TY  - JOUR
TI  - Etiological causes and prognosis in children with
neutropenia
AB  - OBJECTIVE: Neutropenia is defined as an absolute neutrophil count (ANC) below 1500/mm3 in the peripheral blood and is
a common condition in childhood. In this study, underlying etiological causes and prognoses in children in follow-up due to
neutropenia were analyzed to form a guide for physicians working in primary health care institutions.
METHODS: The medical records of pediatric patients who were followed up as an inpatients or outpatients due to neutropenia
between October 2014 and October 2017 were reviewed retrospectively.
RESULTS: A total of 94 patients were included in the study with a median age of 24 (8–77) months. The median ANC at the
time of admission was 600 (300–970)/mm3. The ANC was 0–500/mm3 in 34 patients (36.2%), 500–1000/mm3 in 36 patients
(38.3%), and 1000–1500/mm3 in 24 patients (25.5%). Of the total, 43 patients (45.7%) were followed up as inpatients and 51
(54.3%) were followed as outpatients. Fifty-five patients (58.5%) were diagnosed with post-infectious neutropenia. The most
common focus of infection was the upper respiratory airway (38.4%). The etiological cause could not be identified in 23 (24.6%)
patients, neutropenia developed during drug use in 6 patients (6.3%), 5 patients (5.3%) were diagnosed with Vitamin B12
deficiency (Vitamin B12 level: 168 [129–174] pg/ml, the levels were studied in 48 patients), 2 patients (2%) were diagnosed
with chronic benign neutropenia, 1 patient (1.1%) was diagnosed with immune deficiency, 1 patient (1.1%) was diagnosed with
autoimmune lymphoproliferative syndrome, and 1 patient (1.1%) was diagnosed with hemophagocytic lymphohistiocytosis secondary
to a previous infection. No patient was diagnosed with congenital neutropenia. A total of 91 patients (96.8%) recovered
from the neutropenia. Neutropenia did not improve in 3 patients (3.2%). One patient was lost due to infection.
CONCLUSION: Etiological cause can be shown in approximately 75% of neutropenic children. The most common etiological
cause is infection. Drug use, nutritional deficiencies, and chronic benign neutropenia are less common causes of neutropenia.
The clinical course is largely benign and the mortality rate is very low.
AU  - Kasacı, Bilge
AU  - düzenli kar, yeter
AU  - Özdemir, Zeynep Canan
AU  - Bör, Özcan
DO  - 10.14744/nci.2020.65624
PY  - 2021
JO  - İstanbul Kuzey Klinikleri
VL  - 8
IS  - 3
SN  - 2148-4902
SP  - 236
EP  - 242
DB  - TRDizin
UR  - http://search/yayin/detay/510167
ER  -