TY  - JOUR
TI  - Assessment of respiratory tract viruses in febrile
neutropenic etiology in children and comparison
with healthy children with upper/lower respiratory
tract infection
AB  - OBJECTIVE: This study aims to compare the frequency of respiratory viruses using real-time and multiplex polymerase chain
reaction technology and nasopharyngeal swabs taken during exacerbation of patients aged 0–18 years followed for febrile
neutropenia (FN) with non-FN children.
METHODS: This prospective study included a total of 40 patients with FN and malignancies followed at Eskisehir Osmangazi
University, Department of Pediatric Hematology and Oncology. The control group (n=76) consisted of age-matched patients
with upper respiratory tract infections (URTIs) or lower respiratory tract infections (LRTIs) who were admitted to the emergency
service due to fever.
RESULTS: Viral agents were detected in 16 of 53 FN attacks (30.1%). The most commonly isolated viruses were coronavirus
(23.7%, n=9), influenza B (18.4%, n=7), and adenovirus (18.4%, n=7). Of 76 children diagnosed with URTI with fever
(52.6%) had viral agents, and only 28 of them had a single agent. The most commonly isolated virus was adenovirus (28.6%,
n=14). Viral factors were found in 32 of 42 patients (76.1%) patients diagnosed with LRTI, while respiratory syncytial virus
was the most common virus in 27 patients (21.7%, n=5).
CONCLUSION: Our study results show that viral agents play an important role in the etiology of FN. This is the first study
to show that viral agents play an important role in the etiology of this disease and viral factors in non-neutropenic febrile
children at the same time period by detecting respiratory viruses in 30% of FN cases. More similar studies provide antiviral
therapy in selected patients, as well as these studies lead to reduce the use of antimicrobial agents or allow more selective
use of antibiotics and/or the earlier discontinuation of these antibiotics in febrile neutropenic children who have been shown
to have viral cause of respiratory tract infection based on clinical and microbiological/molecular diagnostic criteria.
AU  - Us, Tercan
AU  - Kasifoglu, Nilgun
AU  - YİLDİRİM, Gonca Kilic
AU  - Bozkurt Turhan, Ayşe
AU  - Özdemir, Zeynep Canan
AU  - Bör, Özcan
AU  - Dinleyici, Ener Cagri
DO  - 10.14744/nci.2020.99896
PY  - 2021
JO  - İstanbul Kuzey Klinikleri
VL  - 8
IS  - 3
SN  - 2148-4902
SP  - 249
EP  - 254
DB  - TRDizin
UR  - http://search/yayin/detay/510173
ER  -