TY  - JOUR
TI  - Familial Mediterranean Fever Mutation Analysis in
Pediatric Patients With İnflammatory Bowel Disease:
A Multicenter Study
AB  - Background: The aim of the study was to evaluate familial Mediterranean fever (FMF) mutation analysis in pediatric patients with inflammatory bowel disease (IBD). The relation between MEFV mutations and chronic inflammatory diseases has been reported previously.
Methods: Children with IBD (334 ulcerative colitis (UC), 224 Crohn’s disease (CD), 39 indeterminate colitis (IC)) were tested for FMF
mutations in this multicenter study. The distribution of mutations according to disease type, histopathological findings, and disease
activity indexes was determined.
Results: A total of 597 children (mean age: 10.8 ± 4.6 years, M/F: 1.05) with IBD were included in the study. In this study, 41.9% of the
patients had FMF mutations. E148Q was the most common mutation in UC and CD, and M694V in IC (30.5%, 34.5%, 47.1%, respectively). There was a significant difference in terms of endoscopic and histopathological findings according to mutation types (homozygous/heterozygous) in patients with UC (P < .05).
There was a statistically significant difference between colonoscopy findings in patients with or without mutations (P=.031, P=.045,
respectively). The patients with UC who had mutations had lower Pediatric Ulcerative Colitis Activity Index (PUCAI) scores than the
patients without mutations (P=.007).
Conclusion: Although FMF mutations are unrelated to CD patients, but observed in UC patients with low PUCAI scores, it was established that mutations do not have a high impact on inflammatory response and clinical outcome of the disease.
AU  - Gürakan, Figen
AU  - Kasırga, Erhun
AU  - tumgor, gokhan
AU  - OZGENC, Funda
AU  - Gökçe, Selim
AU  - GÜLERMAN, Fulya
AU  - HOŞNUT, Ferdağ ÖZBAY
AU  - Çaltepe, Gönül
AU  - GROUP, Turkish IBD Study
AU  - Balamtekin, Necati
AU  - DALGIÇ, Buket
AU  - ÖZKAN, Tanju
AU  - ÖZTÜRK, Yeşim
AU  - HIZLI, Samil
AU  - DURMAZ, Özlem
AU  - ÖZEN, Hasan
AU  - Baysoy, Gokhan
AU  - Erkan, Tulay
AU  - KANSU, Aydan
AU  - CAKIR, Murat
AU  - ÜNAL, Fatih
AU  - AYDOĞAN, Ayşen
AU  - Kutluk, Günsel
AU  - Tutar, Engin
AU  - ÖNAL, Zerrin
AU  - ARSLAN, Duran
AU  - SARI, Sinan
AU  - AKÇAM, Mustafa
AU  - Baran, Masallah
AU  - Kutlu, Tufan
AU  - ECEVIT, Çiğdem
AU  - arslan, nur
AU  - ARTAN, REHA
AU  - Kuloglu, Zarife
AU  - YÜKSEKKAYA, Hasan
AU  - EREN, Makbule
AU  - Bekem Soylu, Ozlem
AU  - KARABİBER, Hamza
AU  - IŞIK, Ishak
AU  - URGANCI, Nafiye
AU  - ÜSTÜNDAĞ, Gonca
AU  - Yaman, Aytaç
AU  - DOĞAN, Yaşar
AU  - Kalaycı, Ayhan  Gazi
AU  - UGRAŞ, Meltem
DO  - 10.5152/tjg.2021.20057
PY  - 2021
JO  - Turkish Journal of Gastroenterology
VL  - 32
IS  - 3
SN  - 1300-4948
SP  - 248
EP  - 260
DB  - TRDizin
UR  - http://search/yayin/detay/510127
ER  -