Resveratrol against lung injury in an ischemia/reperfusion model of abdominal aortic rupture
Yıl: 2021 Cilt: 29 Sayı: 3 Sayfa Aralığı: 330 - 338 Metin Dili: İngilizce DOI: 10.5606/tgkdc.dergisi.2021.21737 İndeks Tarihi: 28-05-2022
Resveratrol against lung injury in an ischemia/reperfusion model of abdominal aortic rupture
Öz: Background: The aim of this study was to examine the effects on the
lungs of ischemia/reperfusion injury in a ruptured abdominal aortic
aneurysm model in rats and to investigate the potential protective effects
of resveratrol.
Methods: Thirty-two male Sprague-Dawley rats were randomly divided
into four groups: control, ischemia/reperfusion, sham (ischemia/
reperfusion + solvent/dimethyl sulfoxide), and ischemia/reperfusion +
resveratrol. In the groups subjected to ischemia/reperfusion, following
60-min shock to the abdominal aorta, vascular clamps were attached
from the levels of the infrarenal and iliac bifurcation. A total of 60-min
ischemia was applied, followed by 120-min reperfusion. In the ischemia/
reperfusion + resveratrol group, intraperitoneal 10 mg/kg resveratrol was
administered 15 min before ischemia and immediately after reperfusion.
Malondialdehyde, glutathione, and catalase levels were analyzed and
histopathological examination of the lung tissues was performed.
Results: Malondialdehyde levels increased in the ischemia/reperfusion
and ischemia/reperfusion + dimethyl sulfoxide groups, compared to
the control group, while catalase levels decreased, and no significant
difference was observed in the glutathione levels. Malondialdehyde
levels decreased with the administration of resveratrol, while glutathione
levels increased, and catalase levels remained unchanged. The increased
inflammation in interstitial spaces, thickening in the alveolar septal
walls, increased numbers of cleaved caspase-3 apoptotic pneumocytes,
and increased histopathological lung damage scores observed in the
ischemia/reperfusion and ischemia/reperfusion + dimethyl sulfoxide
groups improved with the application of resveratrol.
Conclusion: These findings suggest that resveratrol may exhibit a
protective effect in preventing acute lung injury developing due to
ischemia/reperfusion in ruptured abdominal aortic aneurysm surgery by
reducing oxidative damage.
Anahtar Kelime: Abdominal aort rüptürü iskemi/reperfüzyon modelinde akciğer hasarına karşı resveratrol
Öz: Amaç: Bu çalışmada sıçanlarda rüptüre abdominal aort anevrizması
modelinde iskemi/reperfüzyon hasarının akciğerlerdeki etkileri
incelendi ve resveratrolün olası koruyucu etkileri araştırıldı.
Çalışma planı: Otuz iki erkek Sprague-Dawley sıçanı rastgele
dört gruba ayrıldı: kontrol, iskemi/reperfüzyon, sham (iskemi/
reperfüzyon+solvent/dimetil sülfoksit) ve iskemi/reperfüzyon
+resveratrol. İskemi/reperfüzyon uygulanan gruplarda abdominal aorta
60 dk. şokun ardından infrarenal ve iliyak bifurkasyon seviyelerinden
vasküler klempler yerleştirildi. Toplamda 60 dk. iskemiyi takiben
120 dk. reperfüzyon uygulandı. İskemi/reperfüzyon + resveratrol
grubuna, iskemiden 15 dk. önce ve reperfüzyondan hemen önce
intraperitonal yoldan 10 mg/kg resveratrol uygulandı. Malondialdehit,
glutatyon ve katalaz düzeyleri araştırıldı ve akciğer dokusunda
histopatolojik değerlendirme yapıldı.
Bulgular: Kontrol grubuna kıyasla iskemi/reperfüzyon ve iskemi/
reperfüzyon + dimetil sülfoksit gruplarında, malondialdehit düzeyleri
arttı, katalaz düzeyleri azaldı ve glutatyon düzeylerinde anlamlı
bir fark gözlenmedi. Resveratrol uygulanması ile malondialdehit
düzeyleri azalırken, glutatyon düzeyleri arttı ve katalaz düzeyleri
değişmedi. Ayrıca, iskemi/reperfüzyon ve iskemi/reperfüzyon + dimetil
sülfoksit gruplarında gözlenen interstisyel alanlarda enflamasyon
artışı, damarlarda hiyalin membran yapılarının birikimi, alveolar
septal duvarında kalınlaşma ve cleaved caspase-3 pozitif apoptotik
pnömositlerin sayısındaki ve akciğer histopatolojik tahribat skorundaki
artış resveratrol uygulanması ile geriledi.
Sonuç: Bu bulgular, resveratrolün rüptüre abdominal aort anevrizması
cerrahisinde iskemi/reperfüzyon nedeniyle gelişen akut akciğer
hasarının önlenmesinde oksidatif tahribatı azaltarak koruyucu etkinliği
olabileceğini göstermektedir
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA | Karakişi O, Hemşinli D, Tumkaya L, mercantepe t, yılmaz a (2021). Resveratrol against lung injury in an ischemia/reperfusion model of abdominal aortic rupture. , 330 - 338. 10.5606/tgkdc.dergisi.2021.21737 |
Chicago | Karakişi Ozan,Hemşinli Doğuş,Tumkaya Levent,mercantepe tolga,yılmaz adnan Resveratrol against lung injury in an ischemia/reperfusion model of abdominal aortic rupture. (2021): 330 - 338. 10.5606/tgkdc.dergisi.2021.21737 |
MLA | Karakişi Ozan,Hemşinli Doğuş,Tumkaya Levent,mercantepe tolga,yılmaz adnan Resveratrol against lung injury in an ischemia/reperfusion model of abdominal aortic rupture. , 2021, ss.330 - 338. 10.5606/tgkdc.dergisi.2021.21737 |
AMA | Karakişi O,Hemşinli D,Tumkaya L,mercantepe t,yılmaz a Resveratrol against lung injury in an ischemia/reperfusion model of abdominal aortic rupture. . 2021; 330 - 338. 10.5606/tgkdc.dergisi.2021.21737 |
Vancouver | Karakişi O,Hemşinli D,Tumkaya L,mercantepe t,yılmaz a Resveratrol against lung injury in an ischemia/reperfusion model of abdominal aortic rupture. . 2021; 330 - 338. 10.5606/tgkdc.dergisi.2021.21737 |
IEEE | Karakişi O,Hemşinli D,Tumkaya L,mercantepe t,yılmaz a "Resveratrol against lung injury in an ischemia/reperfusion model of abdominal aortic rupture." , ss.330 - 338, 2021. 10.5606/tgkdc.dergisi.2021.21737 |
ISNAD | Karakişi, Ozan vd. "Resveratrol against lung injury in an ischemia/reperfusion model of abdominal aortic rupture". (2021), 330-338. https://doi.org/10.5606/tgkdc.dergisi.2021.21737 |
APA | Karakişi O, Hemşinli D, Tumkaya L, mercantepe t, yılmaz a (2021). Resveratrol against lung injury in an ischemia/reperfusion model of abdominal aortic rupture. Türk Göğüs Kalp Damar Cerrahisi Dergisi, 29(3), 330 - 338. 10.5606/tgkdc.dergisi.2021.21737 |
Chicago | Karakişi Ozan,Hemşinli Doğuş,Tumkaya Levent,mercantepe tolga,yılmaz adnan Resveratrol against lung injury in an ischemia/reperfusion model of abdominal aortic rupture. Türk Göğüs Kalp Damar Cerrahisi Dergisi 29, no.3 (2021): 330 - 338. 10.5606/tgkdc.dergisi.2021.21737 |
MLA | Karakişi Ozan,Hemşinli Doğuş,Tumkaya Levent,mercantepe tolga,yılmaz adnan Resveratrol against lung injury in an ischemia/reperfusion model of abdominal aortic rupture. Türk Göğüs Kalp Damar Cerrahisi Dergisi, vol.29, no.3, 2021, ss.330 - 338. 10.5606/tgkdc.dergisi.2021.21737 |
AMA | Karakişi O,Hemşinli D,Tumkaya L,mercantepe t,yılmaz a Resveratrol against lung injury in an ischemia/reperfusion model of abdominal aortic rupture. Türk Göğüs Kalp Damar Cerrahisi Dergisi. 2021; 29(3): 330 - 338. 10.5606/tgkdc.dergisi.2021.21737 |
Vancouver | Karakişi O,Hemşinli D,Tumkaya L,mercantepe t,yılmaz a Resveratrol against lung injury in an ischemia/reperfusion model of abdominal aortic rupture. Türk Göğüs Kalp Damar Cerrahisi Dergisi. 2021; 29(3): 330 - 338. 10.5606/tgkdc.dergisi.2021.21737 |
IEEE | Karakişi O,Hemşinli D,Tumkaya L,mercantepe t,yılmaz a "Resveratrol against lung injury in an ischemia/reperfusion model of abdominal aortic rupture." Türk Göğüs Kalp Damar Cerrahisi Dergisi, 29, ss.330 - 338, 2021. 10.5606/tgkdc.dergisi.2021.21737 |
ISNAD | Karakişi, Ozan vd. "Resveratrol against lung injury in an ischemia/reperfusion model of abdominal aortic rupture". Türk Göğüs Kalp Damar Cerrahisi Dergisi 29/3 (2021), 330-338. https://doi.org/10.5606/tgkdc.dergisi.2021.21737 |