Assessment of Left Ventricular Function using a Two-Dimensional Speckle Tracking Echocardiography in Asymptomatic Survivors of Hodgkin’s Lymphoma in Long-Term Follow-Up

Karaca Özer, Pelin; Basar, Rafet; Oztop, Nida; Umman, Berrin; Altinkaynak, Mustafa; Nalcaci, Meliha; ATICI, Adem

doi:10.4274/imj.galenos.2021.07448

Assessment of Left Ventricular Function using a Two-Dimensional Speckle Tracking Echocardiography in Asymptomatic Survivors of Hodgkin’s Lymphoma in Long-Term Follow-Up

Mustafa ALTINKAYNAK, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, İstanbul, Türkiye)

Pelin KARACA ÖZER, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İstanbul, Türkiye)

Adem ATICI, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İstanbul, Türkiye)

Rafet BAŞAR, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, İstanbul, Türkiye)

Nida ÖZTOP, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, İstanbul, Türkiye)

Berrin UMMAN, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İstanbul, Türkiye)

Meliha NALÇACI (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Hematoloji Anabilim Dalı, İstanbul, Türkiye)

İstanbul Medical Journal

3 0

Yıl: 2021 Cilt: 22 Sayı: 4 Sayfa Aralığı: 300 - 305 Metin Dili: İngilizce DOI: 10.4274/imj.galenos.2021.07448 İndeks Tarihi: 22-05-2022

Assessment of Left Ventricular Function using a Two-Dimensional Speckle Tracking Echocardiography in Asymptomatic Survivors of Hodgkin’s Lymphoma in Long-Term Follow-Up

Öz:

Introduction: Two-dimensional speckle tracking echocardiography (2D-STE) is sensitive in the assessment of left ventricular (LV) systolic function and may aid in diagnosis of late cardiac effects in asymptomatic Hodgkin’s lymphoma (HL) survivors in long-term follow-up. Methods: This is a cross-sectional study of 21 HL survivors previously treated with anthracyclines, with (8/21) or withoutmediastinal (8/21) radiotherapy and no recurrence at least 3 years after treatment compared to age-matched 43 healthy volunteers. To assess long-term cardiac complications, we performed 12-lead electrocardiography and 2D transthoracic echocardiography. In addition to conventional echocardiographic parameters, we used tissue Doppler echocardiography for LV diastolic functions and 2D-STE for evaluating the global longitudinal strain (GLS) of the LV myocardium. Results: The mean age of the HL survivors was 40±15 years and the female sex was predominant (11/21). The average PR interval of the HL survivors was significantly longer (154.7±19.6 ms vs 133.8±13.9 ms, p<0.001) while the QTc interval was significantly shorter (383.8±18.7 ms vs 402.4±11.7 ms, p<0.001) than the control group. HL survivors had significantly impaired GLS compared to the control group (-19.3±2.6 vs -22.6±1.6, p<0.001). Thirteen of the HL survivors (61%) with normal LV ejection fraction had impaired GLS. The frequency of left ventricular diastolic dysfunction (LVDD) in the HL survivors group was significantly higher than that of the control group (52% vs 26%, p=0.015). Therefore, LVDD was detected in 61.5% of patients with a GLS <-20%. Conclusion: 2D-STE could be used in predicting late-onset subclinical cardiac side effects following treatment in asymptomatic HL survivors for long-term follow-up.

Anahtar Kelime:

Kür Sağlanan Hodgkin Lenfoma Hastalarının Uzun Dönem Takibinde Sol Ventrikül Fonksiyonlarının İki Boyutlu Strain Ekokardiyografi ile Değerlendirilmesi

Öz:

Amaç: İki boyutlu strain ekokardiyografi (2D-STE) sol ventrikül (SV) sistolik fonksiyonlarının ölçümünde hassas bir ölçüm yöntemidir. Hodgkin lenfoma (HL) hastalarının takibinde ortaya çıkabilecek geç kardiyak yan etkilerin değerlendirilmesinde kullanılabilir. Yöntemler: Bu çalışma antrasiklin (n=21) ± mediasten (8/21)/ mediasten dışı (8/21) ışın tedavisi alan, en az 3 yıl takipte nüks saptanmamış 21 HL hastası ve yaşları eşleştirilmiş 43 sağlıklı bireyin karşılaştırıldığı kesitsel çalışmadır. Bireylerin kardiyak komplikasyonları 12 derivasyonlu elektrokardiyografi ve konvansiyonel ekokardiyografi ile değerlendirildi. SV diyastolik fonksiyonu için doku Doppler ekokardiyografi, SV miyokardiyumun global longitudinal strain (GLS) değerlendirmesi için 2D-STE kullanıldı. Bulgular: HL hastalarının ortalama yaşı 40±15 saptandı ve çoğunlukla kadındı (11/21). HL hastalarında kontrol grubuna göre ortalama PR mesafesi anlamlı derecede artmış (154,7±19,6 ms vs 133,8±13,9 ms, p<0,001), QTc mesafesi azalmış (383,8±18,7 ms vs 402,4±11,7 ms, p<0,001) saptandı. HL hastalarında GLS değerleri kontrol grubuna göre anlamlı derece azalmış (-19,3±2,6 vs -22,6±1,6, p<0,001) saptandı. SV sistolik fonksiyonları normal olan 13 hastanın (%61,9) strain değerleri azalmış saptandı. Sol ventrikül diyastolik disfonksiyon (SVDD) sıklığı HL hastalarında kontrol grubuna göre anlamlı derecede yüksek saptandı (%52 vs %26, p=0,015). GLS’si azalmış saptanan 13 hastanın 8’inde (%61,5) SVDD saptandı. Sonuç: HL hastalarında geç başlangıçlı kardiyak yan etkilerin saptanmasında 2D-STE kullanılması önerilir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Altinkaynak M, Karaca Özer P, ATICI A, Basar R, Oztop N, Umman B, Nalcaci M (2021). Assessment of Left Ventricular Function using a Two-Dimensional Speckle Tracking Echocardiography in Asymptomatic Survivors of Hodgkin’s Lymphoma in Long-Term Follow-Up. , 300 - 305. 10.4274/imj.galenos.2021.07448
Chicago	Altinkaynak Mustafa,Karaca Özer Pelin,ATICI Adem,Basar Rafet,Oztop Nida,Umman Berrin,Nalcaci Meliha Assessment of Left Ventricular Function using a Two-Dimensional Speckle Tracking Echocardiography in Asymptomatic Survivors of Hodgkin’s Lymphoma in Long-Term Follow-Up. (2021): 300 - 305. 10.4274/imj.galenos.2021.07448
MLA	Altinkaynak Mustafa,Karaca Özer Pelin,ATICI Adem,Basar Rafet,Oztop Nida,Umman Berrin,Nalcaci Meliha Assessment of Left Ventricular Function using a Two-Dimensional Speckle Tracking Echocardiography in Asymptomatic Survivors of Hodgkin’s Lymphoma in Long-Term Follow-Up. , 2021, ss.300 - 305. 10.4274/imj.galenos.2021.07448
AMA	Altinkaynak M,Karaca Özer P,ATICI A,Basar R,Oztop N,Umman B,Nalcaci M Assessment of Left Ventricular Function using a Two-Dimensional Speckle Tracking Echocardiography in Asymptomatic Survivors of Hodgkin’s Lymphoma in Long-Term Follow-Up. . 2021; 300 - 305. 10.4274/imj.galenos.2021.07448
Vancouver	Altinkaynak M,Karaca Özer P,ATICI A,Basar R,Oztop N,Umman B,Nalcaci M Assessment of Left Ventricular Function using a Two-Dimensional Speckle Tracking Echocardiography in Asymptomatic Survivors of Hodgkin’s Lymphoma in Long-Term Follow-Up. . 2021; 300 - 305. 10.4274/imj.galenos.2021.07448
IEEE	Altinkaynak M,Karaca Özer P,ATICI A,Basar R,Oztop N,Umman B,Nalcaci M "Assessment of Left Ventricular Function using a Two-Dimensional Speckle Tracking Echocardiography in Asymptomatic Survivors of Hodgkin’s Lymphoma in Long-Term Follow-Up." , ss.300 - 305, 2021. 10.4274/imj.galenos.2021.07448
ISNAD	Altinkaynak, Mustafa vd. "Assessment of Left Ventricular Function using a Two-Dimensional Speckle Tracking Echocardiography in Asymptomatic Survivors of Hodgkin’s Lymphoma in Long-Term Follow-Up". (2021), 300-305. https://doi.org/10.4274/imj.galenos.2021.07448

APA	Altinkaynak M, Karaca Özer P, ATICI A, Basar R, Oztop N, Umman B, Nalcaci M (2021). Assessment of Left Ventricular Function using a Two-Dimensional Speckle Tracking Echocardiography in Asymptomatic Survivors of Hodgkin’s Lymphoma in Long-Term Follow-Up. İstanbul Medical Journal, 22(4), 300 - 305. 10.4274/imj.galenos.2021.07448
Chicago	Altinkaynak Mustafa,Karaca Özer Pelin,ATICI Adem,Basar Rafet,Oztop Nida,Umman Berrin,Nalcaci Meliha Assessment of Left Ventricular Function using a Two-Dimensional Speckle Tracking Echocardiography in Asymptomatic Survivors of Hodgkin’s Lymphoma in Long-Term Follow-Up. İstanbul Medical Journal 22, no.4 (2021): 300 - 305. 10.4274/imj.galenos.2021.07448
MLA	Altinkaynak Mustafa,Karaca Özer Pelin,ATICI Adem,Basar Rafet,Oztop Nida,Umman Berrin,Nalcaci Meliha Assessment of Left Ventricular Function using a Two-Dimensional Speckle Tracking Echocardiography in Asymptomatic Survivors of Hodgkin’s Lymphoma in Long-Term Follow-Up. İstanbul Medical Journal, vol.22, no.4, 2021, ss.300 - 305. 10.4274/imj.galenos.2021.07448
AMA	Altinkaynak M,Karaca Özer P,ATICI A,Basar R,Oztop N,Umman B,Nalcaci M Assessment of Left Ventricular Function using a Two-Dimensional Speckle Tracking Echocardiography in Asymptomatic Survivors of Hodgkin’s Lymphoma in Long-Term Follow-Up. İstanbul Medical Journal. 2021; 22(4): 300 - 305. 10.4274/imj.galenos.2021.07448
Vancouver	Altinkaynak M,Karaca Özer P,ATICI A,Basar R,Oztop N,Umman B,Nalcaci M Assessment of Left Ventricular Function using a Two-Dimensional Speckle Tracking Echocardiography in Asymptomatic Survivors of Hodgkin’s Lymphoma in Long-Term Follow-Up. İstanbul Medical Journal. 2021; 22(4): 300 - 305. 10.4274/imj.galenos.2021.07448
IEEE	Altinkaynak M,Karaca Özer P,ATICI A,Basar R,Oztop N,Umman B,Nalcaci M "Assessment of Left Ventricular Function using a Two-Dimensional Speckle Tracking Echocardiography in Asymptomatic Survivors of Hodgkin’s Lymphoma in Long-Term Follow-Up." İstanbul Medical Journal, 22, ss.300 - 305, 2021. 10.4274/imj.galenos.2021.07448
ISNAD	Altinkaynak, Mustafa vd. "Assessment of Left Ventricular Function using a Two-Dimensional Speckle Tracking Echocardiography in Asymptomatic Survivors of Hodgkin’s Lymphoma in Long-Term Follow-Up". İstanbul Medical Journal 22/4 (2021), 300-305. https://doi.org/10.4274/imj.galenos.2021.07448