Can surgical adhesives may cause false positivity in follow-up positron emission tomography after lung cancer resection?
Yıl: 2021 Cilt: 69 Sayı: 1 Sayfa Aralığı: 59 - 64 Metin Dili: İngilizce DOI: 10.5578/tt.20219907 İndeks Tarihi: 25-05-2022
Can surgical adhesives may cause false positivity in follow-up positron emission tomography after lung cancer resection?
Öz: Can surgical adhesives may cause false positivity in follow-up positron
emission tomography after lung cancer resection?
Introduction: Postoperative complications following thoracic procedures are
a major cause of morbidity and mortality. Alveolar air leaks and/or bronchopleural fistulas are associated with increased risk of infection, prolonged chest
tube, and hospital stay duration and therefore generate economical concern
for health care providers. A variety of surgical sealants or adhesives have been
introduced to overcome this complication. Since intraoperative BioGlue®
application can also cause an inflammatory reaction and mimic tumor recurrence on FDG PET-CT, in the present study we aimed to investigate its potential role in false-positive PET-CT results in patients operated for NSCLC.
Materials and Methods: Data of six patients who underwent resection for
primary NSCLC at our institution (Department of Thoracic Surgery, Hacettepe
University Medical Faculty) between January 2015 and December 2018 and
had false positivity, due to BioGlue® application, at the bronchial stump in
follow-up FDG PET-CT were retrospectively analyzed from a prospectively
collected database.
Results: One of the 6 patients was female and 5 were male. The mean age was 68 years (range, 56-79 years). The average time
interval between operation and postoperative FDG-PET imaging was 4.3 months (range, 4-6 months). Follow-up FDG-PET imaging
SUVmax values ranged between 3.0 and 9.0 (median: 5.33). All patients have been evaluated by FDG-PET scan following the detection of soft tissue densities at the surgical site suspicious for recurrence at their follow-up chest CT scans. Four patients underwent a
bronchoscopic examination, bronchial stumps were examined and multiple biopsies were taken from suspicious nodules or tissues
and sent for pathologic examination. Histopathological results revealed inflammation which is compatible with foreign body granuloma, without any suspicion for malignancy, in all cases. Two patients were solely followed-up and subsequent FDG-PET imaging after
3 months revealed complete resolution of FDG uptake.
Conclusion: To avoid unnecessary biopsies or surgical procedures, the possibility of false-positive results due to surgical adhesive
product use should be taken into account while interpreting follow-up FDG-PET imaging results and the operative reports should be
written in detail, describing which surgical materials used and their exact application sites.
Anahtar Kelime: Cerrahi doku yapıştırıcılar akciğer kanseri rezeksiyonu sonrası takip pozitron emisyon tomografisinde yanlış pozitifliğe neden olur mu?
Öz: Giriş: Torasik cerrahi uygulamaları sonrasında gelişen postoperatif komplikasyonlar, morbidite ve mortalitenin önemli bir nedenidir.
Alveolar hava kaçakları ve / veya bronkoplevral fistüller, artan enfeksiyon riski, göğüs tüpünün uzun süre bulunması ve uzun süre
hastanede kalış ile ilişkilidir. Bu nedenler sağlık hizmeti sağlayıcıları için ekonomik endişe yaratır. Bu komplikasyonun üstesinden
gelmek için çeşitli cerrahi sızdırmazlık malzemeleri veya yapıştırıcılar piyasaya sürülmüştür. İntraoperatif BioGlue® uygulaması da FDG
PET-BT’de enflamatuar reaksiyona yol açıp tümör nüksünü taklit edebildiğinden, bu çalışmada KHDAK (küçük hücreli dışı akciğer
kanseri) için ameliyat edilen hastalarda cerrahi doku yapıştırıcı uygulamasının yanlış pozitif PET-BT sonuçlarındaki potansiyel rolünü
araştırmayı amaçladık.
Materyal ve Metod: Ocak 2015-Aralık 2018 tarihleri arasında kurumumuzda (Hacettepe Üniversitesi Tıp Fakültesi Göğüs Cerrahisi
Anabilim Dalı) primer KHDAK nedeniyle rezeksiyon yapılan ve takip FDG PET-BT’de bronşiyal güdükte BioGlue® uygulaması nedeniyle yanlış pozitifliği olan altı hastanın verileri, prospektif olarak toplanan bir veri tabanından geriye dönük olarak analiz edildi.
Bulgular: 6 hastadan biri kadın, 5’i erkekti. Ortalama yaş 68 yıldı (aralık, 56-79 yaş). Operasyon ile postoperatif FDG-PET görüntüleme arasındaki ortalama süre 4,3 aydı (aralık, 4-6 ay). Takip FDG-PET görüntüleme SUVmax değerleri 3,0 ile 9,0 (medyan: 5,33)
arasında değişti. Tüm hastalar, takip göğüs BT taramalarında nüks şüphesi olan cerrahi bölgede yumuşak doku yoğunluklarının saptanmasının ardından FDG-PET taraması ile değerlendirildi. Dört hastaya bronkoskopik inceleme yapıldı, bronşiyal güdükler incelendi
ve şüpheli nodül veya dokulardan çok sayıda biyopsi alınarak patolojik incelemeye gönderildi. Histopatolojik sonuçlar, tüm olgularda
malignite şüphesi olmaksızın yabancı cisim granülomu ile uyumlu inflamasyonu ortaya çıkardı. İki hasta sadece takip edildi ve 3 ay
sonra FDG-PET görüntülemesi FDG alımının tamamen çözüldüğünü gösterdi.
Sonuç: Gereksiz biyopsilerden veya cerrahi işlemlerden kaçınmak için, takip FDG-PET görüntüleme sonuçları yorumlanırken cerrahi
yapıştırıcı ürün kullanımına bağlı yanlış pozitif sonuç olasılığı göz önünde bulundurulmalı ve ameliyat raporları ayrıntılı olarak hangi
cerrahi materyaller açıklanarak yazılmalıdır
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Doğan R, UYSAL S, Kumbasar U, Köksal D, ANCIN B, Tuncel M (2021). Can surgical adhesives may cause false positivity in follow-up positron emission tomography after lung cancer resection?. , 59 - 64. 10.5578/tt.20219907 |
| Chicago | Doğan Rıza,UYSAL SERKAN,Kumbasar Ulaş,Köksal Deniz,ANCIN BURCU,Tuncel Murat Can surgical adhesives may cause false positivity in follow-up positron emission tomography after lung cancer resection?. (2021): 59 - 64. 10.5578/tt.20219907 |
| MLA | Doğan Rıza,UYSAL SERKAN,Kumbasar Ulaş,Köksal Deniz,ANCIN BURCU,Tuncel Murat Can surgical adhesives may cause false positivity in follow-up positron emission tomography after lung cancer resection?. , 2021, ss.59 - 64. 10.5578/tt.20219907 |
| AMA | Doğan R,UYSAL S,Kumbasar U,Köksal D,ANCIN B,Tuncel M Can surgical adhesives may cause false positivity in follow-up positron emission tomography after lung cancer resection?. . 2021; 59 - 64. 10.5578/tt.20219907 |
| Vancouver | Doğan R,UYSAL S,Kumbasar U,Köksal D,ANCIN B,Tuncel M Can surgical adhesives may cause false positivity in follow-up positron emission tomography after lung cancer resection?. . 2021; 59 - 64. 10.5578/tt.20219907 |
| IEEE | Doğan R,UYSAL S,Kumbasar U,Köksal D,ANCIN B,Tuncel M "Can surgical adhesives may cause false positivity in follow-up positron emission tomography after lung cancer resection?." , ss.59 - 64, 2021. 10.5578/tt.20219907 |
| ISNAD | Doğan, Rıza vd. "Can surgical adhesives may cause false positivity in follow-up positron emission tomography after lung cancer resection?". (2021), 59-64. https://doi.org/10.5578/tt.20219907 |
| APA | Doğan R, UYSAL S, Kumbasar U, Köksal D, ANCIN B, Tuncel M (2021). Can surgical adhesives may cause false positivity in follow-up positron emission tomography after lung cancer resection?. Tüberküloz ve Toraks, 69(1), 59 - 64. 10.5578/tt.20219907 |
| Chicago | Doğan Rıza,UYSAL SERKAN,Kumbasar Ulaş,Köksal Deniz,ANCIN BURCU,Tuncel Murat Can surgical adhesives may cause false positivity in follow-up positron emission tomography after lung cancer resection?. Tüberküloz ve Toraks 69, no.1 (2021): 59 - 64. 10.5578/tt.20219907 |
| MLA | Doğan Rıza,UYSAL SERKAN,Kumbasar Ulaş,Köksal Deniz,ANCIN BURCU,Tuncel Murat Can surgical adhesives may cause false positivity in follow-up positron emission tomography after lung cancer resection?. Tüberküloz ve Toraks, vol.69, no.1, 2021, ss.59 - 64. 10.5578/tt.20219907 |
| AMA | Doğan R,UYSAL S,Kumbasar U,Köksal D,ANCIN B,Tuncel M Can surgical adhesives may cause false positivity in follow-up positron emission tomography after lung cancer resection?. Tüberküloz ve Toraks. 2021; 69(1): 59 - 64. 10.5578/tt.20219907 |
| Vancouver | Doğan R,UYSAL S,Kumbasar U,Köksal D,ANCIN B,Tuncel M Can surgical adhesives may cause false positivity in follow-up positron emission tomography after lung cancer resection?. Tüberküloz ve Toraks. 2021; 69(1): 59 - 64. 10.5578/tt.20219907 |
| IEEE | Doğan R,UYSAL S,Kumbasar U,Köksal D,ANCIN B,Tuncel M "Can surgical adhesives may cause false positivity in follow-up positron emission tomography after lung cancer resection?." Tüberküloz ve Toraks, 69, ss.59 - 64, 2021. 10.5578/tt.20219907 |
| ISNAD | Doğan, Rıza vd. "Can surgical adhesives may cause false positivity in follow-up positron emission tomography after lung cancer resection?". Tüberküloz ve Toraks 69/1 (2021), 59-64. https://doi.org/10.5578/tt.20219907 |
