COENZYME Q10 EFFECTIVELY PREVENTS AGE-RELATED HEARING LOSS IN C57BL/6 MICE
Yıl: 2021 Cilt: 24 Sayı: 2 Sayfa Aralığı: 235 - 243 Metin Dili: İngilizce DOI: 10.31086/tjgeri.2021.220 İndeks Tarihi: 26-05-2022
COENZYME Q10 EFFECTIVELY PREVENTS AGE-RELATED HEARING LOSS IN C57BL/6 MICE
Öz: Introduction: Presbycusis is characterized by gradual, progressive
sensorineural hearing loss. The aim of this study is to evaluate the effects of
coenzyme Q10 in the prevention and treatment of age-related hearing loss.
Materials and Method: Thirty-two C57BL/6 mice were assigned into four
groups as early treatment, late treatment, control and sham control. Treatment
was started at three months of age in the early treatment group and at six
months in the late treatment group. The auditory brainstem test was performed
once every three months. At the end of the study period, the cochleae of the
animals were harvested, and Bcl-2, Bcl-xL, iNOS, COX-2, NF-κB, Bax, and Bak
levels were analyzed with real-time polymerase chain reaction.
Results: The hearing thresholds of the mice in the early treatment group
were better than those of the other groups (p < 0.001). Hearing levels were also
better in the late treatment group than control groups, but the difference was
not significant (p > 0.05). The threshold shift in the early treatment group was
significantly lower than the control groups (p < 0.001). The mRNA expression
levels of proapoptotic genes Bax and Bak were lower (p < 0.05), antiapoptotic
genes Bcl-2 and Bcl-xL were higher (p < 0.05), and the NF-κB, COX-2, and
iNOS genes, which play a role in inflammation, were lower (p < 0.05) in the
early treatment group.
Conclusion: These results suggest that coenzyme Q10 effectively attenuates
the presentation of age-related hearing loss, especially when started before
the onset of hearing loss.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA | Muderris T, Sevil E, yar sağlam a, Babademez M (2021). COENZYME Q10 EFFECTIVELY PREVENTS AGE-RELATED HEARING LOSS IN C57BL/6 MICE. , 235 - 243. 10.31086/tjgeri.2021.220 |
Chicago | Muderris Togay,Sevil Ergun,yar sağlam atiye seda,Babademez Mehmet Ali COENZYME Q10 EFFECTIVELY PREVENTS AGE-RELATED HEARING LOSS IN C57BL/6 MICE. (2021): 235 - 243. 10.31086/tjgeri.2021.220 |
MLA | Muderris Togay,Sevil Ergun,yar sağlam atiye seda,Babademez Mehmet Ali COENZYME Q10 EFFECTIVELY PREVENTS AGE-RELATED HEARING LOSS IN C57BL/6 MICE. , 2021, ss.235 - 243. 10.31086/tjgeri.2021.220 |
AMA | Muderris T,Sevil E,yar sağlam a,Babademez M COENZYME Q10 EFFECTIVELY PREVENTS AGE-RELATED HEARING LOSS IN C57BL/6 MICE. . 2021; 235 - 243. 10.31086/tjgeri.2021.220 |
Vancouver | Muderris T,Sevil E,yar sağlam a,Babademez M COENZYME Q10 EFFECTIVELY PREVENTS AGE-RELATED HEARING LOSS IN C57BL/6 MICE. . 2021; 235 - 243. 10.31086/tjgeri.2021.220 |
IEEE | Muderris T,Sevil E,yar sağlam a,Babademez M "COENZYME Q10 EFFECTIVELY PREVENTS AGE-RELATED HEARING LOSS IN C57BL/6 MICE." , ss.235 - 243, 2021. 10.31086/tjgeri.2021.220 |
ISNAD | Muderris, Togay vd. "COENZYME Q10 EFFECTIVELY PREVENTS AGE-RELATED HEARING LOSS IN C57BL/6 MICE". (2021), 235-243. https://doi.org/10.31086/tjgeri.2021.220 |
APA | Muderris T, Sevil E, yar sağlam a, Babademez M (2021). COENZYME Q10 EFFECTIVELY PREVENTS AGE-RELATED HEARING LOSS IN C57BL/6 MICE. Türk Geriatri Dergisi, 24(2), 235 - 243. 10.31086/tjgeri.2021.220 |
Chicago | Muderris Togay,Sevil Ergun,yar sağlam atiye seda,Babademez Mehmet Ali COENZYME Q10 EFFECTIVELY PREVENTS AGE-RELATED HEARING LOSS IN C57BL/6 MICE. Türk Geriatri Dergisi 24, no.2 (2021): 235 - 243. 10.31086/tjgeri.2021.220 |
MLA | Muderris Togay,Sevil Ergun,yar sağlam atiye seda,Babademez Mehmet Ali COENZYME Q10 EFFECTIVELY PREVENTS AGE-RELATED HEARING LOSS IN C57BL/6 MICE. Türk Geriatri Dergisi, vol.24, no.2, 2021, ss.235 - 243. 10.31086/tjgeri.2021.220 |
AMA | Muderris T,Sevil E,yar sağlam a,Babademez M COENZYME Q10 EFFECTIVELY PREVENTS AGE-RELATED HEARING LOSS IN C57BL/6 MICE. Türk Geriatri Dergisi. 2021; 24(2): 235 - 243. 10.31086/tjgeri.2021.220 |
Vancouver | Muderris T,Sevil E,yar sağlam a,Babademez M COENZYME Q10 EFFECTIVELY PREVENTS AGE-RELATED HEARING LOSS IN C57BL/6 MICE. Türk Geriatri Dergisi. 2021; 24(2): 235 - 243. 10.31086/tjgeri.2021.220 |
IEEE | Muderris T,Sevil E,yar sağlam a,Babademez M "COENZYME Q10 EFFECTIVELY PREVENTS AGE-RELATED HEARING LOSS IN C57BL/6 MICE." Türk Geriatri Dergisi, 24, ss.235 - 243, 2021. 10.31086/tjgeri.2021.220 |
ISNAD | Muderris, Togay vd. "COENZYME Q10 EFFECTIVELY PREVENTS AGE-RELATED HEARING LOSS IN C57BL/6 MICE". Türk Geriatri Dergisi 24/2 (2021), 235-243. https://doi.org/10.31086/tjgeri.2021.220 |