TY  - JOUR
TI  - The role of telomerase in the etiology of primary spontaneous pneumothorax
AB  - Background: This study aims to investigate the role of telomerase
activity in the risk of primary spontaneous pneumothorax, which
is most frequently encountered in the practice of thoracic surgery.
Methods: A total of 61 patients (56 males, 5 females; median age:
29.4 years; range, 17 to 43 years) who underwent treatment for
primary spontaneous pneumothorax and 19 age- and sex-matched
healthy controls (10 males, 9 females; median age: 29.1 years; range,
23 to 43 years) were included in this prospective study between
January 2018 - August 2018. Telomerase activity was evaluated
with enzyme-linked immunosorbent assay. The correlation between
telomerase activity and clinical and demographic parameters was
examined.
Results: The mean serum telomerase level was 3.4±0.6 ng/mL in
the primary spontaneous pneumothorax group and 1.9±0.5 ng/mL in
the control group, indicating significantly higher levels in the patient
group (p<0.001). There was no significant association between the
telomerase levels and presence of blebs and/or bullae on thoracic
computed tomography, extent of pneumothorax, laterality (right, left,
or bilateral), and pack years of cigarette smoking.
Conclusion: Telomerase levels of patients with primary spontaneous
pneumothorax are significantly higher than healthy individuals.
Future genetic studies may ultimately clarify a potential relationship
between primary spontaneous pneumothorax and short telomere
syndrome.
AU  - gürler, fatih
AU  - Karakukcu, Cigdem
AU  - özsoy, ibrahim ethem
AU  - tezcan, mehmet akif
DO  - 10.5606/tgkdc.dergisi.2021.20522
PY  - 2021
JO  - Türk Göğüs Kalp Damar Cerrahisi Dergisi
VL  - 29
IS  - 3
SN  - 1301-5680
SP  - 377
EP  - 383
DB  - TRDizin
UR  - http://search/yayin/detay/510636
ER  -