HLA B-27 negatif ve pozitif ankilozan spondilit hastaları farklı mıdır?
Yıl: 2021 Cilt: 13 Sayı: 2 Sayfa Aralığı: 54 - 58 Metin Dili: Türkçe DOI: 10.4274/raed.galenos.2021.49469 İndeks Tarihi: 24-05-2022
HLA B-27 negatif ve pozitif ankilozan spondilit hastaları farklı mıdır?
Öz: Amaç: Ankilozan spondilit (AS), omurga ve sakroiliak eklemleri etkileyen, kronik sistemik inflamatuvar bir hastalıktır. HLA-B27’nin AS ile ilişkisi, bir molekül ve tıptaki insan hastalığı arasında bulunabilecek ilgi çekici modellerden biridir. Bu çalışmada amacımız; HLA-B27 negatif AS hastalarının klinik, laboratuvar verileri, radyolojik özellikleri ve tedavilerinin nasıl olduğunu değerlendirmek ve HLA-B27 pozitif AS hastaları ile karşılaştırmaktı. Yöntem: Bu çalışmada, 1984 Modifiye New York ve 2009 ASAS (Assessment of SpondyloArthritis International Society) sınıflama kriterlerine göre AS tanısı ile takip edilen 451 hastanın dosyaları retrospektif olarak incelendi. HLA-B27 pozitif ve negatif hastaların demografik özellikleri, klinik ve laboratuvar bulguları, tedavileri kaydedildi ve uygun istatistiksel yöntemler ile karşılaştırıldı. Bulgular: Çalışmaya dahil edilen 451 AS hastasının 340’ı (%75,4) HLA-B27 pozitif idi. Her iki hasta grubunda cinsiyet, yaş, semptomların başlama yaşı, tanı yaşı ve tanıda gecikme süresi, radyografik sakroiliit sıklığı ve tedavi tercihleri gruplar arasında farklılık göstermezken (p>0,05, tamamında), üveit HLA-B27 pozitif hasta grubunda (p=0,010), inflamatuvar barsak hastalığı ise HLA-B27 negatif hasta grubunda daha sıktı (p=0,002). Sonuç: Çalışmamızda AS’nin klinik bulguların HLA-B27’nin çok fazla belirleyici olmadığını saptadık. AS patogenezinde, HLA-B27 dışında başka genetik polimorfizmlerin olduğu bilinmektedir. Klinik farklılıkların bir kısmı bu genetik farklılıklardan kaynaklanabilir
Anahtar Kelime: Are HLA B-27 negative and positive ankylosing spondylitis patients different?
Öz: Objective: Ankylosing spondylitis (AS) is a chronic, inflammatory disease affecting the spine and sacroiliac joints. The relation between HLA B-27 and AS is one of the most interesting models for the association between a molecule and human disease. Our aim in this study was to evaluate the clinical, laboratory and radiologic findings and treatment of HLA B-27 negative AS patients and to compare with HLA B-27 positive AS patients. Methods: In this study, medical files of 451 patients who were classified as AS according to 1984 Modified New York and 2009 ASAS (Assessment of SpondyloArthritis International Society) classification criteria were retrospectively evaluated. The demographic features, clinical and laboratory findings and treatments of the HLA B-27 positive and nepative AS patients were recorded and compared with apropriate statistical tests. Results: Of the 451 AS patients, 340 (75.4%) were HLA B-27 positive. Gender, age, age at the beginning of symptoms, age at diagnosis, delay in diagnosis, frequency of radyographic sacroiliitis and treatment choices did not show any difference among groups (p>0.05, for all). Uveitis was more common in HLA B-27 positive AS patients (p=0.010) whereas inflammatory bowel disease was more common in HLA B-27 negative AS patients (p=0.002). Conclusion: In this study, HLA B-27 was not decisive for the features of AS. It is known that there are roles of other genetic polymorphisms in the pathogenesis of AS. Some of the differences may result from these genetic differences.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | ÖNTÜRK Ö, Yasar Bilge N, Bilgin M, KASIFOGLU T (2021). HLA B-27 negatif ve pozitif ankilozan spondilit hastaları farklı mıdır?. , 54 - 58. 10.4274/raed.galenos.2021.49469 |
| Chicago | ÖNTÜRK ÖZGE AYFER,Yasar Bilge Nazife Sule,Bilgin Muzaffer,KASIFOGLU TIMUCIN HLA B-27 negatif ve pozitif ankilozan spondilit hastaları farklı mıdır?. (2021): 54 - 58. 10.4274/raed.galenos.2021.49469 |
| MLA | ÖNTÜRK ÖZGE AYFER,Yasar Bilge Nazife Sule,Bilgin Muzaffer,KASIFOGLU TIMUCIN HLA B-27 negatif ve pozitif ankilozan spondilit hastaları farklı mıdır?. , 2021, ss.54 - 58. 10.4274/raed.galenos.2021.49469 |
| AMA | ÖNTÜRK Ö,Yasar Bilge N,Bilgin M,KASIFOGLU T HLA B-27 negatif ve pozitif ankilozan spondilit hastaları farklı mıdır?. . 2021; 54 - 58. 10.4274/raed.galenos.2021.49469 |
| Vancouver | ÖNTÜRK Ö,Yasar Bilge N,Bilgin M,KASIFOGLU T HLA B-27 negatif ve pozitif ankilozan spondilit hastaları farklı mıdır?. . 2021; 54 - 58. 10.4274/raed.galenos.2021.49469 |
| IEEE | ÖNTÜRK Ö,Yasar Bilge N,Bilgin M,KASIFOGLU T "HLA B-27 negatif ve pozitif ankilozan spondilit hastaları farklı mıdır?." , ss.54 - 58, 2021. 10.4274/raed.galenos.2021.49469 |
| ISNAD | ÖNTÜRK, ÖZGE AYFER vd. "HLA B-27 negatif ve pozitif ankilozan spondilit hastaları farklı mıdır?". (2021), 54-58. https://doi.org/10.4274/raed.galenos.2021.49469 |
| APA | ÖNTÜRK Ö, Yasar Bilge N, Bilgin M, KASIFOGLU T (2021). HLA B-27 negatif ve pozitif ankilozan spondilit hastaları farklı mıdır?. Ulusal Romatoloji Dergisi, 13(2), 54 - 58. 10.4274/raed.galenos.2021.49469 |
| Chicago | ÖNTÜRK ÖZGE AYFER,Yasar Bilge Nazife Sule,Bilgin Muzaffer,KASIFOGLU TIMUCIN HLA B-27 negatif ve pozitif ankilozan spondilit hastaları farklı mıdır?. Ulusal Romatoloji Dergisi 13, no.2 (2021): 54 - 58. 10.4274/raed.galenos.2021.49469 |
| MLA | ÖNTÜRK ÖZGE AYFER,Yasar Bilge Nazife Sule,Bilgin Muzaffer,KASIFOGLU TIMUCIN HLA B-27 negatif ve pozitif ankilozan spondilit hastaları farklı mıdır?. Ulusal Romatoloji Dergisi, vol.13, no.2, 2021, ss.54 - 58. 10.4274/raed.galenos.2021.49469 |
| AMA | ÖNTÜRK Ö,Yasar Bilge N,Bilgin M,KASIFOGLU T HLA B-27 negatif ve pozitif ankilozan spondilit hastaları farklı mıdır?. Ulusal Romatoloji Dergisi. 2021; 13(2): 54 - 58. 10.4274/raed.galenos.2021.49469 |
| Vancouver | ÖNTÜRK Ö,Yasar Bilge N,Bilgin M,KASIFOGLU T HLA B-27 negatif ve pozitif ankilozan spondilit hastaları farklı mıdır?. Ulusal Romatoloji Dergisi. 2021; 13(2): 54 - 58. 10.4274/raed.galenos.2021.49469 |
| IEEE | ÖNTÜRK Ö,Yasar Bilge N,Bilgin M,KASIFOGLU T "HLA B-27 negatif ve pozitif ankilozan spondilit hastaları farklı mıdır?." Ulusal Romatoloji Dergisi, 13, ss.54 - 58, 2021. 10.4274/raed.galenos.2021.49469 |
| ISNAD | ÖNTÜRK, ÖZGE AYFER vd. "HLA B-27 negatif ve pozitif ankilozan spondilit hastaları farklı mıdır?". Ulusal Romatoloji Dergisi 13/2 (2021), 54-58. https://doi.org/10.4274/raed.galenos.2021.49469 |
