TY  - JOUR
TI  - Resveratrol against lung injury in an ischemia/reperfusion model of
abdominal aortic rupture
AB  - Background: The aim of this study was to examine the effects on the
lungs of ischemia/reperfusion injury in a ruptured abdominal aortic
aneurysm model in rats and to investigate the potential protective effects
of resveratrol.
Methods: Thirty-two male Sprague-Dawley rats were randomly divided
into four groups: control, ischemia/reperfusion, sham (ischemia/
reperfusion + solvent/dimethyl sulfoxide), and ischemia/reperfusion +
resveratrol. In the groups subjected to ischemia/reperfusion, following
60-min shock to the abdominal aorta, vascular clamps were attached
from the levels of the infrarenal and iliac bifurcation. A total of 60-min
ischemia was applied, followed by 120-min reperfusion. In the ischemia/
reperfusion + resveratrol group, intraperitoneal 10 mg/kg resveratrol was
administered 15 min before ischemia and immediately after reperfusion.
Malondialdehyde, glutathione, and catalase levels were analyzed and
histopathological examination of the lung tissues was performed.
Results: Malondialdehyde levels increased in the ischemia/reperfusion
and ischemia/reperfusion + dimethyl sulfoxide groups, compared to
the control group, while catalase levels decreased, and no significant
difference was observed in the glutathione levels. Malondialdehyde
levels decreased with the administration of resveratrol, while glutathione
levels increased, and catalase levels remained unchanged. The increased
inflammation in interstitial spaces, thickening in the alveolar septal
walls, increased numbers of cleaved caspase-3 apoptotic pneumocytes,
and increased histopathological lung damage scores observed in the
ischemia/reperfusion and ischemia/reperfusion + dimethyl sulfoxide
groups improved with the application of resveratrol.
Conclusion: These findings suggest that resveratrol may exhibit a
protective effect in preventing acute lung injury developing due to
ischemia/reperfusion in ruptured abdominal aortic aneurysm surgery by
reducing oxidative damage.
AU  - Karakişi, Ozan
AU  - Hemşinli, Doğuş
AU  - Tumkaya, Levent
AU  - yılmaz, adnan
AU  - mercantepe, tolga
DO  - 10.5606/tgkdc.dergisi.2021.21737
PY  - 2021
JO  - Türk Göğüs Kalp Damar Cerrahisi Dergisi
VL  - 29
IS  - 3
SN  - 1301-5680
SP  - 330
EP  - 338
DB  - TRDizin
UR  - http://search/yayin/detay/510625
ER  -