Effects of low-density pulsed ultrasound treatment on transforming growth factor-beta, collagen level, histology, biomechanics, and function in repaired rat tendons
Yıl: 2021 Cilt: 67 Sayı: 2 Sayfa Aralığı: 167 - 174 Metin Dili: İngilizce DOI: 10.5606/tftrd.2021.5118 İndeks Tarihi: 23-05-2022
Effects of low-density pulsed ultrasound treatment on transforming growth factor-beta, collagen level, histology, biomechanics, and function in repaired rat tendons
Öz: Objectives: The aim of this study is to compare the effects of low-density pulsed ultrasound (LIPUS) treatment on growth factors/collagen production, histological, biomechanical, and function of rats with Achilles tendon injury. Materials and methods: A total of 44 Wistar Albino rats were used in the study between April 2017 and June 2018. The rats were randomized to two treatment groups. Group 1 (n=6) received LIPUS treatment (0.3 Watt/cm2; 1 MHz, 1:5 pulse mode) and Group 2 (n=6)received sham ultrasound (US) treatment following Achilles tendon surgery. Transforming growth factor-beta 1 (TGF-β1) and collagen gene expression levels were evaluated using polymerase chain reaction. The histological evaluation was performed with the Bonar scoring system. The tensile strength was measured by biomechanical testing and the function was evaluated with the Achilles Functional Index (AFI). Results: Although TGF-β1 expression and tensile strength evaluation showed a tendency to improve in favor of the LIPUS group, no statistically significant difference was found (p=0.065 and p=0.053, respectively). The COL3 gene expression in the LIPUS group and the COL1 expression in the sham US group were significantly higher. Bonar scores and AFI scores showed a statistically significant improvement in the LIPUS group, compared to the sham US group. Conclusion: Our study results show that LIPUS yields positive effects on tendon histology and functional status in repaired Achilles tendon in rats.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | İNCEOĞLU A, SAHIN F, AKKAYA N, ÖK N, YÖRÜKOĞLU Ç, METE G, AKGÜN Ş (2021). Effects of low-density pulsed ultrasound treatment on transforming growth factor-beta, collagen level, histology, biomechanics, and function in repaired rat tendons. , 167 - 174. 10.5606/tftrd.2021.5118 |
| Chicago | İNCEOĞLU ALPEREN,SAHIN FÜSUN,AKKAYA Nuray,ÖK Nusret,YÖRÜKOĞLU Çağdaş,METE Gülçin,AKGÜN Şakir Effects of low-density pulsed ultrasound treatment on transforming growth factor-beta, collagen level, histology, biomechanics, and function in repaired rat tendons. (2021): 167 - 174. 10.5606/tftrd.2021.5118 |
| MLA | İNCEOĞLU ALPEREN,SAHIN FÜSUN,AKKAYA Nuray,ÖK Nusret,YÖRÜKOĞLU Çağdaş,METE Gülçin,AKGÜN Şakir Effects of low-density pulsed ultrasound treatment on transforming growth factor-beta, collagen level, histology, biomechanics, and function in repaired rat tendons. , 2021, ss.167 - 174. 10.5606/tftrd.2021.5118 |
| AMA | İNCEOĞLU A,SAHIN F,AKKAYA N,ÖK N,YÖRÜKOĞLU Ç,METE G,AKGÜN Ş Effects of low-density pulsed ultrasound treatment on transforming growth factor-beta, collagen level, histology, biomechanics, and function in repaired rat tendons. . 2021; 167 - 174. 10.5606/tftrd.2021.5118 |
| Vancouver | İNCEOĞLU A,SAHIN F,AKKAYA N,ÖK N,YÖRÜKOĞLU Ç,METE G,AKGÜN Ş Effects of low-density pulsed ultrasound treatment on transforming growth factor-beta, collagen level, histology, biomechanics, and function in repaired rat tendons. . 2021; 167 - 174. 10.5606/tftrd.2021.5118 |
| IEEE | İNCEOĞLU A,SAHIN F,AKKAYA N,ÖK N,YÖRÜKOĞLU Ç,METE G,AKGÜN Ş "Effects of low-density pulsed ultrasound treatment on transforming growth factor-beta, collagen level, histology, biomechanics, and function in repaired rat tendons." , ss.167 - 174, 2021. 10.5606/tftrd.2021.5118 |
| ISNAD | İNCEOĞLU, ALPEREN vd. "Effects of low-density pulsed ultrasound treatment on transforming growth factor-beta, collagen level, histology, biomechanics, and function in repaired rat tendons". (2021), 167-174. https://doi.org/10.5606/tftrd.2021.5118 |
| APA | İNCEOĞLU A, SAHIN F, AKKAYA N, ÖK N, YÖRÜKOĞLU Ç, METE G, AKGÜN Ş (2021). Effects of low-density pulsed ultrasound treatment on transforming growth factor-beta, collagen level, histology, biomechanics, and function in repaired rat tendons. Turkish Journal of Physical Medicine and Rehabilitation, 67(2), 167 - 174. 10.5606/tftrd.2021.5118 |
| Chicago | İNCEOĞLU ALPEREN,SAHIN FÜSUN,AKKAYA Nuray,ÖK Nusret,YÖRÜKOĞLU Çağdaş,METE Gülçin,AKGÜN Şakir Effects of low-density pulsed ultrasound treatment on transforming growth factor-beta, collagen level, histology, biomechanics, and function in repaired rat tendons. Turkish Journal of Physical Medicine and Rehabilitation 67, no.2 (2021): 167 - 174. 10.5606/tftrd.2021.5118 |
| MLA | İNCEOĞLU ALPEREN,SAHIN FÜSUN,AKKAYA Nuray,ÖK Nusret,YÖRÜKOĞLU Çağdaş,METE Gülçin,AKGÜN Şakir Effects of low-density pulsed ultrasound treatment on transforming growth factor-beta, collagen level, histology, biomechanics, and function in repaired rat tendons. Turkish Journal of Physical Medicine and Rehabilitation, vol.67, no.2, 2021, ss.167 - 174. 10.5606/tftrd.2021.5118 |
| AMA | İNCEOĞLU A,SAHIN F,AKKAYA N,ÖK N,YÖRÜKOĞLU Ç,METE G,AKGÜN Ş Effects of low-density pulsed ultrasound treatment on transforming growth factor-beta, collagen level, histology, biomechanics, and function in repaired rat tendons. Turkish Journal of Physical Medicine and Rehabilitation. 2021; 67(2): 167 - 174. 10.5606/tftrd.2021.5118 |
| Vancouver | İNCEOĞLU A,SAHIN F,AKKAYA N,ÖK N,YÖRÜKOĞLU Ç,METE G,AKGÜN Ş Effects of low-density pulsed ultrasound treatment on transforming growth factor-beta, collagen level, histology, biomechanics, and function in repaired rat tendons. Turkish Journal of Physical Medicine and Rehabilitation. 2021; 67(2): 167 - 174. 10.5606/tftrd.2021.5118 |
| IEEE | İNCEOĞLU A,SAHIN F,AKKAYA N,ÖK N,YÖRÜKOĞLU Ç,METE G,AKGÜN Ş "Effects of low-density pulsed ultrasound treatment on transforming growth factor-beta, collagen level, histology, biomechanics, and function in repaired rat tendons." Turkish Journal of Physical Medicine and Rehabilitation, 67, ss.167 - 174, 2021. 10.5606/tftrd.2021.5118 |
| ISNAD | İNCEOĞLU, ALPEREN vd. "Effects of low-density pulsed ultrasound treatment on transforming growth factor-beta, collagen level, histology, biomechanics, and function in repaired rat tendons". Turkish Journal of Physical Medicine and Rehabilitation 67/2 (2021), 167-174. https://doi.org/10.5606/tftrd.2021.5118 |
