TY  - JOUR
TI  - Three-Dimensional Analysis of Round Window 
Membrane in the Chinchilla Model with Acute Otitis 
Media Induced with Streptococcus Pneumoniae 7F
AB  - Objective: The purpose of this study was to investigate the morphological changes of round 
window membrane (RWM) in chinchillas with Streptococcus pneumoniae (S. pneumoniae) serotype 
7F induced acute otitis media (AOM) by two dimensional (2D) and three dimensional (3D) 
measurements.
Methods: Temporal bone specimens taken from 12 chinchillas were divided into two groups. The 
control group consisted of healthy animals that were injected with intrabullar saline. The subjects 
in the experimental group were induced with AOM by intrabullar injection of S. pneumoniae 7F. 
The 2D and 3D measurements of RWM were compared between the groups.
Results: Dramatic changes were noted in the RWM of the experimental group compared to the 
control group. The thickness [mean ± standard deviation (SD)] of the RWM was significantly 
(p<0.05) increased in the experimental group compared to the control group by 2D measurements 
taken at three different points of RWM. Moreover, 3D measurements revealed that the volume 
(mean ± SD) of RWM was significantly (p=0.009) increased in the experimental group. 
Conclusion: The results of our study, which indicated significant change in RWM in both 2D 
and 3D measurements, may shed light on the relationship between AOM and inner ear diseases. 
Based on our results, we recommend evaluating 3D analyses of RWM, which provide useful data, 
to better understand the changes in the membrane.
AU  - Keskin, Nevra
AU  - Börkü, Mehmet Kazim
AU  - Paparella, Michael
AU  - Albasan, Hasan
AU  - Cureoglu, Sebahattin
DO  - 10.4274/tao.2021.5998
PY  - 2021
JO  - Turkish archives of otorhinolaryngology 
VL  - 59
IS  - 1
SN  - 2667-7466
SP  - 43
EP  - 48
DB  - TRDizin
UR  - http://search/yayin/detay/509174
ER  -