TY  - JOUR
TI  - The role of protein oxidation in the development of diabetic microvascular complications
AB  - OBJECTIVE: The role of protein oxidation in the development of diabetic microvascular complications was investigated. METHODS: In total, 266 participants were split into five groups: Group 1; diabetes mellitus for at least 10 years without any complications, Group 2; diabetic nephropathy, Group 3; diabetic neuropathy, Group 4; diabetic retinopathy, and Group 5; control group. Thiol, disulfide, ferroxidase, and ischemia-modified albumin (IMA) levels were analyzed in the serum. RESULTS: Native thiol, total thiol, and native thiol/total thiol were lower in Group 4 than Groups 1, 3, and 5 (p<0.001). However, disulfide/native thiol and disulfide/total thiol were higher in Group 4 than all other groups (p<0.001). IMA was higher in Groups 3 and 4 than all other groups (p<0.001). Ferroxidase was lower in Groups 3 and 4 than Group 2 (p<0.001). CONCLUSION: Thiol-disulfide homeostasis impairment in favor of disulfide may have a function in the progress of diabetic retinopathy. Furthermore, the disruptions of IMA and ferroxidase levels involve in the development of diabetic retinopathy and neuropathy.
AU  - ŞİRANLI, GÜLŞAH
AU  - Ozcicek, Adalet
AU  - Ersoy, Alevtina
AU  - ÇOBAN, T. Abdulkadir
AU  - karakurt, yucel
AU  - Bektaş, Özcan
AU  - Mertoglu, Cuma
AU  - gök, gamze
AU  - ARSLAN, YUSUF KEMAL
DO  - 10.14744/nci.2021.33341
PY  - 2021
JO  - İstanbul Kuzey Klinikleri
VL  - 8
IS  - 5
SN  - 2148-4902
SP  - 500
EP  - 506
DB  - TRDizin
UR  - http://search/yayin/detay/508452
ER  -