Familial Mediterranean Fever Mutation Analysis in
Pediatric Patients With İnflammatory Bowel Disease:
A Multicenter Study

Background: The aim of the study was to evaluate familial Mediterranean fever (FMF) mutation analysis in pediatric patients with inflammatory bowel disease (IBD). The relation between MEFV mutations and chronic inflammatory diseases has been reported previously. Methods: Children with IBD (334 ulcerative colitis (UC), 224 Crohn’s disease (CD), 39 indeterminate colitis (IC)) were tested for FMF mutations in this multicenter study. The distribution of mutations according to disease type, histopathological findings, and disease activity indexes was determined. Results: A total of 597 children (mean age: 10.8 ± 4.6 years, M/F: 1.05) with IBD were included in the study. In this study, 41.9% of the patients had FMF mutations. E148Q was the most common mutation in UC and CD, and M694V in IC (30.5%, 34.5%, 47.1%, respectively). There was a significant difference in terms of endoscopic and histopathological findings according to mutation types (homozygous/heterozygous) in patients with UC (P < .05). There was a statistically significant difference between colonoscopy findings in patients with or without mutations (P=.031, P=.045, respectively). The patients with UC who had mutations had lower Pediatric Ulcerative Colitis Activity Index (PUCAI) scores than the patients without mutations (P=.007). Conclusion: Although FMF mutations are unrelated to CD patients, but observed in UC patients with low PUCAI scores, it was established that mutations do not have a high impact on inflammatory response and clinical outcome of the disease.

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Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	URGANCI N, OZGENC F, Kuloglu Z, YÜKSEKKAYA H, SARI S, Erkan T, ÖNAL Z, Çaltepe G, AKÇAM M, ARSLAN D, arslan n, ARTAN R, AYDOĞAN A, Balamtekin N, Baran M, Baysoy G, CAKIR M, DALGIÇ B, DOĞAN Y, DURMAZ Ö, ECEVIT Ç, EREN M, Gökçe S, GÜLERMAN F, Gürakan F, HIZLI S, IŞIK I, Kalaycı A, KANSU A, Kutlu T, KARABİBER H, Kasırga E, Kutluk G, HOŞNUT F, ÖZEN H, ÖZKAN T, ÖZTÜRK Y, Bekem Soylu O, Tutar E, tumgor g, ÜNAL F, UGRAŞ M, ÜSTÜNDAĞ G, Yaman A, GROUP T (2021). Familial Mediterranean Fever Mutation Analysis in Pediatric Patients With İnflammatory Bowel Disease: A Multicenter Study. , 248 - 260. 10.5152/tjg.2021.20057
Chicago	URGANCI Nafiye,OZGENC Funda,Kuloglu Zarife,YÜKSEKKAYA Hasan,SARI Sinan,Erkan Tulay,ÖNAL Zerrin,Çaltepe Gönül,AKÇAM Mustafa,ARSLAN Duran,arslan nur,ARTAN REHA,AYDOĞAN Ayşen,Balamtekin Necati,Baran Masallah,Baysoy Gokhan,CAKIR Murat,DALGIÇ Buket,DOĞAN Yaşar,DURMAZ Özlem,ECEVIT Çiğdem,EREN Makbule,Gökçe Selim,GÜLERMAN Fulya,Gürakan Figen,HIZLI Samil,IŞIK Ishak,Kalaycı Ayhan Gazi,KANSU Aydan,Kutlu Tufan,KARABİBER Hamza,Kasırga Erhun,Kutluk Günsel,HOŞNUT Ferdağ ÖZBAY,ÖZEN Hasan,ÖZKAN Tanju,ÖZTÜRK Yeşim,Bekem Soylu Ozlem,Tutar Engin,tumgor gokhan,ÜNAL Fatih,UGRAŞ Meltem,ÜSTÜNDAĞ Gonca,Yaman Aytaç,GROUP Turkish IBD Study Familial Mediterranean Fever Mutation Analysis in Pediatric Patients With İnflammatory Bowel Disease: A Multicenter Study. (2021): 248 - 260. 10.5152/tjg.2021.20057
MLA	URGANCI Nafiye,OZGENC Funda,Kuloglu Zarife,YÜKSEKKAYA Hasan,SARI Sinan,Erkan Tulay,ÖNAL Zerrin,Çaltepe Gönül,AKÇAM Mustafa,ARSLAN Duran,arslan nur,ARTAN REHA,AYDOĞAN Ayşen,Balamtekin Necati,Baran Masallah,Baysoy Gokhan,CAKIR Murat,DALGIÇ Buket,DOĞAN Yaşar,DURMAZ Özlem,ECEVIT Çiğdem,EREN Makbule,Gökçe Selim,GÜLERMAN Fulya,Gürakan Figen,HIZLI Samil,IŞIK Ishak,Kalaycı Ayhan Gazi,KANSU Aydan,Kutlu Tufan,KARABİBER Hamza,Kasırga Erhun,Kutluk Günsel,HOŞNUT Ferdağ ÖZBAY,ÖZEN Hasan,ÖZKAN Tanju,ÖZTÜRK Yeşim,Bekem Soylu Ozlem,Tutar Engin,tumgor gokhan,ÜNAL Fatih,UGRAŞ Meltem,ÜSTÜNDAĞ Gonca,Yaman Aytaç,GROUP Turkish IBD Study Familial Mediterranean Fever Mutation Analysis in Pediatric Patients With İnflammatory Bowel Disease: A Multicenter Study. , 2021, ss.248 - 260. 10.5152/tjg.2021.20057
AMA	URGANCI N,OZGENC F,Kuloglu Z,YÜKSEKKAYA H,SARI S,Erkan T,ÖNAL Z,Çaltepe G,AKÇAM M,ARSLAN D,arslan n,ARTAN R,AYDOĞAN A,Balamtekin N,Baran M,Baysoy G,CAKIR M,DALGIÇ B,DOĞAN Y,DURMAZ Ö,ECEVIT Ç,EREN M,Gökçe S,GÜLERMAN F,Gürakan F,HIZLI S,IŞIK I,Kalaycı A,KANSU A,Kutlu T,KARABİBER H,Kasırga E,Kutluk G,HOŞNUT F,ÖZEN H,ÖZKAN T,ÖZTÜRK Y,Bekem Soylu O,Tutar E,tumgor g,ÜNAL F,UGRAŞ M,ÜSTÜNDAĞ G,Yaman A,GROUP T Familial Mediterranean Fever Mutation Analysis in Pediatric Patients With İnflammatory Bowel Disease: A Multicenter Study. . 2021; 248 - 260. 10.5152/tjg.2021.20057
Vancouver	URGANCI N,OZGENC F,Kuloglu Z,YÜKSEKKAYA H,SARI S,Erkan T,ÖNAL Z,Çaltepe G,AKÇAM M,ARSLAN D,arslan n,ARTAN R,AYDOĞAN A,Balamtekin N,Baran M,Baysoy G,CAKIR M,DALGIÇ B,DOĞAN Y,DURMAZ Ö,ECEVIT Ç,EREN M,Gökçe S,GÜLERMAN F,Gürakan F,HIZLI S,IŞIK I,Kalaycı A,KANSU A,Kutlu T,KARABİBER H,Kasırga E,Kutluk G,HOŞNUT F,ÖZEN H,ÖZKAN T,ÖZTÜRK Y,Bekem Soylu O,Tutar E,tumgor g,ÜNAL F,UGRAŞ M,ÜSTÜNDAĞ G,Yaman A,GROUP T Familial Mediterranean Fever Mutation Analysis in Pediatric Patients With İnflammatory Bowel Disease: A Multicenter Study. . 2021; 248 - 260. 10.5152/tjg.2021.20057
IEEE	URGANCI N,OZGENC F,Kuloglu Z,YÜKSEKKAYA H,SARI S,Erkan T,ÖNAL Z,Çaltepe G,AKÇAM M,ARSLAN D,arslan n,ARTAN R,AYDOĞAN A,Balamtekin N,Baran M,Baysoy G,CAKIR M,DALGIÇ B,DOĞAN Y,DURMAZ Ö,ECEVIT Ç,EREN M,Gökçe S,GÜLERMAN F,Gürakan F,HIZLI S,IŞIK I,Kalaycı A,KANSU A,Kutlu T,KARABİBER H,Kasırga E,Kutluk G,HOŞNUT F,ÖZEN H,ÖZKAN T,ÖZTÜRK Y,Bekem Soylu O,Tutar E,tumgor g,ÜNAL F,UGRAŞ M,ÜSTÜNDAĞ G,Yaman A,GROUP T "Familial Mediterranean Fever Mutation Analysis in Pediatric Patients With İnflammatory Bowel Disease: A Multicenter Study." , ss.248 - 260, 2021. 10.5152/tjg.2021.20057
ISNAD	URGANCI, Nafiye vd. "Familial Mediterranean Fever Mutation Analysis in Pediatric Patients With İnflammatory Bowel Disease: A Multicenter Study". (2021), 248-260. https://doi.org/10.5152/tjg.2021.20057

APA	URGANCI N, OZGENC F, Kuloglu Z, YÜKSEKKAYA H, SARI S, Erkan T, ÖNAL Z, Çaltepe G, AKÇAM M, ARSLAN D, arslan n, ARTAN R, AYDOĞAN A, Balamtekin N, Baran M, Baysoy G, CAKIR M, DALGIÇ B, DOĞAN Y, DURMAZ Ö, ECEVIT Ç, EREN M, Gökçe S, GÜLERMAN F, Gürakan F, HIZLI S, IŞIK I, Kalaycı A, KANSU A, Kutlu T, KARABİBER H, Kasırga E, Kutluk G, HOŞNUT F, ÖZEN H, ÖZKAN T, ÖZTÜRK Y, Bekem Soylu O, Tutar E, tumgor g, ÜNAL F, UGRAŞ M, ÜSTÜNDAĞ G, Yaman A, GROUP T (2021). Familial Mediterranean Fever Mutation Analysis in Pediatric Patients With İnflammatory Bowel Disease: A Multicenter Study. Turkish Journal of Gastroenterology, 32(3), 248 - 260. 10.5152/tjg.2021.20057
Chicago	URGANCI Nafiye,OZGENC Funda,Kuloglu Zarife,YÜKSEKKAYA Hasan,SARI Sinan,Erkan Tulay,ÖNAL Zerrin,Çaltepe Gönül,AKÇAM Mustafa,ARSLAN Duran,arslan nur,ARTAN REHA,AYDOĞAN Ayşen,Balamtekin Necati,Baran Masallah,Baysoy Gokhan,CAKIR Murat,DALGIÇ Buket,DOĞAN Yaşar,DURMAZ Özlem,ECEVIT Çiğdem,EREN Makbule,Gökçe Selim,GÜLERMAN Fulya,Gürakan Figen,HIZLI Samil,IŞIK Ishak,Kalaycı Ayhan Gazi,KANSU Aydan,Kutlu Tufan,KARABİBER Hamza,Kasırga Erhun,Kutluk Günsel,HOŞNUT Ferdağ ÖZBAY,ÖZEN Hasan,ÖZKAN Tanju,ÖZTÜRK Yeşim,Bekem Soylu Ozlem,Tutar Engin,tumgor gokhan,ÜNAL Fatih,UGRAŞ Meltem,ÜSTÜNDAĞ Gonca,Yaman Aytaç,GROUP Turkish IBD Study Familial Mediterranean Fever Mutation Analysis in Pediatric Patients With İnflammatory Bowel Disease: A Multicenter Study. Turkish Journal of Gastroenterology 32, no.3 (2021): 248 - 260. 10.5152/tjg.2021.20057
MLA	URGANCI Nafiye,OZGENC Funda,Kuloglu Zarife,YÜKSEKKAYA Hasan,SARI Sinan,Erkan Tulay,ÖNAL Zerrin,Çaltepe Gönül,AKÇAM Mustafa,ARSLAN Duran,arslan nur,ARTAN REHA,AYDOĞAN Ayşen,Balamtekin Necati,Baran Masallah,Baysoy Gokhan,CAKIR Murat,DALGIÇ Buket,DOĞAN Yaşar,DURMAZ Özlem,ECEVIT Çiğdem,EREN Makbule,Gökçe Selim,GÜLERMAN Fulya,Gürakan Figen,HIZLI Samil,IŞIK Ishak,Kalaycı Ayhan Gazi,KANSU Aydan,Kutlu Tufan,KARABİBER Hamza,Kasırga Erhun,Kutluk Günsel,HOŞNUT Ferdağ ÖZBAY,ÖZEN Hasan,ÖZKAN Tanju,ÖZTÜRK Yeşim,Bekem Soylu Ozlem,Tutar Engin,tumgor gokhan,ÜNAL Fatih,UGRAŞ Meltem,ÜSTÜNDAĞ Gonca,Yaman Aytaç,GROUP Turkish IBD Study Familial Mediterranean Fever Mutation Analysis in Pediatric Patients With İnflammatory Bowel Disease: A Multicenter Study. Turkish Journal of Gastroenterology, vol.32, no.3, 2021, ss.248 - 260. 10.5152/tjg.2021.20057
AMA	URGANCI N,OZGENC F,Kuloglu Z,YÜKSEKKAYA H,SARI S,Erkan T,ÖNAL Z,Çaltepe G,AKÇAM M,ARSLAN D,arslan n,ARTAN R,AYDOĞAN A,Balamtekin N,Baran M,Baysoy G,CAKIR M,DALGIÇ B,DOĞAN Y,DURMAZ Ö,ECEVIT Ç,EREN M,Gökçe S,GÜLERMAN F,Gürakan F,HIZLI S,IŞIK I,Kalaycı A,KANSU A,Kutlu T,KARABİBER H,Kasırga E,Kutluk G,HOŞNUT F,ÖZEN H,ÖZKAN T,ÖZTÜRK Y,Bekem Soylu O,Tutar E,tumgor g,ÜNAL F,UGRAŞ M,ÜSTÜNDAĞ G,Yaman A,GROUP T Familial Mediterranean Fever Mutation Analysis in Pediatric Patients With İnflammatory Bowel Disease: A Multicenter Study. Turkish Journal of Gastroenterology. 2021; 32(3): 248 - 260. 10.5152/tjg.2021.20057
Vancouver	URGANCI N,OZGENC F,Kuloglu Z,YÜKSEKKAYA H,SARI S,Erkan T,ÖNAL Z,Çaltepe G,AKÇAM M,ARSLAN D,arslan n,ARTAN R,AYDOĞAN A,Balamtekin N,Baran M,Baysoy G,CAKIR M,DALGIÇ B,DOĞAN Y,DURMAZ Ö,ECEVIT Ç,EREN M,Gökçe S,GÜLERMAN F,Gürakan F,HIZLI S,IŞIK I,Kalaycı A,KANSU A,Kutlu T,KARABİBER H,Kasırga E,Kutluk G,HOŞNUT F,ÖZEN H,ÖZKAN T,ÖZTÜRK Y,Bekem Soylu O,Tutar E,tumgor g,ÜNAL F,UGRAŞ M,ÜSTÜNDAĞ G,Yaman A,GROUP T Familial Mediterranean Fever Mutation Analysis in Pediatric Patients With İnflammatory Bowel Disease: A Multicenter Study. Turkish Journal of Gastroenterology. 2021; 32(3): 248 - 260. 10.5152/tjg.2021.20057
IEEE	URGANCI N,OZGENC F,Kuloglu Z,YÜKSEKKAYA H,SARI S,Erkan T,ÖNAL Z,Çaltepe G,AKÇAM M,ARSLAN D,arslan n,ARTAN R,AYDOĞAN A,Balamtekin N,Baran M,Baysoy G,CAKIR M,DALGIÇ B,DOĞAN Y,DURMAZ Ö,ECEVIT Ç,EREN M,Gökçe S,GÜLERMAN F,Gürakan F,HIZLI S,IŞIK I,Kalaycı A,KANSU A,Kutlu T,KARABİBER H,Kasırga E,Kutluk G,HOŞNUT F,ÖZEN H,ÖZKAN T,ÖZTÜRK Y,Bekem Soylu O,Tutar E,tumgor g,ÜNAL F,UGRAŞ M,ÜSTÜNDAĞ G,Yaman A,GROUP T "Familial Mediterranean Fever Mutation Analysis in Pediatric Patients With İnflammatory Bowel Disease: A Multicenter Study." Turkish Journal of Gastroenterology, 32, ss.248 - 260, 2021. 10.5152/tjg.2021.20057
ISNAD	URGANCI, Nafiye vd. "Familial Mediterranean Fever Mutation Analysis in Pediatric Patients With İnflammatory Bowel Disease: A Multicenter Study". Turkish Journal of Gastroenterology 32/3 (2021), 248-260. https://doi.org/10.5152/tjg.2021.20057