TY  - JOUR
TI  - Effect of Mitomycin C in the prevention of tendon adhesion after surgery and the effect of biomechanical stretching on tendon histology
AB  - Objective: In this study, optimal dose to reduce tendon adhesion, by using the dose-dependent fibroblast proliferation inhibi- tion effect of Mit-C, and the level, which the tendon histologies are affected, using biomechanical stretching, is investigated. Methods: 56 chicken flexor tendons were used in this study. A total of 9 groups were formed. Mit-C were applied between the tendon and the sheath; 0.9% NaCl for surgical control groups (groupII, groupIII), 0.1mg/ml Mit-C (groupIV, groupVII), 0.2mg/ml Mit-C (groupV, groupVIII) 0.5 mg/ml Mit-C (groupVI, groupIX). Macroscopic, microscopic, synovial sheath thick- ness and active fibroblast count were compared between the groups that underwent biomechanical stretching (groups III,V,VII,IX) and groups without biomechanical stretching (groups I,II,IV,VI,VIII). Results: After the macroscopic and microscopic examination, it was observed that the groups with the most adhesion were surgical control groups. The best results from the experimental groups were seen in group VIII, but the results of the groups were similar. When active fibroblast count was examined, it was seen that group VIII had the least active fibroblast count. Conclusion: According to the results of the evaluation, Mit-C, by inhibiting fibroblast proliferation and decreasing synovial sheath thickness, decreased adhesion formation. At the same time, it was concluded that the optimal dose for adhesion prevention was 0.2mg/ml, biomechanical stretching affected tendon histology and the drug was suitable for clinical studi
AU  - yıldız, mehmet
AU  - BAKİ, Mehmet Emre
AU  - ABDİOĞLU, Ahmet Atilla
AU  - Güvercin, Yılmaz
AU  - KARAHASANOĞLU, İlker
AU  - KERİMOĞLU, Gökçen
DO  - 10.5455/handmicrosurg.69020
PY  - 2021
JO  - Hand and Microsurgery
VL  - 10
IS  - 3
SN  - 2458-7834
SP  - 193
EP  - 202
DB  - TRDizin
UR  - http://search/yayin/detay/507871
ER  -