TY  - JOUR
TI  - The concordance between colposcopic biopsy
and loop electrosurgical excision procedures in
patients with known smear cytology and human
papillomavirus results
AB  - OBJECTIVE: The objective of the study was to evaluate the concordance between colposcopic biopsy and loop electrosurgical excision procedure (LEEP) methods to diagnose cervical pre-invasive lesions and cervical cancer, and to calculate the low
and high prediction rates of lesions for both methods.
METHODS: A total of 241 patients who underwent LEEP after colposcopic biopsy for different indications and also known
cervical cytology and human papillomavirus test results were included in the study. Clinical variables such as age, gravida,
parity, menopausal status, smoking, endocervical curettage results, and surgical margins were recorded.
RESULTS: The total concordance between colposcopic biopsy and LEEP was 41.9%. The rates of finding a more serious
lesion than in colposcopic biopsy with LEEP (underestimation) for negative, Cervical Intraepithelial Neoplasia (CIN) 1, CIN
2, and CIN 3 were calculated as 100%, 12.8%, 14.8%, and 3.9%, respectively. Rates of finding a less serious lesion than
detected in colposcopic biopsy with LEEP (overestimation) for CIN 1, CIN 2, and CIN 3, cervical carcinoma were calculated
as 56.4%, 33.3%, 3.9%, and 0%, respectively. Underestimation was seen in a total of 28 patients, and overestimation was
present in 113 patients. Parity was found to be the only associated factor that affected the final diagnosis for high-grade
lesions in univariate logistic regression analysis (odds ratio=1.234, 95% confidence interval: 1.005–1.514).
CONCLUSION: Discrepancies between colposcopically directed punch biopsy and subsequent histopathologic LEEP findings
are common. New methods to reduce the inconsistency between colposcopic biopsy and LEEP are necessary to prevent patients from being under or over treated.
AU  - Kanbay ozturk, Sumeyye
AU  - Yücesoy, İzzet
AU  - balcı, sibel
AU  - gezer, şener
DO  - 10.14744/nci.2021.80090
PY  - 2021
JO  - İstanbul Kuzey Klinikleri
VL  - 8
IS  - 6
SN  - 2148-4902
SP  - 588
EP  - 594
DB  - TRDizin
UR  - http://search/yayin/detay/510459
ER  -