Multipl Sklerozlu Hastalarda Güncel Diyet Yaklaşımları
Yıl: 2021 Cilt: 49 Sayı: 3 Sayfa Aralığı: 75 - 83 Metin Dili: Türkçe DOI: 10.33076/2021.BDD.1499 İndeks Tarihi: 27-05-2022
Multipl Sklerozlu Hastalarda Güncel Diyet Yaklaşımları
Öz: Multipl Skleroz (MS); nöroinflamatuvar, demiyelinize, otoimmün merkezi sinir sistemi hastalığıdır. MS ile ilişkili hastalık
süreci; inflamasyon, sinir liflerini koruyan ve çevreleyen membran yağ bileşeni, miyelin yıkımı ve/veya hasarı ile
sonuçlanmaktadır. Beslenme alışkanlıklarının ve yaşam tarzının MS seyrini etkileyip etkilemediği sorusu hala tartışma
konusudur. Diyet faktörleri ve bireyin yaşam tarzı alışkanlıkları, hem atak ve iyileşmelerle giden MS (Relapsing-remitting)
hem de birincil ilerleyici MS’de (primer progresif) hastalığın inflamatuvar durumunu modüle ederek semptomları
iyileştirebilir veya şiddetlendirebilir. Bu durum hücresel düzeyde hem metabolik hem de inflamatuvar yolları ve
kommensal bağırsak mikrobiyatasının bileşimini kontrol ederek oluşmaktadır. Sebzeler, meyveler, kurubaklagiller, balık,
prebiyotikler ve probiyotiklerden zengin düşük enerjili diyetlerin ve düzenli yapılan egzersizin; nükleer reseptörler ve
enzimler üzerinde olumlu etki oluşturduğu, oksidatif metabolizmayı ve proinflamatuvar molekülleri düzenlediği ve sağlıklı
simbiyotik bağırsak mikrobiyatasının sürdürülmesi ve restore edilmesine katkı sağladığı gösterilmiştir. Özellikle Akdeniz
tipi beslenme modeli gibi diyet müdahalelerinin; bağışıklık düzenleyici ilaçların olası yan etkilerini ve kronik yorgunluk
sendromunun semptomlarını hafifletmede, semptomların nüksetmesini ve hastalığın ilerlemesini önlemede yarar sağladığı
bildirilmektedir. MS hastalarının diyetlerindeki sağlıklı beslenmeye yönelik değişiklikler hastaların hem yaşam kalitesini
artırmakta hem de fiziksel ve mental iyileşme sağlamaktadır. Bu derlemede, farklı diyet modellerinin MS üzerindeki
etkisinin değerlendirilmesi amaçlanmıştır.
Anahtar Kelime: Current Dietary Approaches in Patients with Multiple Sclerosis
Öz: Multiple Sclerosis (MS); is a neuroinflammatory, demyelinated autoimmune central nervous system disease. MS-related
disease process result in inflammation, membrane fat component which protects and surrounds nerve fibers, myelin
destruction and/or damage. The question of whether nutrition habits and lifestyle affect the course of MS is still a matter
of debate. Dietary factors and lifestyle can improve or aggravate MS symptoms by modulating the inflammatory state of
the disease in both relapsing-remitting or primary progressive MS. This state occurs by controlling both metabolic and
inflammatory pathways in human cell and the composition of commensal gut microbiata. It has been shown that lowcalorie
diets rich in vegetables, fruits, legumes, fish, prebiotics and probiotics and routine exercise have a positive effect
on nuclear receptors and enzymes, regulate oxidative metabolism and proinflammatory molecules and contribute to the
maintenance and restoration of healthy symbiotic intestinal microbiata. It has been reported that dietary interventions such
as the Mediterranean diet model are beneficial in alleviating the possible side effects of immunomodulatory drugs and the
symptoms of chronic fatigue syndrome, preventing recurrence of symptoms and progression of the disease. Changes in the diets of MS patients towards healthy nutrition both increase the quality of life and provide physical and mental recovery of
patients. This review aims to evaluate the effect of different diet models on Multiple Sclerosis
Anahtar Kelime: Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık
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| APA | KAMANLI B, BILICI S (2021). Multipl Sklerozlu Hastalarda Güncel Diyet Yaklaşımları. , 75 - 83. 10.33076/2021.BDD.1499 |
| Chicago | KAMANLI BETÜL,BILICI SANIYE Multipl Sklerozlu Hastalarda Güncel Diyet Yaklaşımları. (2021): 75 - 83. 10.33076/2021.BDD.1499 |
| MLA | KAMANLI BETÜL,BILICI SANIYE Multipl Sklerozlu Hastalarda Güncel Diyet Yaklaşımları. , 2021, ss.75 - 83. 10.33076/2021.BDD.1499 |
| AMA | KAMANLI B,BILICI S Multipl Sklerozlu Hastalarda Güncel Diyet Yaklaşımları. . 2021; 75 - 83. 10.33076/2021.BDD.1499 |
| Vancouver | KAMANLI B,BILICI S Multipl Sklerozlu Hastalarda Güncel Diyet Yaklaşımları. . 2021; 75 - 83. 10.33076/2021.BDD.1499 |
| IEEE | KAMANLI B,BILICI S "Multipl Sklerozlu Hastalarda Güncel Diyet Yaklaşımları." , ss.75 - 83, 2021. 10.33076/2021.BDD.1499 |
| ISNAD | KAMANLI, BETÜL - BILICI, SANIYE. "Multipl Sklerozlu Hastalarda Güncel Diyet Yaklaşımları". (2021), 75-83. https://doi.org/10.33076/2021.BDD.1499 |
| APA | KAMANLI B, BILICI S (2021). Multipl Sklerozlu Hastalarda Güncel Diyet Yaklaşımları. Beslenme ve Diyet Dergisi, 49(3), 75 - 83. 10.33076/2021.BDD.1499 |
| Chicago | KAMANLI BETÜL,BILICI SANIYE Multipl Sklerozlu Hastalarda Güncel Diyet Yaklaşımları. Beslenme ve Diyet Dergisi 49, no.3 (2021): 75 - 83. 10.33076/2021.BDD.1499 |
| MLA | KAMANLI BETÜL,BILICI SANIYE Multipl Sklerozlu Hastalarda Güncel Diyet Yaklaşımları. Beslenme ve Diyet Dergisi, vol.49, no.3, 2021, ss.75 - 83. 10.33076/2021.BDD.1499 |
| AMA | KAMANLI B,BILICI S Multipl Sklerozlu Hastalarda Güncel Diyet Yaklaşımları. Beslenme ve Diyet Dergisi. 2021; 49(3): 75 - 83. 10.33076/2021.BDD.1499 |
| Vancouver | KAMANLI B,BILICI S Multipl Sklerozlu Hastalarda Güncel Diyet Yaklaşımları. Beslenme ve Diyet Dergisi. 2021; 49(3): 75 - 83. 10.33076/2021.BDD.1499 |
| IEEE | KAMANLI B,BILICI S "Multipl Sklerozlu Hastalarda Güncel Diyet Yaklaşımları." Beslenme ve Diyet Dergisi, 49, ss.75 - 83, 2021. 10.33076/2021.BDD.1499 |
| ISNAD | KAMANLI, BETÜL - BILICI, SANIYE. "Multipl Sklerozlu Hastalarda Güncel Diyet Yaklaşımları". Beslenme ve Diyet Dergisi 49/3 (2021), 75-83. https://doi.org/10.33076/2021.BDD.1499 |
