TY  - JOUR
TI  - Protective Role of White Cabbage Extract Against Amiodarone-Induced Lung Damage in Rats
AB  - Objective: It was intended to study the protective roles of white cabbage on amiodarone induced lung damage. Materials and Methods: Rats were distributed into 4 groups, Control group, intact animals; WCAE group, animals given white cabbage extract (WCAE, 500 mg/kg) for 7 days; AMD group, animals administered amiodarone (AMD, 100 mg/kg) for 7 days; AMD+WCAE group, animals given white cabbage extract and amiodarone at the same dose. Results: White cabbage extract treatment in AMD+WCAE group showed reduced interstitial edema and congestion, an improvement in alveolar structures besides regression of inflammatory cell infiltration in lung parenchyma. Moreover, a prominent reduction in the amount of collagen fibers deposition in the parenchyma was seen in AMD+WCAE group. Lung levels of glutathione and total antioxidant capacity and activities of glutathione-S-transferase, paraoxonase and carbonic anhydrase were decreased while the activitiesof lipid peroxidation, advanced oxidized protein products, total oxidant status, reactive oxygen species, oxidative stress index, nitric oxide and hydroxy proline levels, catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, lactate dehydrogenase and xanthine oxidase were increased in AMD group. Administration of white cabbage extract reversed these levels and activities in AMD group. Conclusion: In conclusion, white cabbage extract can ameliorate amiodarone induced lung damage. 
AU  - Turkyilmaz, Ismet Burcu
AU  - Ak, Esin
AU  - YANARDAG, REFIYE
AU  - Muhan, Aleyna
DO  - 10.26453/otjhs.1058146
PY  - 2022
JO  - Online Türk Sağlık Bilimleri Dergisi
VL  - 7
IS  - 1
SN  - 2459-1467
SP  - 143
EP  - 150
DB  - TRDizin
UR  - http://search/yayin/detay/508178
ER  -