TY  - JOUR
TI  - BLADDER PRESERVATION WITH IMAGE- GUIDED RADIOTHERAPY FOR ELDERLY PATIENTS WITH MUSCLE-INVASIVE BLADDER
CANCER: A SINGLE INSTUTION EXPERIENCE
AB  - Introduction: The number of elderly patients with bladder cancer is
expected to triple in the coming years in proportion to the increasing
elderly population in the world. The aim of this study was to identify the
prognostic factors affecting survival among elderly patients undergoing
chemoradiotherapy for muscle-invasive bladder cancer.

Materials and Method: We retrospectively reviewed medical records from
93 biopsy-proven nonmetastatic elderly patients with bladder cancer ≥ 65 years
who were treated with helical tomotherapy. The patients received 64.8 Gy to
the bladder with concurrent intravenous cisplatin (40 mg/m2) chemotherapy
weekly as a radiosensitizer.

Results: The mean follow-up time was 34.1 months (range, 4.0–99.1
months). The two- and five-year overall survival, disease-free survival, and
cancer-specific survival rates were 70.6%, and 36.9%, 50.6% and 28.5%,
89.1%, and 58.5%, respectively. Multivariate analysis indicated that urothelial
obstruction was an independent prognostic factor affecting survival rates. No
grade 4 adverse events and deaths attributable to treatment occurred during
chemoradiotherapy

Conclusion: Image guided radiotherapy with chemotherapy as a bladder-
sparing approach is a tolerable alternative therapeutic option without severe
acute and late toxicities in elderly patients who are unfit for radical cystectomy
or refuse surgery.
AU  - gedik, sonay
AU  - AYNACI, ÖZLEM
AU  - yaşar zengin, ahmet
AU  - Savli, Evrim
AU  - HANEDAN USLU, Gonca
AU  - TÜRKER SERDAR, LASİF
DO  - 10.31086/tjgeri.2021.213
PY  - 2021
JO  - Türk Geriatri Dergisi
VL  - 24
IS  - 2
SN  - 1304-2947
SP  - 174
EP  - 184
DB  - TRDizin
UR  - http://search/yayin/detay/509751
ER  -