.2020.38613
MLA	oğur hasan ulaş,KAPUKAYA RANA,Ciloglu Osman,Külahcı Özgür,Tekbaş Volkan Tolga,Yörükoğlu Abdulkerim Treatment of open wounds secondary to trauma using polyurethane foams with boric acid particles. , 2021, ss.624 - 630. 10.14744/tjtes.2020.38613
AMA	oğur h,KAPUKAYA R,Ciloglu O,Külahcı Ö,Tekbaş V,Yörükoğlu A Treatment of open wounds secondary to trauma using polyurethane foams with boric acid particles. . 2021; 624 - 630. 10.14744/tjtes.2020.38613
Vancouver	oğur h,KAPUKAYA R,Ciloglu O,Külahcı Ö,Tekbaş V,Yörükoğlu A Treatment of open wounds secondary to trauma using polyurethane foams with boric acid particles. . 2021; 624 - 630. 10.14744/tjtes.2020.38613
IEEE	oğur h,KAPUKAYA R,Ciloglu O,Külahcı Ö,Tekbaş V,Yörükoğlu A "Treatment of open wounds secondary to trauma using polyurethane foams with boric acid particles." , ss.624 - 630, 2021. 10.14744/tjtes.2020.38613
ISNAD	oğur, hasan ulaş vd. "Treatment of open wounds secondary to trauma using polyurethane foams with boric acid particles". (2021), 624-630. https://doi.org/10.14744/tjtes.2020.38613

APA	oğur h, KAPUKAYA R, Ciloglu O, Külahcı Ö, Tekbaş V, Yörükoğlu A (2021). Treatment of open wounds secondary to trauma using polyurethane foams with boric acid particles. Ulusal Travma ve Acil Cerrahi Dergisi, 27(6), 624 - 630. 10.14744/tjtes.2020.38613
Chicago	oğur hasan ulaş,KAPUKAYA RANA,Ciloglu Osman,Külahcı Özgür,Tekbaş Volkan Tolga,Yörükoğlu Abdulkerim Treatment of open wounds secondary to trauma using polyurethane foams with boric acid particles. Ulusal Travma ve Acil Cerrahi Dergisi 27, no.6 (2021): 624 - 630. 10.14744/tjtes.2020.38613
MLA	oğur hasan ulaş,KAPUKAYA RANA,Ciloglu Osman,Külahcı Özgür,Tekbaş Volkan Tolga,Yörükoğlu Abdulkerim Treatment of open wounds secondary to trauma using polyurethane foams with boric acid particles. Ulusal Travma ve Acil Cerrahi Dergisi, vol.27, no.6, 2021, ss.624 - 630. 10.14744/tjtes.2020.38613
AMA	oğur h,KAPUKAYA R,Ciloglu O,Külahcı Ö,Tekbaş V,Yörükoğlu A Treatment of open wounds secondary to trauma using polyurethane foams with boric acid particles. Ulusal Travma ve Acil Cerrahi Dergisi. 2021; 27(6): 624 - 630. 10.14744/tjtes.2020.38613
Vancouver	oğur h,KAPUKAYA R,Ciloglu O,Külahcı Ö,Tekbaş V,Yörükoğlu A Treatment of open wounds secondary to trauma using polyurethane foams with boric acid particles. Ulusal Travma ve Acil Cerrahi Dergisi. 2021; 27(6): 624 - 630. 10.14744/tjtes.2020.38613
IEEE	oğur h,KAPUKAYA R,Ciloglu O,Külahcı Ö,Tekbaş V,Yörükoğlu A "Treatment of open wounds secondary to trauma using polyurethane foams with boric acid particles." Ulusal Travma ve Acil Cerrahi Dergisi, 27, ss.624 - 630, 2021. 10.14744/tjtes.2020.38613
ISNAD	oğur, hasan ulaş vd. "Treatment of open wounds secondary to trauma using polyurethane foams with boric acid particles". Ulusal Travma ve Acil Cerrahi Dergisi 27/6 (2021), 624-630. https://doi.org/10.14744/tjtes.2020.38613