TY  - JOUR
TI  - Pre-Conditioning Serum Uric Acid as a Risk Factor for Sinusoidal
Obstruction Syndrome of the Liver in Children Undergoing
Hematopoietic Stem Cell Transplantation
AB  - Objective: Uric acid (UA), a known danger signal released from
injured cells, is a valuable sign of inflammation. We aimed to evaluate
the association of serum UA levels before the start of conditioning
regimens with the risk of hepatic sinusoidal obstruction syndrome
(SOS) development after hematopoietic stem cell transplantation
(HSCT).
Materials and Methods: Two hundred and twenty-two children who
underwent allogeneic HSCT at the Pediatric BMT Unit of Hacettepe
University between 2000 and 2014 were included in this retrospective
study. Serum UA levels were measured before conditioning as an
indicator of the pre-transplant inflammatory status of the patients.
Patients with and without a diagnosis of SOS were compared regarding
primary diagnosis, previously described risk factors for SOS, and preconditioning
serum UA.
Results: SOS was diagnosed in 42 patients who had higher
pre-conditioning serum UA levels compared to those who did not.
Pre-transplant serum creatinine, gamma-glutamyl transferase,
bilirubin, ferritin, and C-reactive protein levels did not differ
significantly among patients with and without SOS; however, serum
albumin was lower in the patients who developed SOS. Receiver
operating characteristic analysis revealed that a pre-conditioning UA
level higher than 3.32 mg/dL was predictive of SOS. When applied
to a multivariate model, only pre-conditioning UA and albumin
levels remained significant risk factors for SOS (UA: odds ratio
[OR], 2.54; 95% confidence interval [CI], 1.26-5.12, p=0.009; albumin:
OR, 0.45, 95% CI, 0.22-0.95, p=0.037).
Conclusion: Our results suggest that pre-conditioning serum UA is
an independent risk factor for SOS, and it might be used as an early
predictor of hepatic SOS together with previously described clinical
and laboratory parameters.
AU  - Kuskonmaz, Baris
AU  - ARSLAN, Umut Ece
AU  - WARASNHE, Khaled Warasnhe Khaled
AU  - Karapapak, Murat
AU  - OKUR, FATMA VISAL
AU  - ÇETİNKAYA, Duygu
DO  - 10.4274/tjh.galenos.2021.2021.0174
PY  - 2021
JO  - Turkish Journal of Hematology
VL  - 38
IS  - 4
SN  - 1300-7777
SP  - 286
EP  - 293
DB  - TRDizin
UR  - http://search/yayin/detay/508850
ER  -