Three-Dimensional Analysis of Round Window 
Membrane in the Chinchilla Model with Acute Otitis 
Media Induced with Streptococcus Pneumoniae 7F

Keskin, Nevra; Börkü, Mehmet Kazim; Paparella, Michael; Albasan, Hasan; Cureoglu, Sebahattin

doi:10.4274/tao.2021.5998

Three-Dimensional Analysis of Round Window Membrane in the Chinchilla Model with Acute Otitis Media Induced with Streptococcus Pneumoniae 7F

Nevra Keskin YILMAZ, (Ankara Üniversitesi, Veteriner Fakültesi, İç Hastalıkları Anabilim Dalı, Ankara, TÜRKİYE)

Hasan ALBASAN, (Pet Depot Veterinary Group, La Verne, California, Amerika Birleşik Devletleri)

Mehmet Kazım BÖRKÜ, (Ankara Üniversitesi, Veteriner Fakültesi, İç Hastalıkları Anabilim Dalı, Ankara, TÜRKİYE)

Michael PAPARELLA, (University of Minnesota Medical School, Department of Otorhinolaryngology, Head and Neck Surgery, Minnesota, Amerika Birleşik Devletleri)

Sebahattin CÜREOĞLU (University of Minnesota Medical School, Department of Otorhinolaryngology, Head and Neck Surgery, Minnesota, Amerika Birleşik Devletleri)

Turkish archives of otorhinolaryngology

2 0

Yıl: 2021 Cilt: 59 Sayı: 1 Sayfa Aralığı: 43 - 48 Metin Dili: İngilizce DOI: 10.4274/tao.2021.5998 İndeks Tarihi: 25-05-2022

Three-Dimensional Analysis of Round Window Membrane in the Chinchilla Model with Acute Otitis Media Induced with Streptococcus Pneumoniae 7F

Öz:

Objective: The purpose of this study was to investigate the morphological changes of round window membrane (RWM) in chinchillas with Streptococcus pneumoniae (S. pneumoniae) serotype 7F induced acute otitis media (AOM) by two dimensional (2D) and three dimensional (3D) measurements. Methods: Temporal bone specimens taken from 12 chinchillas were divided into two groups. The control group consisted of healthy animals that were injected with intrabullar saline. The subjects in the experimental group were induced with AOM by intrabullar injection of S. pneumoniae 7F. The 2D and 3D measurements of RWM were compared between the groups. Results: Dramatic changes were noted in the RWM of the experimental group compared to the control group. The thickness [mean ± standard deviation (SD)] of the RWM was significantly (p<0.05) increased in the experimental group compared to the control group by 2D measurements taken at three different points of RWM. Moreover, 3D measurements revealed that the volume (mean ± SD) of RWM was significantly (p=0.009) increased in the experimental group. Conclusion: The results of our study, which indicated significant change in RWM in both 2D and 3D measurements, may shed light on the relationship between AOM and inner ear diseases. Based on our results, we recommend evaluating 3D analyses of RWM, which provide useful data, to better understand the changes in the membrane.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Keskin N, Albasan H, Börkü M, Paparella M, Cureoglu S (2021). Three-Dimensional Analysis of Round Window Membrane in the Chinchilla Model with Acute Otitis Media Induced with Streptococcus Pneumoniae 7F . , 43 - 48. 10.4274/tao.2021.5998
Chicago	Keskin Nevra,Albasan Hasan,Börkü Mehmet Kazim,Paparella Michael,Cureoglu Sebahattin Three-Dimensional Analysis of Round Window Membrane in the Chinchilla Model with Acute Otitis Media Induced with Streptococcus Pneumoniae 7F . (2021): 43 - 48. 10.4274/tao.2021.5998
MLA	Keskin Nevra,Albasan Hasan,Börkü Mehmet Kazim,Paparella Michael,Cureoglu Sebahattin Three-Dimensional Analysis of Round Window Membrane in the Chinchilla Model with Acute Otitis Media Induced with Streptococcus Pneumoniae 7F . , 2021, ss.43 - 48. 10.4274/tao.2021.5998
AMA	Keskin N,Albasan H,Börkü M,Paparella M,Cureoglu S Three-Dimensional Analysis of Round Window Membrane in the Chinchilla Model with Acute Otitis Media Induced with Streptococcus Pneumoniae 7F . . 2021; 43 - 48. 10.4274/tao.2021.5998
Vancouver	Keskin N,Albasan H,Börkü M,Paparella M,Cureoglu S Three-Dimensional Analysis of Round Window Membrane in the Chinchilla Model with Acute Otitis Media Induced with Streptococcus Pneumoniae 7F . . 2021; 43 - 48. 10.4274/tao.2021.5998
IEEE	Keskin N,Albasan H,Börkü M,Paparella M,Cureoglu S "Three-Dimensional Analysis of Round Window Membrane in the Chinchilla Model with Acute Otitis Media Induced with Streptococcus Pneumoniae 7F ." , ss.43 - 48, 2021. 10.4274/tao.2021.5998
ISNAD	Keskin, Nevra vd. "Three-Dimensional Analysis of Round Window Membrane in the Chinchilla Model with Acute Otitis Media Induced with Streptococcus Pneumoniae 7F ". (2021), 43-48. https://doi.org/10.4274/tao.2021.5998

APA	Keskin N, Albasan H, Börkü M, Paparella M, Cureoglu S (2021). Three-Dimensional Analysis of Round Window Membrane in the Chinchilla Model with Acute Otitis Media Induced with Streptococcus Pneumoniae 7F . Turkish archives of otorhinolaryngology , 59(1), 43 - 48. 10.4274/tao.2021.5998
Chicago	Keskin Nevra,Albasan Hasan,Börkü Mehmet Kazim,Paparella Michael,Cureoglu Sebahattin Three-Dimensional Analysis of Round Window Membrane in the Chinchilla Model with Acute Otitis Media Induced with Streptococcus Pneumoniae 7F . Turkish archives of otorhinolaryngology 59, no.1 (2021): 43 - 48. 10.4274/tao.2021.5998
MLA	Keskin Nevra,Albasan Hasan,Börkü Mehmet Kazim,Paparella Michael,Cureoglu Sebahattin Three-Dimensional Analysis of Round Window Membrane in the Chinchilla Model with Acute Otitis Media Induced with Streptococcus Pneumoniae 7F . Turkish archives of otorhinolaryngology , vol.59, no.1, 2021, ss.43 - 48. 10.4274/tao.2021.5998
AMA	Keskin N,Albasan H,Börkü M,Paparella M,Cureoglu S Three-Dimensional Analysis of Round Window Membrane in the Chinchilla Model with Acute Otitis Media Induced with Streptococcus Pneumoniae 7F . Turkish archives of otorhinolaryngology . 2021; 59(1): 43 - 48. 10.4274/tao.2021.5998
Vancouver	Keskin N,Albasan H,Börkü M,Paparella M,Cureoglu S Three-Dimensional Analysis of Round Window Membrane in the Chinchilla Model with Acute Otitis Media Induced with Streptococcus Pneumoniae 7F . Turkish archives of otorhinolaryngology . 2021; 59(1): 43 - 48. 10.4274/tao.2021.5998
IEEE	Keskin N,Albasan H,Börkü M,Paparella M,Cureoglu S "Three-Dimensional Analysis of Round Window Membrane in the Chinchilla Model with Acute Otitis Media Induced with Streptococcus Pneumoniae 7F ." Turkish archives of otorhinolaryngology , 59, ss.43 - 48, 2021. 10.4274/tao.2021.5998
ISNAD	Keskin, Nevra vd. "Three-Dimensional Analysis of Round Window Membrane in the Chinchilla Model with Acute Otitis Media Induced with Streptococcus Pneumoniae 7F ". Turkish archives of otorhinolaryngology 59/1 (2021), 43-48. https://doi.org/10.4274/tao.2021.5998