TY  - JOUR
TI  - Dosimetric Comparison of Intensity-Modulated Radiation
Therapy and Volumetric Modulated Arc Therapy in
Craniospinal Radiotherapy of Childhood
AB  - OBJECTIVE
Central nervous system (CNS) tumors are the most common solid organ tumors in children. We aimed to
compare two modern radiotherapy techniques in target volumes and doses received by organs at risk (OAR).
METHODS
Eleven patients who had undergone 3D conformal radiotherapy (3DCRT) with the indication of craniospinal radiation therapy (CSRT) were included. OAR and target volumes were defined. The planned
target volume (PTV) was PTV of the brain and PTV of the entire spine. A total of 36 Gy at 1,8 Gy/fraction was given to all patients. Intensity-modulated radiation therapy (IMRT) and volumetric modulated
arc therapy (VMAT) plans were prepared.
RESULTS
At mean doses of optic nerve, thyroid, esophagus, heart and oral cavity; VMAT was significantly superior
to IMRT. At mean doses of lungs and kidneys; IMRT was better than VMAT. Dmax of VMAT was at lower
limits for all OAR. Regarding low doses received by the body, IMRT was better in V2 and V5; while VMAT
was better in V15 and V20. For PTV, V95 was 99% and 97%, and V107 was 2.6% and 4% in IMRT and
VMAT, respectively. Regarding monitor units (MU), VMAT revealed significantly lower MU than IMRT.
CONCLUSION
Two techniques are suitable treatment choices for CSRT and may be utilized to diminish the late adverse
effects of radiation and to increase disease-free survival rates in patients receiving CSRT. Nevertheless,
the risk of secondary cancer development should be kept in mind
AU  - Uzel, Ömer
AU  - Karacam, Songul
AU  - Çoban, Yasin
AU  - çifter, fulya
AU  - Ozer, elif eda
DO  - 10.5505/tjo.2020.2381
PY  - 2021
JO  - Türk Onkoloji Dergisi
VL  - 36
IS  - 1
SN  - 1300-7467
SP  - 96
EP  - 103
DB  - TRDizin
UR  - http://search/yayin/detay/510025
ER  -