TY  - JOUR
TI  - Can surgical adhesives may cause false
positivity in follow-up positron emission
tomography after lung cancer resection?
AB  - Can surgical adhesives may cause false positivity in follow-up positron
emission tomography after lung cancer resection?
Introduction: Postoperative complications following thoracic procedures are
a major cause of morbidity and mortality. Alveolar air leaks and/or bronchopleural fistulas are associated with increased risk of infection, prolonged chest
tube, and hospital stay duration and therefore generate economical concern
for health care providers. A variety of surgical sealants or adhesives have been
introduced to overcome this complication. Since intraoperative BioGlue®
application can also cause an inflammatory reaction and mimic tumor recurrence on FDG PET-CT, in the present study we aimed to investigate its potential role in false-positive PET-CT results in patients operated for NSCLC.
Materials and Methods: Data of six patients who underwent resection for
primary NSCLC at our institution (Department of Thoracic Surgery, Hacettepe
University Medical Faculty) between January 2015 and December 2018 and
had false positivity, due to BioGlue® application, at the bronchial stump in
follow-up FDG PET-CT were retrospectively analyzed from a prospectively
collected database.
Results: One of the 6 patients was female and 5 were male. The mean age was 68 years (range, 56-79 years). The average time
interval between operation and postoperative FDG-PET imaging was 4.3 months (range, 4-6 months). Follow-up FDG-PET imaging
SUVmax values ranged between 3.0 and 9.0 (median: 5.33). All patients have been evaluated by FDG-PET scan following the detection of soft tissue densities at the surgical site suspicious for recurrence at their follow-up chest CT scans. Four patients underwent a
bronchoscopic examination, bronchial stumps were examined and multiple biopsies were taken from suspicious nodules or tissues
and sent for pathologic examination. Histopathological results revealed inflammation which is compatible with foreign body granuloma, without any suspicion for malignancy, in all cases. Two patients were solely followed-up and subsequent FDG-PET imaging after
3 months revealed complete resolution of FDG uptake.
Conclusion: To avoid unnecessary biopsies or surgical procedures, the possibility of false-positive results due to surgical adhesive
product use should be taken into account while interpreting follow-up FDG-PET imaging results and the operative reports should be
written in detail, describing which surgical materials used and their exact application sites.
AU  - Doğan, Rıza
AU  - Kumbasar, Ulaş
AU  - Köksal, Deniz
AU  - ANCIN, BURCU
AU  - UYSAL, SERKAN
AU  - Tuncel, Murat
DO  - 10.5578/tt.20219907
PY  - 2021
JO  - Tüberküloz ve Toraks
VL  - 69
IS  - 1
SN  - 0494-1373
SP  - 59
EP  - 64
DB  - TRDizin
UR  - http://search/yayin/detay/509047
ER  -