Convalescent Plasma Reduces Endogenous Antibody Response in COVID-19: A Retrospective Cross-Sectional Study
Yıl: 2021 Cilt: 38 Sayı: 4 Sayfa Aralığı: 321 - 324 Metin Dili: İngilizce DOI: 10.4274/tjh.galenos.2021.2021.0277 İndeks Tarihi: 25-05-2022
Convalescent Plasma Reduces Endogenous Antibody Response in COVID-19: A Retrospective Cross-Sectional Study
Öz: Objective: The aim of this study is to investigate post-COVID-19
antibody titers in patients who received convalescent plasma (CP) in
addition to standard-of-care treatment.
Materials and Methods: Hospitalized COVID-19 patients who received
CP in addition to standard care were retrospectively investigated.
Patients who received CP with a recorded total COVID-19 antibody
test result after treatment were included. From among hospitalized
COVID-19 patients who received only standard care with a recorded
total COVID-19 antibody test result, a control group matched for age,
gender, and comorbidities was formed. Total COVID-19 antibody index
levels were compared.
Results: Thirty-three CP recipients were enrolled in the study. The
control group consisted of 34 age-, gender-, and comorbiditymatched
standard-care patients. Median total COVID-19 antibody
index levels were significantly reduced in the CP group.
Conclusion: Although CP therapy may have benefits for disease
outcome, its potential ability to hamper long-term immunity may be
a problem.
Anahtar Kelime: Konvalesan Plazma COVID-19’da Endojen Antikor Yanıtını Azaltır: Retrospektif Kesitsel Bir Çalışma
Öz: Amaç: Çalışmanın amacı tedavi sürecinde standart tedavilere ek olarak
konvalesan plazma (KP) tedavisi uygulanan COVID-19 hastalarında
takipte oluşan COVID-19 antikor düzeylerini incelemektir.
Gereç ve Yöntemler: Yatarak tedavi alan COVID-19 hastaları içinde
standart tedavilere ek olarak KP tedavisi alanlar retrospektif olarak
incelenmiştir ve takipte COVID-19 antikor düzeyleri bakılmış olanlar
çalışmaya dahil edilmiştir. Aynı zaman zarfında yatarak takip edilen,
standart tedavi alan ve takipte COVID-19 antikor düzeyi bakılmış
olan COVID-19 hastaları arasından yaş, cinsiyet ve komorbidite sıklığı
eşleştirilmiş bir kontrol grubu oluşturulmuştur. İki grup arasında
COVID-19 antikor düzeyleri karşılaştırılmıştır.
Bulgular: KP tedavisi alan ve takipte antikor düzeyleri bakılmış olan
33 COVID-19 hastası çalışmaya dahil edildi. Kontrol grubunda 34 hasta
mevcuttu. Median total COVID-19 antikor indeks düzeyleri standart
yaklaşıma ek olarak KP alan grupta anlamlı olarak düşük saptandı.
Sonuç: KP tedavisinin COVID-19 hastalarında sonuçlar üzerine olumlu
etkileri görülmekle beraber hastalık sonrasında azalmış antikor yanıtı,
uzun dönem bağışıklık üzerine olumsuz etkilerin bir göstergesi olabilir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Omma A, ERDEN A, Güven S, ateş i, KÜÇÜKŞAHİN O (2021). Convalescent Plasma Reduces Endogenous Antibody Response in COVID-19: A Retrospective Cross-Sectional Study. , 321 - 324. 10.4274/tjh.galenos.2021.2021.0277 |
| Chicago | Omma Ahmet,ERDEN Abdulsamet,Güven Serdar Can,ateş ihsan,KÜÇÜKŞAHİN Orhan Convalescent Plasma Reduces Endogenous Antibody Response in COVID-19: A Retrospective Cross-Sectional Study. (2021): 321 - 324. 10.4274/tjh.galenos.2021.2021.0277 |
| MLA | Omma Ahmet,ERDEN Abdulsamet,Güven Serdar Can,ateş ihsan,KÜÇÜKŞAHİN Orhan Convalescent Plasma Reduces Endogenous Antibody Response in COVID-19: A Retrospective Cross-Sectional Study. , 2021, ss.321 - 324. 10.4274/tjh.galenos.2021.2021.0277 |
| AMA | Omma A,ERDEN A,Güven S,ateş i,KÜÇÜKŞAHİN O Convalescent Plasma Reduces Endogenous Antibody Response in COVID-19: A Retrospective Cross-Sectional Study. . 2021; 321 - 324. 10.4274/tjh.galenos.2021.2021.0277 |
| Vancouver | Omma A,ERDEN A,Güven S,ateş i,KÜÇÜKŞAHİN O Convalescent Plasma Reduces Endogenous Antibody Response in COVID-19: A Retrospective Cross-Sectional Study. . 2021; 321 - 324. 10.4274/tjh.galenos.2021.2021.0277 |
| IEEE | Omma A,ERDEN A,Güven S,ateş i,KÜÇÜKŞAHİN O "Convalescent Plasma Reduces Endogenous Antibody Response in COVID-19: A Retrospective Cross-Sectional Study." , ss.321 - 324, 2021. 10.4274/tjh.galenos.2021.2021.0277 |
| ISNAD | Omma, Ahmet vd. "Convalescent Plasma Reduces Endogenous Antibody Response in COVID-19: A Retrospective Cross-Sectional Study". (2021), 321-324. https://doi.org/10.4274/tjh.galenos.2021.2021.0277 |
| APA | Omma A, ERDEN A, Güven S, ateş i, KÜÇÜKŞAHİN O (2021). Convalescent Plasma Reduces Endogenous Antibody Response in COVID-19: A Retrospective Cross-Sectional Study. Turkish Journal of Hematology, 38(4), 321 - 324. 10.4274/tjh.galenos.2021.2021.0277 |
| Chicago | Omma Ahmet,ERDEN Abdulsamet,Güven Serdar Can,ateş ihsan,KÜÇÜKŞAHİN Orhan Convalescent Plasma Reduces Endogenous Antibody Response in COVID-19: A Retrospective Cross-Sectional Study. Turkish Journal of Hematology 38, no.4 (2021): 321 - 324. 10.4274/tjh.galenos.2021.2021.0277 |
| MLA | Omma Ahmet,ERDEN Abdulsamet,Güven Serdar Can,ateş ihsan,KÜÇÜKŞAHİN Orhan Convalescent Plasma Reduces Endogenous Antibody Response in COVID-19: A Retrospective Cross-Sectional Study. Turkish Journal of Hematology, vol.38, no.4, 2021, ss.321 - 324. 10.4274/tjh.galenos.2021.2021.0277 |
| AMA | Omma A,ERDEN A,Güven S,ateş i,KÜÇÜKŞAHİN O Convalescent Plasma Reduces Endogenous Antibody Response in COVID-19: A Retrospective Cross-Sectional Study. Turkish Journal of Hematology. 2021; 38(4): 321 - 324. 10.4274/tjh.galenos.2021.2021.0277 |
| Vancouver | Omma A,ERDEN A,Güven S,ateş i,KÜÇÜKŞAHİN O Convalescent Plasma Reduces Endogenous Antibody Response in COVID-19: A Retrospective Cross-Sectional Study. Turkish Journal of Hematology. 2021; 38(4): 321 - 324. 10.4274/tjh.galenos.2021.2021.0277 |
| IEEE | Omma A,ERDEN A,Güven S,ateş i,KÜÇÜKŞAHİN O "Convalescent Plasma Reduces Endogenous Antibody Response in COVID-19: A Retrospective Cross-Sectional Study." Turkish Journal of Hematology, 38, ss.321 - 324, 2021. 10.4274/tjh.galenos.2021.2021.0277 |
| ISNAD | Omma, Ahmet vd. "Convalescent Plasma Reduces Endogenous Antibody Response in COVID-19: A Retrospective Cross-Sectional Study". Turkish Journal of Hematology 38/4 (2021), 321-324. https://doi.org/10.4274/tjh.galenos.2021.2021.0277 |
